Attention-Deficit/Hyperactivity Disorder (ADHD) and Reading Abilities: A Comprehensive Review

Attention-Deficit/Hyperactivity Disorder (ADHD), is a neurodevelopmental disorder that is characterized by “a consistent pattern of inattention and/or hyperactivity/impulsivity symptoms that interferes with functioning in at least two domains” (DSM-V, 2013). While most studies link reading impairments to attention symptoms, Kagan’s (1965) seminal work documents a significant positive correlation between cognitive impulsivity and reading abilities in typically developing school-aged children (Kagan 1965). Moreover, extant research documents a relation between academic achievement impairments and ADHD-related cognitive impairments (i.e., executive functions). The purpose of this review is to examine ADHD-related reading abilities. We aim to outline the foundation for research on the relation between reading abilities and ADHD symptoms. We will examine both reading abilities broadly and examine specific reading-related processes (i.e., reading comprehension and reading decoding). Moreover, we will examine the relation between impulsivity and reading abilities in school-aged children diagnosed with ADHD. Our goal is to understand the etiology (i.e., root cause) of impaired reading abilities in school-aged children diagnosed with ADHD. Clinical and research implications will be discussed

Angiotensin-converting enzyme gene polymorphisms and obesity: An examination of three black populations

We examined the association between obesity and 13 angiotensin-converting enzyme (ACE) gene polymorphisms, including the presence (I) or absence (D) of an Alu element in intron 16 (I/D polymorphism), and performed haplotype analysis using data collected from participants of a community survey of hypertension among blacks living in Ibadan, Nigeria; Spanish Town, Jamaica; and Chicago, IL. Transmission distortion of ACE gene polymorphisms and haplotypes from heterozygous parents to affected offspring was examined in each study population. To estimate haplotypes, polymorphisms were divided into three groups based on their position on the ACE gene. No ACE gene polymorphism was consistently overtransmitted from parents to obese offspring among the three populations. However, the haplotype ACE1-ACE5 TACAT, located in the promoter region, was significantly overtransmitted from parents to obese offspring in both the U.S. and Nigerian populations. No haplotype was significantly overtransmitted from parents to obese offspring among the Jamaicans. In conclusion, we noted the overtransmission of a particular ACE gene promoter region haplotype from parents to obese offspring in two separate black populations. These data suggest that ACE gene polymorphisms may influence the development of weight gain. Copyright © 2005 NAASO

Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians

Purpose: A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney disease clinically attributed to hypertension among African Americans. The purposes of the current study were, therefore, to examine the frequency of these variants and to determine whether they are associated with chronic kidney disease (CKD) among native Africans. Methods: To investigate the possible evidence of association between variants in these genes and non-diabetic CKD among West Africans, we performed a case/control analysis in a sample of 166 Nigerians without history of European admixture. Our study included a total of 9 variants on APOL1 (n = 4) and MYH9 (n = 5) genes. Results: We observed significantly strong associations with previously reported APOL1 variants rs73885319 and rs60910145, and their two-allele G1 haplotype (P \u3c 0.005). We did not observe significant evidence of association between non-diabetic CKD and any of the MYH9 variants or haplotypes after accounting for multiple testing in our sample. Conclusions: In conclusion, APOL1 risk variants are associated with non-diabetic forms of CKD among Nigerians of Yoruba ethnicity. Further information on APOL1/MYH9 variants may lead to screening programs, which could lead to earlier detection and interventions for non-diabetic kidney disease. © 2012 The Author(s)

The Efficacy of a Health Promotion Intervention for Indigenous Women: Reclaiming Our Spirits

Indigenous women globally are subjected to high rates of multiple forms of violence, including intimate partner violence (IPV), yet there is often a mismatch between available services and Indigenous women’s needs and there are few evidence-based interventions specifically designed for this group. Building on an IPV-specific intervention (Intervention for Health Enhancement After Leaving [iHEAL]), “Reclaiming Our Spirits” (ROS) is a health promotion intervention developed to address this gap. Offered over 6 to 8 months in a partnership between nurses and Indigenous Elders, nurses worked individually with women focusing on six areas for health promotion and integrated health-related workshops within weekly Circles led by an Indigenous Elder. The efficacy of ROS in improving women’s quality of life and health was examined in a community sample of 152 Indigenous women living in highly marginalizing conditions in two Canadian cities. Participants completed standard self-report measures of primary (quality of life, trauma symptoms) and secondary outcomes (depressive symptoms, social support, mastery, personal agency, interpersonal agency, chronic pain disability) at three points: preintervention (T1), postintervention (T2), and 6 months later (T3). In an intention-to-treat (ITT) analysis, Generalized Estimating Equations (GEE) were used to examine hypothesized changes in outcomes over time. As hypothesized, women’s quality of life and trauma symptoms improved significantly pre- to postintervention and these changes were maintained 6 months later. Similar patterns of improvement were noted for five of six secondary outcomes, although improvements in interpersonal agency were not maintained at T3. Chronic pain disability did not change over time. Within a context of extreme poverty, structural violence, and high levels of trauma and substance use, some women enrolled but were unable to participate. Despite the challenging circumstances in the women’s lives, these findings suggest that this intervention has promise and can be effectively tailored to the specific needs of Indigenous women

