International Evidence Review of Conditional (Suspended) Sentences: Final Report

This report reviews international use of conditional sentences, specifically understood to mean a criminal sentence of imprisonment which is suspended pending a person's satisfaction of specific criteria. These sentences are being considered in jurisdictions seeking ways of managing prison population growth. The laws and any information about use of such sentences among selected countries is considered in the first part. The second part reviews research on perceptions of such sentences, and community-based sentences generally. This research was requested by and submitted to the Scottish Government

Quantum squeezing cannot beat the standard quantum limit

Quantum entanglement between particles is expected to allow one to perform tasks that would otherwise be impossible. In quantum sensing and metrology, entanglement is often claimed to enable a precision that cannot be attained with the same number of particles and time, forgoing entanglement. Two distinct approaches exist: creation of entangled states that either i) respond quicker to the signal, or ii) are associated with lower noise and uncertainty. The second class of states are generally called squeezed states. Here we show that if our definition of success is -- a precision that is impossible to achieve without entanglement -- then the second approach cannot succeed. In doing so we show that a single non-separable squeezed state provides fundamentally no better precision, per unit time, than a single particle

Circulating markers of ageing and allostatic load: a slow train coming

Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing. They may also provide a mechanism which mediates the spread of allostatic load across the body over time, ultimately reflecting the immunological health and physiological status of tissues and organs. The interplay between exosomal microRNAs and ageing processes is still relatively unexplored, although circulating microRNAs have been linked to the regulation of a range of physiological and pathological processes and offer insight into mechanistic determinants of healthspan

Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous Parkinsonian mutant of PKCγ derived from a parental AS strain. P16INK4a expression was significantly higher in AS/AGU animals compared to age-matched AS controls (p < 0.001) and displayed segmental expression across various brain regions. The age-related expression of sirtuins similarly showed differences between strains and between brain regions. Our data clearly show segmental aging processes within the rat brain, and that these are accelerated in the AS/AGU mutant. The accelerated aging, Parkinsonian phenotype, and disruption to dopamine signalling in the basal ganglia in AS/AGU rats, suggests that this rat strain represents a useful model for studies of development and progression of Parkinson's disease in the context of biological aging and may offer unique mechanistic insights into the biology of aging

Did increasing the state pension age in Ireland affect the retirement rate of 65-year-olds? Quarterly Economic Commentary Special Article, Autumn 2017

In January 2014, the qualifying age for the Irish contributory state pension increased from 65 to 66 years. Individuals born after 1 January 1949 could no longer qualify for the pension at age 65, while individuals born before this date could still qualify, provided they had the required social insurance contributions. In this paper, we examine whether this change in the qualifying age had a causal effect on the retirement rate of 65-year-olds in Ireland. To do this, we compare the retirement rates of two groups of 65-year-olds in 2014; one group was born just after the cut-off date, thereby making them ineligible for the state pension at age 65, while the other group was born just before the cut-off date, making them potentially eligible, subject to meeting the insurance contribution requirements. We do not find clear evidence that the change in the retirement age had a causal effect on the retirement rate or the employment and unemployment rates of 65-year-olds in 2014