14 research outputs found
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- Author
- Abraham R.
- Al-Chalabi A.
- Bass N.J.
- Bettens K.
- Brayne C.
- Brown K.S.
- Carrasquillo M.M.
- Collinge J.
- Craig David
- Cruchaga C.
- De Deyn P.P.
- Deloukas P.
- Dichgans M.
- Dowzell K.
- Engelborghs S.
- Fox N.
- Frolich L.
- Gerrish A.
- Gill M.
- Goate A.M.
- Guerreiro R.
- Gurling H.
- Gwilliam R.
- Hampel H.
- Hamshere M.L.
- Hardy J.
- Harold D.
- Heuser I.
- Hollingworth P.
- Holmans P.A.
- Holmes C.
- Hull M.
- Jessen F.
- Jockel K.H.
- Jones N.
- Kauwe J.S.K.
- Kehoe P.G.
- Klopp N.
- Kornhuber J.
- Lawlor B.
- Livingston G.
- Love S.
- Lovestone S.
- Lupton M.K.
- Lynch A.
- Maier W.
- Mann D.
- Mayo K.
- McGuinness Bernadette
- McQuillin A.
- Mead S.
- Moebus S.
- Morgan A.R.
- Morgan K.
- Morris J.C.
- Moskvina V.
- Muhleisen T.W.
- Nothen M.M.
- Nowotny P.
- O'Donovan M.
- Owen M.J.
- Pahwa J.S.
- Pankratz V.S.
- Passmore Peter A.
- Powell J.
- Proitsi P.
- Rossor M.
- Rubinsztein D.C.
- Rujescu D.
- Schurmann B.
- Shaw C.E.
- Sims R.
- Singleton A.B.
- Sleegers K.
- Smith A.D.
- Stretton A.
- Thomas C.
- Todd Stephen
- Tsolaki M.
- Van Broeckhoven C.
- Van Den Bussche H.
- Wichmann H.E.
- Williams A.
- Williams J.
- Wiltfang J.
- Younkin S.G.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/10/2009
- Field of study
Get PDFNew insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
- Anastasiou C.
- Andrade V.
- Andreassen Ole A.
- Andreoni S.
- Antequera M.
- Antikainen R.
- Antonell A.
- Anttonen V.
- Antúnez C.
- Aparicio H.J.
- Apostolova L.G.
- Appollonio I.
- Arcaro M.
- Archetti S.
- Armstrong N.J.
- Arnold S.E.
- Arosio B.
- Arvas M.
- Assogna F.
- Asthana S.
- Athanasiu L.
- Atwood C.S.
- Auge F.
- Auranen A.
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- Bailly H.
- Baldwin C.T.
- Banaj N.
- Baquero M.
- Barber R.C.
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- Barral S.
- Barral S.
- Bass N.
- Bass N.J.
- Bastiani P.
- Bayer A.
- Beach T.G.
- Becker J.T.
- Becker J.T.
- Becker T.
- Beecham G.W.
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- Below J.E.
- Below J.E.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Irish Journal Medical Science
- Author
- Publication venue
- Publication date
- 01/09/2003
- Field of study
No full textAn Ontology Definition Framework for Model Driven Development
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
No full textHistory on Trial
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
No full textRepresenting and Validating Digital Business Processes
- Author
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
Get PDFThe success of the semantic web relies heavily on ontologies. However, using ontologies for this specific area poses a number of new problems. One of these problems, extracting a high quality ontology from a given base ontology, is currently receiving increasing attention. Areas such as versioning, distribution and maintenance of ontologies often involve this problem. Here, a formalism is presented that enables grouping ontology extraction requirements into different categories, called optimization schemes. These optimization schemes provide a way to introduce quality in the extraction process. An overview of the formalism is discussed, as well as a demonstration of several example optimization schemes. Each of these optimization schemes meets a certain requirement, and consists of rules and algorithms. Examples of how the formalism is deployed to reach a high-quality result, called a materialized ontology view, are covered. The presented methodology provides a foundation for further developments, and shows the possibility of obtaining usable ontologies in a highly automated way
The Australian in Canberra, 1964–67
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- Publication venue
- 'SAGE Publications'
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No full text‘Breed out the colour’ or the importance of being white
- Author
- Austin Tony
- Birrell Robert
- Bleakley
- Broome
- Brunton Ron
- Carrodus J.A.
- Cleland J.B.
- Cochrane
- Cochrane Peter
- Cook
- Crotty Martin
- Goodall Heather
- Hancock W.K.
- Hirst John
- Jacobs
- Jacobs
- Jacobs
- Jacobs
- Jacobs Patricia
- Jones
- Jones Frederic Wood
- Manne
- Manne Robert
- Manne Robert
- Markus Andrew
- McGregor
- McGregor
- McGregor Russell
- McGuinness P.P.
- Morley
- Morley William
- Needham J.S.
- O'Malley Pat
- Paisley Fiona
- Paul
- Paul Diane
- Renan Ernest
- Roe Michael
- Rowley C.D.
- Rowse Tim
- Russell McGregor
- Smith
- Smith
- Stepan Nancy
- Tindale Norman
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textState strength and capitalist weakness: Manufacturing capital and the Tariff Board's attack on McEwenism, 1967–74
- Author
- ACMA
- AIDA
- Anderson K.
- Anderson R.W.C.
- Anthony J.D.
- Blank S.
- Block F.
- Brigden Report
- Bureau of Industry Economics
- Cochrane P.
- Coombs H.C.
- Fitzgerald T.M.
- Glezer L.
- Hall P.
- Head B.
- HEMA
- Industries Assistance Commission
- King J.M.C.
- Lindblom C.E.
- Loveday P.
- McGuinness P.P.
- MIAC
- Minutes of Meeting
- Minutes of Meeting
- Minutes of Meeting
- Nichols C.R.
- Ord W.K.
- PA. Management Consultants
- Rattigan G.A.
- Reuschemeyer D.
- Robinson P.
- Sav‐ille J.
- Skocpol T.
- Tariff Board
- Tsokhas K.
- Vemon Report
- Warhurst J.
- Whitlam E.G.
- Woods Alan
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textNew Right or Old Wrong? Ideology and Industrial Relations
- Author
- Attorney-General's Department
- Blackburn M.
- Braham Dabscheck
- CAI (Confederation of Australian Industry)
- Costello Peter
- Creighton W.B.
- Dabscheck Braham
- Dabscheck Braham
- Dabscheck Braham
- Davis Kevin
- DEIR (Department of Employment and Industrial Relations)
- Guille Howard
- Gutman G.O.
- Hagan Jim
- Henderson Gerard
- Hyde John
- Kemp D.A.
- Kochan Thomas A.
- Leard John
- Lee Margaret
- Loveday Peter
- Martin R.M.
- Martin Ross
- McCallum R.C.
- McEachern Doug
- McGuinness P.P.
- Mitchell R.J.
- Mitchell Richard
- Murray Robert
- Nairn Bede
- Ormonde Paul
- Rickard John
- Roe Michael
- Sawer Marian
- Shaw J.W.
- Stilwell Frank
- Stone J.O.
- Stone J.O.
- Stone John
- Stone John
- Stone John
- Stremski R.
- Thompson Yvonne
- Thurow Lester C.
- West Katherine
- Williams Pamela
- Williams Pamela
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
No full text
