17 research outputs found
'Education, education, education' : legal, moral and clinical
This article brings together Professor Donald Nicolson's intellectual interest in professional legal ethics and his long-standing involvement with law clinics both as an advisor at the University of Cape Town and Director of the University of Bristol Law Clinic and the University of Strathclyde Law Clinic. In this article he looks at how legal education may help start this process of character development, arguing that the best means is through student involvement in voluntary law clinics. And here he builds upon his recent article which argues for voluntary, community service oriented law clinics over those which emphasise the education of students
Synchrotron XRD study of phase transforms in illitic clays to extract information on sigillata manufacturing processes
The phase transformations as a function of the temperature
of two natural illitic clays were investigated through
XRD measurements, ex situ at room temperature with conventional
set up and in situ with synchrotron radiation, in order to
understand the origin of the corundum phase, which is one of
the main characteristics of the red glaze (slip) of Terra Sigillata
from south Gaul. These clays were chosen on the basis of their
chemical composition and for the quality of vitrification in the
firing temperature range of sigillata (1030â1080 âŚC). Results
show that corundum can be formed above 1000 âŚC if the amount
of Mg is not too high. The corundum formation does not result
directly from the total decomposition of illite (< 900 âŚC)
but from the formation and disruption of an intermediate potassium
aluminum silicate phase. On the other hand, if chlorite is
present in the raw clay so that the amount of Mg > 3â4 wt. %,
this intermediate phase is not observed and only a spinel phase
is formed
Treatment strategies for tics in Tourette syndrome
Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterized by tics: repetitive, involuntary movements and vocalizations. These symptoms can have a significant impact on patientsâ daily functioning across many domains. Tics tend to be most severe in child and adolescent sufferers, so their presence has the potential to impact a period of life that is both critical for learning and is often associated with the experience of greater social tension and self-consciousness than adulthood. Furthermore, control over tics that lead to physical impairment or self-injurious behaviour is of vital importance in maintaining health and quality of life. There are numerous complicating factors in the prescription of treatment for tics, due to both the side effects associated with alleviating agents and patient characteristics, such as age and comorbid conditions. This review summarizes literature pertaining to the efficacy and safety of both traditionally prescribed and more modern medications. We also discuss the merits of behavioural and surgical techniques and highlight newer emerging treatments. Although treatment response is to some extent variable, there are a number of agents that are clearly useful as first-line treatments for TS. Other interventions may be of most benefit to patients exhibiting refractory tics or more specific symptom profiles
Avaliação de novos depĂłsitos de argilas do Estado da ParaĂba visando sua aplicação como matĂŠrias-primas cerâmicas
Approaches in the safety evaluations of veterinary antimicrobial agents in food to determine the effects on the human intestinal microflora
ANO5 gene analysis in a large cohort of patients with anoctaminopathy: confirmation of male prevalence and high occurrence of the common exon 5 gene mutation
Limb girdle muscular dystrophy type 2L or anoctaminopathy is a condition mainly characterized by adult onset proximal lower limb muscular weakness and raised CK values, due to recessive ANO5 gene mutations. An exon 5 founder mutation (c.191dupA) has been identified in most of the British and German LGMD2L patients so far reported. We aimed to further investigate the prevalence and spectrum of ANO5 gene mutations and related clinical phenotypes, by screening 205 undiagnosed patients referred to our molecular service with a clinical suspicion of anoctaminopathy. A total of 42 unrelated patients had two ANO5 mutations (21%), whereas 14 carried a single change. We identified 34 pathogenic changes, 15 of which are novel. The c.191dupA mutation represents 61% of mutated alleles and appears to be less prevalent in non-Northern European populations. Retrospective clinical analysis corroborates the prevalently proximal lower limb phenotype, the male predominance and absence of major cardiac or respiratory involvement. Identification of cases with isolated hyperCKaemia and very late symptomatic male and female subjects confirms the extension of the phenotypic spectrum of the disease. Anoctaminopathy appears to be one of the most common adult muscular dystrophies in Northern Europe, with a prevalence of about 20%â25% in unselected undiagnosed cases