Unidentified Bodies and Mass-Fatality Management in Haiti: A Case Study of the January 2010 Earthquake with a Cross-Cultural Comparison

The following paper examines the January 2010 earthquake in Haiti as a case study to better understand what happens to unidentified bodies in mass-fatality management. The paper explores the literature on mass-fatality management, discusses the context of Haiti and the impact of the earthquake in this country, mentions the methods undertaken for this study, and then outlines the key findings from this particular disaster. The paper compares preliminary conclusions in Haiti to other incidents in India, Bangladesh and Sri Lanka, and concludes with a discussion of implications for research and practice.US National Science Foundation for a RAPID grant (Award # 1034799

The Transmembrane Domain of CEACAM1-4S Is a Determinant of Anchorage Independent Growth and Tumorigenicity

CEACAM1 is a multifunctional Ig-like cell adhesion molecule expressed by epithelial cells in many organs. CEACAM1-4L and CEACAM1-4S, two isoforms produced by differential splicing, are predominant in rat liver. Previous work has shown that downregulation of both isoforms occurs in rat hepatocellular carcinomas. Here, we have isolated an anchorage dependent clone, designated 253T-NT that does not express detectable levels of CEACAM1. Stable transfection of 253-NT cells with a wild type CEACAM1-4S expression vector induced an anchorage independent growth in vitro and a tumorigenic phenotype in vivo. These phenotypes were used as quantifiable end points to examine the functionality of the CEACAM1-4S transmembrane domain. Examination of the CEACAM1 transmembrane domain showed N-terminal GXXXG dimerization sequences and C-terminal tyrosine residues shown in related studies to stabilize transmembrane domain helix-helix interactions. To examine the effects of transmembrane domain mutations, 253-NT cells were transfected with transmembrane domain mutants carrying glycine to leucine or tyrosine to valine substitutions. Results showed that mutation of transmembrane tyrosine residues greatly enhanced growth in vitro and in vivo. Mutation of transmembrane dimerization motifs, in contrast, significantly reduced anchorage independent growth and tumorigenicity. 253-NT cells expressing CEACAM1-4S with both glycine to leucine and tyrosine to valine mutations displayed the growth-enhanced phenotype of tyrosine mutants. The dramatic effect of transmembrane domain mutations constitutes strong evidence that the transmembrane domain is an important determinant of CEACAM1-4S functionality and most likely by other proteins with transmembrane domains containing dimerization sequences and/or C-terminal tyrosine residues

Disasters, Development and Resilience: Exploring the Need for Comprehensive Vulnerability Management

BOOK ABSTRACT: This book offers a systematic, empirical examination of the concepts of disasters and sustainable economic development applied to many cases around the world. It presents comprehensive coverage of the complex and dynamic relationship between disaster and development, making a vital contribution to the literature on disaster management, disaster resilience and sustainable development. The book collects twenty-three chapters, examining theoretical issues and investigating practical cases on policy, governance, and lessons learned in dealing with different types of disasters (e.g., earthquakes, floods and hurricanes) in twenty countries and communities around the world.https://orc.library.atu.edu/atu_faculty_books/1073/thumbnail.jp