Editorial comment

No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38466/1/1930060509_ftp.pd

The interaction of bladder-filling behavior and ureteral function

The interrelationship between bladder-filling behavior and ureteral delivery of urine into the bladder was studied in myelodysplastic children, in a primate neurogenic bladder-dysfunction model, and in a feline obstructive-uropathy model. All of these studies confirm the observation that intravesical pressure is the most important obstacle to ureteral delivery of urine into the bladder. Our concepts of ureteral function may need some revision. The findings in the obstructive feline model suggest that we should measure ureteral delivery of urine into the bladder in relation to intravescial pressure since this method may define ureteral reserve “power” better than either perfusion studies or dynamic renal scans.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47060/1/345_2005_Article_BF01580019.pd

Notes on Recent Cases

Notes on recent cases by Marc Wonderlin, H. J. Nester, Joseph P. McNamara, Edward P. McGuire, and Ivan J. LeBlanc

Management of difficult cases in female urology and neurourology at the Reed M. Nesbit society meeting festschrift in honor of Edward J. McGuire, MD

This is a panel discussion of seven complex urologic cases in female urology and neurourology. Differences in diagnosis and management are discussed by this international panel of experts. Neurourol. Urodynam. 29:S2–S12, 2010. © 2010 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71363/1/20795_ftp.pd

Rodent carcinogenesis bioassay with oxisuran, a selective immunosuppressive agent

The carcinogenic potential of oxisuran, a synthetic immunosuppressive agent, was studied for 80 weeks and 104 weeks in mice and rats, respectively. Groups of 50 mice and 70 rats of each sex received oxisuran at doses of 600, 240, and 40 mg/kg/day as dietary admixtures over the entire experimental period. Adequate survival rates allowed accurate statistical analysis of diagnosed neoplasia. Increased susceptibility to tumor development was not clearly demonstrated. In mice the only statistically significant increase in the incidence of malignancy was lung carcinomas in high dose females (P P P P < 0.01) contributed to an overall decrease in both benign tumors and in the combined benign and malignant tumor rates.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25114/1/0000547.pd

Carcinogenicity studies in rodents with ripazepam, a minor tranquilizing agent

The carcinogenesis potential of ripazepam, a benzodiazepine derivative, was studied in mice and rats for 78 and 104 weeks, respectively. Groups of 50 male and 50 female CD1 mice and CD rats each were given doses of 15 and 150 mg/kg of ripazepam in the diet. Survival rates were adequate for statistical analysis. Significant suppression of body weight gains occurred in rats but not in mice given 150 mg/kg/day. The compound failed to increase tumor rates or alter the average latency of neoplasms in the rat. In mice, the number of male animals with tumors was increased at 150 mg/kg and this was related to a significant increase in the number of animals with hepatocellular tumors. Hepatocellular tumors were increased also in female mice but the increase was not statistically significant. All but one of these hepatic neoplasms were hepatocellular adenomas and the one carcinoma had not metastasized. Other tumor types were not increased.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24852/1/0000279.pd

Fiberoptic microtransducer pressure technology: Uurodynamic implications

The FST 200 is a novel commercially available pressure measurement system that combines microtechnology and fiberoptics and is particularly well suited for invasive urodynamic studies. Pressure recording with this system is highly accurate and reproducible. The pressure curves obtained parallel those from standard water cystometry. Being small and portable, the system lends itself to invasive transurethral monitoring in the privacy of an examination room. Additionally, the 5F catheter size allows the performance of leak point pressures and pressure/flow voiding studies with minimal urethral stenting artifact often seen with larger catheters. The technical aspects of this system are presented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38473/1/1930120211_ftp.pd