VEGA Pathfinder navigation for Giotto Halley encounter

Results of the VEGA Pathfinder concept which was used to successfully target the European Space Agnecy's Giotto spacecraft to a 600 km encounter with the comet Halley are presented. Pathfinder was an international cooperative navigation activity involving USSR, European and U.S. space agencies. The final Giotto targeting maneuver was based on a comet location determined from optical data acquired by the earlier arriving Soviet VEGA spacecraft. Inertial pointing angles extracted from optical images of the comet nucleus were combined with a precise estimate of the VEGA encounter orbits determined using VLBI data acquired by NASA's Deep Space Network to predict the location of Halley at Giotto encounter. This article describes the VLBI techniques used to determine the VEGA orbits and shows that the insensitivity of the VLBI data strategy to unmodeled dynamic error sources resulted in estimates of the VEGA orbits with an accuracy of 50 km

Black hole evaporation with separated fermions

In models with a low quantum gravity scale, a well-motivated reason to expect quark and lepton fields are localized but physically separated is to avoid proton decay. This could happen in a ``fat-brane'' or in an additional, orthogonal 1/TeV sized dimension in which the gauge and Higgs fields live throughout. Black holes with masses of order the quantum gravity scale are therefore expected to evaporate non-universally, preferentially radiating directly into quarks or leptons but not both. Should black holes be copiously produced at a future hadron collider, we find the ratio of final state jets to charged leptons to photons is 113:8:1, which differs from previous analyses that assumed all standard model fields live at the same point in the extra dimensional space.Comment: 5 pages, REVTe

Gaugephobic Higgs Signals at the LHC

The Gaugephobic Higgs model provides an interpolation between three different models of electroweak symmetry breaking: Higgsless models, Randall-Sundrum models, and the Standard Model. At parameter points between the extremes, Standard Model Higgs signals are present at reduced rates, and Higgsless Kaluza-Klein excitations are present with shifted masses and couplings, as well as signals from exotic quarks necessary to protect the Zbb coupling. Using a new implementation of the model in SHERPA, we show the LHC signals which differentiate the generic Gaugephobic Higgs model from its limiting cases. These are all signals involving a Higgs coupling to a Kaluza-Klein gauge boson or quark. We identify the clean signal $p p \to W^(i) \to W H$ mediated by a Kaluza-Klein W, which can be present at large rates and is enhanced for even Kaluza-Klein numbers. Due to the very hard lepton coming from the W decay, this signature has little background, and provides a better discovery channel for the Higgs than any of the Standard Model modes, over its entire mass range. A Higgs radiated from new heavy quarks also has large rates, but is much less promising due to very high multiplicity final states.Comment: 16 pages, 8 figure

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores

Abstract Background Preterm birth is a significant public health concern and exposure to phthalates has been shown to be associated with an increased odds of preterm birth. Even modest reductions in gestational age at delivery could entail morbid consequences for the neonate and analyzing data with this additional information may be useful. In the present analysis, we consider gestational age at delivery as our outcome of interest and examine associations with multiple phthalates. Methods Women were recruited early in pregnancy as part of a prospective, longitudinal birth cohort at the Brigham and Women’s Hospital in Boston, Massachusetts. Urine samples were collected at up to four time points during gestation for urinary phthalate metabolite measurement, and birth outcomes were recorded at delivery. From this population, we selected all 130 cases of preterm birth (< 37 weeks of gestation) as well as 352 random controls. We conducted analysis with both geometric average of the exposure concentrations across the first three visits as well as using repeated measures of the exposure. Two different time to event models were used to examine associations between nine urinary phthalate metabolite concentrations and time to delivery. Two different approaches to constructing a summative phthalate risk score were also considered. Results The single-pollutant analysis using a Cox proportional hazards model showed the strongest association with a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.09, 1.33) per interquartile range (IQR) change in average log-transformed mono-2-ethyl-5-carboxypentyl phthalate (MECPP) concentration. Using the accelerated failure time model, we observed a 1.19% (95% CI: 0.26, 2.11%) decrease in gestational age in association with an IQR change in average log-transformed MECPP. We next examined associations with an environmental risk score (ERS). The fourth quartile of ERS was significantly associated with a HR of 1.44 (95% CI: 1.19, 1.75) and a reduction of 2.55% (95% CI: 0.76, 4.30%) in time to delivery (in days) compared to the first quartile. Conclusions On average, pregnant women with higher urinary metabolite concentrations of individual phthalates have shorter time to delivery. The strength of the observed associations are amplified with the risk scores when compared to individual pollutants.https://deepblue.lib.umich.edu/bitstream/2027.42/144517/1/12940_2018_Article_400.pd

