Study to design and develop remote manipulator system

Modeling of human performance in remote manipulation tasks is reported by automated procedures using computers to analyze and count motions during a manipulation task. Performance is monitored by an on-line computer capable of measuring the joint angles of both master and slave and in some cases the trajectory and velocity of the hand itself. In this way the operator's strategies with different transmission delays, displays, tasks, and manipulators can be analyzed in detail for comparison. Some progress is described in obtaining a set of standard tasks and difficulty measures for evaluating manipulator performance

Exact renormalization group and many-fermion systems

The exact renormalization group methods is applied to many fermion systems with short-range attractive force. The strength of the attractive fermion-fermion interaction is determined from the vacuum scattering length. A set of approximate flow equations is derived including fermionic and bosonic fluctuations. The numerical solutions show a phase transition to a gapped phase. The inclusion of bosonic fluctuations is found to be significant only in the small-gap regime.Comment: Talk, given by B. Krippa on the International Workshop "Meson2004", Cracow, Poland, 3 page

Proton polarisability contribution to the Lamb shift in muonic hydrogen at fourth order in chiral perturbation theory

We calculate the amplitude T_1 for forward doubly-virtual Compton scattering in heavy-baryon chiral perturbation theory, to fourth order in the chiral expansion and with the leading contribution of the gammaNDelta form factor. This provides a model-independent expression for the amplitude in the low-momentum region, which is the dominant one for its contribution to the Lamb shift. It allows us to significantly reduce the theoretical uncertainty in the proton polarisability contributions to the Lamb shift in muonic hydrogen. We also stress the importance of consistency between the definitions of the Born and structure parts of the amplitude. Our result leaves no room for any effect large enough to explain the discrepancy between proton charge radii as determined from muonic and normal hydrogen.Comment: 9 pages, 2 figures; added discussion of matching ChPT form factor onto dipole form at non-zero Q^2; no significant changes in result

Schubert calculus of Richardson varieties stable under spherical Levi subgroups

We observe that the expansion in the basis of Schubert cycles for $H^*(G/B)$ of the class of a Richardson variety stable under a spherical Levi subgroup is described by a theorem of Brion. Using this observation, along with a combinatorial model of the poset of certain symmetric subgroup orbit closures, we give positive combinatorial descriptions of certain Schubert structure constants on the full flag variety in type $A$. Namely, we describe $c_{u,v}^w$ when $u$ and $v$ are inverse to Grassmannian permutations with unique descents at $p$ and $q$, respectively. We offer some conjectures for similar rules in types $B$ and $D$, associated to Richardson varieties stable under spherical Levi subgroups of SO(2n+1,\C) and SO(2n,\C), respectively.Comment: Section 4 significantly shortened, and other minor changes made as suggested by referees. Final version, to appear in Journal of Algebraic Combinatoric

Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells

Regulatory T cells (Treg) are potent inhibitors of autoreactive T cells. The intracellular transcription factor FoxP3 controls the expression levels of a diverse set of genes and plays a critical role in programming functional Tregs. Although, antigen-specific Tregs are more potent than polyclonal Tregs in treating ongoing autoimmunity, phenotype plasticity associated with loss of FoxP3 expression in Tregs can lead to the conversion into antigen-specific effector T cells which might exacerbate autoimmune pathology. In this study, we designed a retroviral vector driving the expression of FoxP3 and a human HLA-DR-restricted TCR from the same promoter. Transduction of purified human Tregs revealed that all TCR-positive cells had elevated levels of FoxP3 expression, increased CD25 and CTLA4 expression and potent suppressive function. Elevated FoxP3 expression did not impair the in vitro expansion of engineered Tregs. Adoptive transfer into HLA-DR transgenic mice revealed that FoxP3+TCR engineered Tregs showed long-term persistence with stable FoxP3 and TCR expression. In contrast, adoptive transfer of Tregs engineered with TCR only resulted in the accumulation of TCR-positive, FoxP3-negative T cells which displayed antigen-specific effector function when stimulated with the TCR-recognised peptides. Our data indicate that forced expression of FoxP3 can prevent accumulation of antigen-specific effector T cells without impairing the engraftment and persistence of engineered Tregs

Comment on "Complete One-Loop Analysis of the Nucleon's Spin Polarisabilities"

We comment on the paper of Gellas et al, nucl-th/0002027, in which heavy baryon chiral perturbation theory results for the spin polarisabilities of the nucleon are given. That paper uses a definition which is different from the one used in papers by us, hep-ph/9908526, hep-ph/9909442 and hep-ph/0002133. In this comment we show that it is the latter definition, and not that of Gellas et al, that should be compared with the values of the polarisabilities extracted from dispersion relation analyses