10 research outputs found

    Radar Shape Modeling of Binary Near-Earth Asteroid (385186) 1994 AW1

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    (385186) 1994 AW1 is a potentially hazardous asteroid and the first near-Earth asteroid suspected to be a binary [1,2]. It made a close approach to Earth in July 2015 getting as close as 25 lunar distances on the 15th. This flyby was a great opportunity for observations in photometry [3] and radar. Continuous-wave (CW) and Delay-Doppler imaging modes were used, first at Goldstone for the 14-19 July period (0.066-0.700 au), and then by Arecibo for 20-30 July (0.075-0.126 au). A range resolution of 150 m was achieved at Goldstone in bistatic configuration with Green Bank Telescope, while monostatic observations in S-band (2380 MHz, 12.6 cm) at Arecibo were obtained at resolutions of 30 m and 75 m. The rotation period of the primary (2.52 h) and orbital period of the secondary (22 h) derived from optical light curves were confirmed by these observations. The primary is about 600 m in diameter and the secondary is about half of the primary's size. A more recent but relatively distant approach (July 8, 2022; 0.11 au) allowed CW spectra to be obtained at Goldstone [4]. We also obtained new light curves on 2023 January 13-24 while it was at V ~16-17 mag. We used the TRAPPIST-South (I40, Chile) and -North (Z53, Morocco) [5] to gather 10 light curves in total. For four of them, brightness drops indicate mutual events between 1994 AW1 and its satellite. We then used our radar and optical datasets with SHAPE [6] to perform shape modeling of the primary component. We will present our preliminary 3D shape model, pole coordinates and system density. References: [1] Pravec, P. and Hahn, G. (1997) Icarus, 127 [2] Mottola, S. et al. (1995) LPIC, 26 [3] Warner D. B. (2016) MPB, 43 [4] Brozovic, M. et al. (2022) DPS 54. [5] Jehin, E. et al. (2011) The Messenger 145, 2–6. [6] Magri, C. et al. (2007) Icarus 186, 152-177

    The Human Cell Atlas White Paper

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    The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating disease. It will help scientists understand how genetic variants impact disease risk, define drug toxicities, discover better therapies, and advance regenerative medicine. A resource of such ambition and scale should be built in stages, increasing in size, breadth, and resolution as technologies develop and understanding deepens. We will therefore pursue Phase 1 as a suite of flagship projects in key tissues, systems, and organs. We will bring together experts in biology, medicine, genomics, technology development and computation (including data analysis, software engineering, and visualization). We will also need standardized experimental and computational methods that will allow us to compare diverse cell and tissue types - and samples across human communities - in consistent ways, ensuring that the resulting resource is truly global. This document, the first version of the HCA White Paper, was written by experts in the field with feedback and suggestions from the HCA community, gathered during recent international meetings. The White Paper, released at the close of this yearlong planning process, will be a living document that evolves as the HCA community provides additional feedback, as technological and computational advances are made, and as lessons are learned during the construction of the atlas

    Surface Heterogeneity, Physical, and Shape Model of Near-Earth Asteroid (52768) 1998 OR2

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    peer reviewedOn 2020 April 29, the near-Earth object (52768) 1998 OR2 experienced a close approach to Earth at a distance of 16.4 lunar distances (LD). 1998 OR2 is a potentially hazardous asteroid of absolute magnitude H = 16.04 that can currently come as close to Earth as 3.4 LD. We report here observations of this object in polarimetry, photometry, and radar. Our observations show that the physical characteristics of 1998 OR2 are similar to those of both M- and S-type asteroids. Arecibo's radar observations provide a high radar albedo of sigma _OC = 0.29 ± 0.08, suggesting that metals are present in 1998 OR2 near-surface. We find a circular polarization ratio of μc = 0.291 ± 0.012, and the delay-Doppler images show that the surface of 1998 OR2 is a top-shape asteroid with large-scale structures such as large craters and concavities. The polarimetric observations display a consistent variation of the polarimetric response as a function of the rotational phase, suggesting that the surface of 1998 OR2 is heterogeneous. Color observations suggest an X-complex taxonomy in the Bus–DeMeo classification. Combining optical polarization, radar, and two epochs from the NEOWISE satellite observations, we derived an equivalent diameter of D = 1.80 ± 0.1 km and a visual albedo pv = 0.21 ± 0.02. Photometric and radar data provide a sidereal rotation period of P = 4.10872 ± 0.00001 hr, a pole orientation of (332.°3 ± 5°, 20.°7 ± 5°), and a shape model with dimensions of ({2.08}_{-0.10}^{+0.10}, {1.93}_{-0.10}^{+0.10},{1.60}_{-0.05}^{+0.05}) km

    The Human Cell Atlas White Paper

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    The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating disease. It will help scientists understand how genetic variants impact disease risk, define drug toxicities, discover better therapies, and advance regenerative medicine. A resource of such ambition and scale should be built in stages, increasing in size, breadth, and resolution as technologies develop and understanding deepens. We will therefore pursue Phase 1 as a suite of flagship projects in key tissues, systems, and organs. We will bring together experts in biology, medicine, genomics, technology development and computation (including data analysis, software engineering, and visualization). We will also need standardized experimental and computational methods that will allow us to compare diverse cell and tissue types - and samples across human communities - in consistent ways, ensuring that the resulting resource is truly global. This document, the first version of the HCA White Paper, was written by experts in the field with feedback and suggestions from the HCA community, gathered during recent international meetings. The White Paper, released at the close of this yearlong planning process, will be a living document that evolves as the HCA community provides additional feedback, as technological and computational advances are made, and as lessons are learned during the construction of the atlas

    La rééducation vocale

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    The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a nonsense mutation (T1264G; rs3211938) had undergone recent positive selection in the Yoruba of Nigeria. To investigate the global distribution of this putative selection event, we genotyped T1264G in 3420 individuals from 66 populations. We confirmed the high frequency of 1264G in the Yoruba (26%). However, the 1264G allele is less common in other African populations and absent from all non-African populations without recent African admixture. Using long-range linkage disequilibrium, we studied two West African groups in depth. Evidence for recent positive selection at the locus was demonstrable in the Yoruba, although not in Gambians. We screened 70 variants from across CD36 for an association with severe malaria phenotypes, employing a case-control study of 1350 subjects and a family study of 1288 parent-offspring trios. No marker was significantly associated with severe malaria. We focused on T1264G, genotyping 10 922 samples from four African populations. The nonsense allele was not associated with severe malaria (pooled allelic odds ratio 1.0; 95% confidence interval 0.89-1.12; P = 0.98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency
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