277 research outputs found
Lidar Validation Measurements at the NOAA Mauna Loa Observatory NDACC Station
NASA's Goddard Space Flight Center (GSFC) transported two lidar instruments to the NOAA facility at the Mauna Loa Observatory (MLO) on the Big Island of Hawaii, to participate in an official, extended validation campaign. This site is situated 11,141 ft. above sea level on the side of the mountain. The observatory has been making atmospheric measurements regularly since the 1950's, and has hosted the GSFC Stratospheric Ozone (STROZ) Lidar and the GSFC Aerosol and Temperature (AT) Lidar on several occasions, most recently between November, 2012 and November, 2015. The purpose of this extended deployment was to participate in Network for the Detection of Atmospheric Composition Change (NDACC) Validation campaigns with the JPL Stratospheric Ozone Lidar and the NOAA Temperature, Aerosol and Water Vapor instruments as part of the routine NDACC Validation Protocol
Metal Abundances in the Magellanic Stream
We report on the first metallicity determination for gas in the Magellanic
Stream, using archival HST GHRS data for the background targets Fairall 9, III
Zw 2, and NGC 7469. For Fairall 9, using two subsequent HST revisits and new
Parkes Multibeam Narrowband observations, we have unequivocally detected the
MSI HI component of the Stream (near its head) in SII1250,1253 yielding a
metallicity of [SII/H]=-0.55+/-0.06(r)+/-0.2(s), consistent with either an SMC
or LMC origin and with the earlier upper limit set by Lu et al. (1994). We also
detect the saturated SiII1260 line, but set only a lower limit of
[SiII/H]>-1.5. We present serendipitous detections of the Stream, seen in
MgII2796,2803 absorption with column densities of (0.5-1)x10^13 cm^-2 toward
the Seyfert galaxies III Zw 2 and NGC 7469. These latter sightlines probe gas
near the tip of the Stream (80 deg down-Stream of Fairall 9). For III Zw 2, the
lack of an accurate HI column density and the uncertain MgIII ionization
correction limits the degree to which we can constrain [Mg/H]; a lower limit of
[MgII/HI]>-1.3 was found. For NGC 7469, an accurate HI column density
determination exists, but the extant FOS spectrum limits the quality of the
MgII column density determination, and we conclude that [MgII/HI]>-1.5.
Ionization corrections associated with MgIII and HII suggest that the
corresponding [Mg/H] may range lower by 0.3-1.0 dex. However, an upward
revision of 0.5-1.0 dex would be expected under the assumption that the Stream
exhibits a dust depletion pattern similar to that seen in the Magellanic
Clouds. Remaining uncertainties do not allow us to differentiate between an LMC
versus SMC origin to the Stream gas.Comment: 30 pages, 8 figures, LaTeX (aaspp4), also available at
http://casa.colorado.edu/~bgibson/publications.html, accepted for publication
in The Astronomical Journa
Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots
AbstractExposures to heavy metals during fetal and perinatal development are of particular concern. Yet, the health impacts of exposures to toxic metals during these early stages of human development are not well understood due to the paucity of in vivo human data. Dried blood spots (DBS), collected by public health departments to screen for inherited metabolic errors and other disorders, are routinely archived and can be used for exposure assessment. Here we report an improved method for quantifying arsenic, lead, mercury and cadmium in newborn DBS to facilitate epidemiologic research on the health effects of early exposures to toxic metals
A method for exposing rodents to resuspended particles using whole-body plethysmography
BACKGROUND: Epidemiological studies have reported increased risks of cardiopulmonary-related hospitalization and death in association with exposure to elevated levels of particulate matter (PM) across a wide range of urban areas. In response to these findings, researchers have conducted animal inhalation exposures aimed at reproducing the observed toxicologic effects. However, it is technically difficult to quantitate the actual amount of PM delivered to the lung in such studies, and dose is frequently estimated using default respiration parameters. Consequently, the interpretation of PM-induced effects in rodents exposed via whole-body inhalation is often compromised by the inability to determine deposited dose. To address this problem, we have developed an exposure system that merges the generation of dry, aerosolized particles with whole-body plethysmography (WBP), thus permitting inhalation exposures in the unrestrained rat while simultaneously obtaining data on pulmonary function. RESULTS: This system was validated using an oil combustion-derived particle (HP12) at three nominal concentrations (3, 12, and 13 mg/m(3)) for four consecutive exposure days (6 hr/day); a single 6-hour exposure to 13 mg/m(3 )of HP12 was also conducted. These results demonstrated that the system was both reliable and consistent over these exposure protocols, achieving average concentrations that were within 10% of the targeted concentration. In-line filters located on the exhaust outlets of individual WBP chambers showed relative agreement in HP12 mass for each day and were not statistically different when compared to one another (p = 0.16). Temperatures and relative humidities were also similar between chambers during PM and air exposures. Finally, detailed composition analyses of both HP12 filter and bulk samples showed that grinding and aerosolization did not change particle chemistry. CONCLUSION: The results of this study demonstrate that it is possible to expose rodents to resuspended, dry PM via whole-body inhalation while these animals are maintained in WBP chambers. This new methodology should significantly improve the ability to assess dosimetry under minimally stressful exposure conditions
Consistent Pulmonary and Systemic Responses from Inhalation of Fine Concentrated Ambient Particles: Roles of Rat Strains Used and Physicochemical Properties
Several studies have reported health effects of concentrated ambient particles (CAP) in rodents and humans; however, toxicity end points in rodents have provided inconsistent results. In 2000 we conducted six 1-day exposure studies where spontaneously hypertensive (SH) rats were exposed to filtered air or CAPs (≤ 2.5 μm, 1,138–1,765 μg/m(3)) for 4 hr (analyzed 1–3 hr afterward). In seven 2-day exposure studies in 2001, SH and Wistar Kyoto (WKY) rats were exposed to filtered air or CAP (≤ 2.5 μm, 144–2,758 μg/m(3)) for 4 hr/day × 2 days (analyzed 1 day afterward). Despite consistent and high CAP concentrations in the 1-day exposure studies, no biologic effects were noted. The exposure concentrations varied among the seven 2-day exposure studies. Except in the first study when CAP concentration was highest, lavageable total cells and macrophages decreased and neutrophils increased in WKY rats. SH rats demonstrated a consistent increase of lavage fluid γ -glutamyltransferase activity and plasma fibrinogen. Inspiratory and expiratory times increased in SH but not in WKY rats. Significant correlations were found between CAP mass (microgram per cubic meter) and sulfate, organic carbon, or zinc. No biologic effects correlated with CAP mass. Despite low chamber mass in the last six of seven 2-day exposure studies, the levels of zinc, copper, and aluminum were enriched severalfold, and organic carbon was increased to some extent when expressed per milligram of CAP. Biologic effects were evident in those six studies. These studies demonstrate a pattern of rat strain–specific pulmonary and systemic effects that are not linked to high mass but appear to be dependent on CAP chemical composition
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