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Reclaiming our spirits: Development and pilot testing of a health promotion intervention for indigenous women who have experienced intimate partner violence

Indigenous women are subjected to high rates of multiple forms of violence, including intimate partner violence (IPV), in the context of ongoing colonization and neo-colonization. Health promotion interventions for women who experience violence have not been tailored specifically for Indigenous women. Reclaiming Our Spirits (ROS) is a health promotion intervention designed for Indigenous women living in an urban context in Canada. In this paper, we describe the development of the intervention, results of a pilot study, and the revised subsequent intervention. Building on a theory-based health promotion intervention (iHEAL) showing promising results in feasibility studies, ROS was developed using a series of related approaches including (a) guidance from Indigenous women with research expertise specific to IPV and Indigenous women’s experiences; (b) articulation of an Indigenous lens, including using Cree (one of the largest Indigenous language groups in North America) concepts to identify key aspects; and (c) interviews with Elders (n10) living in the study setting. Offered over 6-8 months, ROS consists of a Circle, led by an Indigenous Elder, and 1:1 visits with a Registered Nurse, focused on six areas for health promotion derived from previous research. Pilot testing with Indigenous women (n21) produced signs of improvement in most measures of health from pre- to post-intervention. Women found the pilot intervention acceptable and helpful but also offered valuable suggestions for improvement. A revised intervention, with greater structure within the Circle and nurses with stronger knowledge of Indigenous women’s experience and community health, is currently undergoing testing

Magnetic Energy Powers the Corona: How We Can Understand its 3D Storage & Release

The coronal magnetic field is the prime driver behind many as-yet unsolved mysteries: solar eruptions, coronal heating, and the solar wind, to name a few. It is, however, still poorly observed and understood. We highlight key questions related to magnetic energy storage, release, and transport in the solar corona, and their relationship to these important problems. We advocate for new and multi-point co-optimized measurements, sensitive to magnetic field and other plasma parameters, spanning from optical to $\gamma$-ray wavelengths, to bring closure to these long-standing and fundamental questions. We discuss how our approach can fully describe the 3D magnetic field, embedded plasma, particle energization, and their joint evolution to achieve these objectives.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 16 pages, 3 figure

COMPLETE: A flagship mission for complete understanding of 3D coronal magnetic energy release

COMPLETE is a flagship mission concept combining broadband spectroscopic imaging and comprehensive magnetography from multiple viewpoints around the Sun to enable tomographic reconstruction of 3D coronal magnetic fields and associated dynamic plasma properties, which provide direct diagnostics of energy release. COMPLETE re-imagines the paradigm for solar remote-sensing observations through purposefully co-optimized detectors distributed on multiple spacecraft that operate as a single observatory, linked by a comprehensive data/model assimilation strategy to unify individual observations into a single physical framework. We describe COMPLETE's science goals, instruments, and mission implementation. With targeted investment by NASA, COMPLETE is feasible for launch in 2032 to observe around the maximum of Solar Cycle 26.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 10 pages, 6 figures, 1 tabl

Improving Multi-Dimensional Data Formats, Access, and Assimilation Tools for the Twenty-First Century

Heliophysics image data largely relies on a forty-year-old ecosystem built on the venerable Flexible Image Transport System (FITS) data standard. While many in situ measurements use newer standards, they are difficult to integrate with multiple data streams required to develop global understanding. Additionally, most data users still engage with data in much the same way as they did decades ago. However, contemporary missions and models require much more complex support for 3D multi-parameter data, robust data assimilation strategies, and integration of multiple individual data streams required to derive complete physical characterizations of the Sun and Heliospheric plasma environment. In this white paper we highlight some of the 21$^\mathsf{st}$ century challenges for data frameworks in heliophysics, consider an illustrative case study, and make recommendations for important steps the field can take to modernize its data products and data usage models. Our specific recommendations include: (1) Investing in data assimilation capability to drive advanced data-constrained models, (2) Investing in new strategies for integrating data across multiple instruments to realize measurements that cannot be produced from single observations, (3) Rethinking old data use paradigms to improve user access, develop deep understanding, and decrease barrier to entry for new datasets, and (4) Investing in research on data formats better suited for multi-dimensional data and cloud-based computing.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 9 pages, 3 figure