Mass Determination in SUSY-like Events with Missing Energy

We describe a kinematic method which is capable of determining the overall mass scale in SUSY-like events at a hadron collider with two missing (dark matter) particles. We focus on the kinematic topology in which a pair of identical particles is produced with each decaying to two leptons and an invisible particle (schematically, $pp\to YY+jets$ followed by each $Y$ decaying via $Y\to \ell X\to \ell\ell'N$ where $N$ is invisible). This topology arises in many SUSY processes such as squark and gluino production and decay, not to mention t\anti t di-lepton decays. In the example where the final state leptons are all muons, our errors on the masses of the particles $Y$, $X$ and $N$ in the decay chain range from 4 GeV for 2000 events after cuts to 13 GeV for 400 events after cuts. Errors for mass differences are much smaller. Our ability to determine masses comes from considering all the kinematic information in the event, including the missing momentum, in conjunction with the quadratic constraints that arise from the $Y$, $X$ and $N$ mass-shell conditions. Realistic missing momentum and lepton momenta uncertainties are included in the analysis.Comment: 41 pages, 14 figures, various clarifications and expanded discussion included in revised version that conforms to the version to be publishe

Initial determination of the spins of the gluino and squarks at LHC

In principle particle spins can be measured from their production cross sections once their mass is approximately known. The method works in practice because spins are quantized and cross sections depend strongly on spins. It can be used to determine, for example, the spin of the top quark. Direct application of this method to supersymmetric theories will have to overcome the challenge of measuring mass at the LHC, which could require high statistics. In this article, we propose a method of measuring the spins of the colored superpatners by combining rate information for several channels and a set of kinematical variables, without directly measuring their masses. We argue that such a method could lead to an early determination of the spin of gluino and squarks. This method can be applied to the measurement of spin of other new physics particles and more general scenarios.Comment: 23 pages, 8 figures, minor change

Radion effects on unitarity in gauge-boson scattering

The scalar field associated with fluctuations in the positions of the two branes, the ``radion'', plays an important role determining the cosmology and collider phenomenology of the Randall-Sundrum solution to the hierarchy problem. It is now well known that the radion mass is of order the weak scale, and that its couplings to standard model fields are order 1/TeV to the trace of the energy momentum tensor. We calculate longitudinal vector boson scattering amplitudes to explore the constraints on the radion mass and its coupling from perturbative unitarity. The scattering cross section can indeed become non-perturbative at energies prior to reaching the TeV brane cutoff scale, but only when some curvature-Higgs mixing on the TeV brane is present. We show that the coefficient of the curvature-Higgs mixing operator must be less than about 3 for the 4-d effective theory to respect perturbative unitarity up to the TeV brane cutoff scale. Mass bounds on the Higgs boson and the radion are also discussed.Comment: 17 pages, LaTeX, 5 eps figures, uses epsf.sty and axodraw.st

Phenomenology of the Little Higgs Model

We study the low energy phenomenology of the little Higgs model. We first discuss the linearized effective theory of the "littlest Higgs model" and study the low energy constraints on the model parameters. We identify sources of the corrections to low energy observables, discuss model-dependent arbitrariness, and outline some possible directions of extensions of the model in order to evade the precision electroweak constraints. We then explore the characteristic signatures to test the model in the current and future collider experiments. We find that the LHC has great potential to discover the new SU(2) gauge bosons and the possible new U(1) gauge boson to the multi-TeV mass scale. Other states such as the colored vector-like quark T and doubly-charged Higgs boson Phi^{++} may also provide interesting signals. At a linear collider, precision measurements on the triple gauge boson couplings could be sensitive to the new physics scale of a few TeV. We provide a comprehensive list of the linearized interactions and vertices for the littlest Higgs model in the appendices.Comment: 43 pages, 6 figures; v2: discussion clarified, typos corrected; v3: version to appear in PRD; v4: typos fixed in Feynman rule

Effects of genuine dimension-six Higgs operators

We systematically discuss the consequences of genuine dimension-six Higgs operators. These operators are not subject to stringent constraints from electroweak precision data. However, they can modify the couplings of the Higgs boson to electroweak gauge bosons and, in particular, the Higgs self-interactions. We study the sensitivity to which those couplings can be probed at future \ee linear colliders in the sub-TeV and in the multi-TeV range. We find that for $\sqrt s=500$ GeV with a luminosity of 1 ab$^{-1}$ the anomalous $WWH$ and $ZZH$ couplings may be probed to about the 0.01 level, and the anomalous $HHH$ coupling to about the 0.1 level.Comment: 21 pages, 17 figures; typos corrected and references adde

Effect of Loading Method on a Peptide Substrate Reporter in Intact Cells [post-print]

Studies of live cells often require loading of exogenous molecules through the cell membrane; however, effects of loading method on experimental results are poorly understood. Therefore, in this work, we compared three methods for loading a fluorescently labeled peptide into cells of the model organism Dictyostelium discoideum. We optimized loading by pinocytosis, electroporation, and myristoylation to maximize cell viability and characterized loading efficiency, localization, and uniformity. We also determined how the loading method affected measurements of enzyme activity on the peptide substrate reporter using capillary electrophoresis. Loading method had a strong effect on the stability and phosphorylation of the peptide. The half-life of the intact peptide in cells was 19 ± 2, 53 ± 15, and 12 ± 1 min, for pinocytosis, electroporation, and myristoylation, respectively. The peptide was phosphorylated only in cells loaded by electroporation. Fluorescence microscopy suggested that the differences between methods were likely due to differences in peptide localization