5,996 research outputs found
Arm cavity resonant sideband control for laser interferometric gravitational wave detectors
We present a new optical control scheme for a laser interferometric gravitational wave detector that has a high degree of tolerance to interferometer spatial distortions and noise on the input light. The scheme involves resonating the rf sidebands in an interferometer arm cavity
Pulmonary Lobe Segmentation with Probabilistic Segmentation of the Fissures and a Groupwise Fissure Prior
A fully automated, unsupervised lobe segmentation algorithm is presented based on a probabilistic segmentation of the fissures and the simultaneous construction of a population model of the fissures. A two-class probabilistic segmentation segments the lung into candidate fissure voxels and the surrounding parenchyma. This was combined with anatomical information and a groupwise fissure prior to drive non-parametric surface fitting to obtain the final segmentation. The performance of our fissure segmentation was validated on 30 patients from the COPDGene cohort, achieving a high median F1-score of 0:90 and showed general insensitivity to filter parameters. We evaluated our lobe segmentation algorithm on the LOLA11 dataset, which contains 55 cases at varying levels of pathology. We achieved the highest score of 0:884 of the automated algorithms. Our method was further tested quantitatively and qualitatively on 80 patients from the COPDGene study at varying levels of functional impairment. Accurate segmentation of the lobes is shown at various degrees of fissure incompleteness for 96% of all cases. We also show the utility of including a groupwise prior in segmenting the lobes in regions of grossly incomplete fissures
Challenges in the registration of serial CT images from lung radiotherapy patients
Radiation induced lung damage is an unwanted side effect of
curative radiotherapy. Radiological findings are often used as indicators
of lung damage, which is identifiable as changes in the baseline imaging
features (e.g., anatomy shape, intensity and texture). In this work we
qualitatively investigate the challenges in registering baseline and followup CT images acquired 12 months after radiotherapy
RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1.
Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis.
BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events. Prior studies of cardiovascular disease risk factors and CAC progression have been limited by short follow-up or restricted to patients with advanced disease.Methods and resultsWe examined cardiovascular disease risk factors and CAC progression in a prospective multiethnic cohort study. CAC was measured 1 to 4 times (mean 2.5 scans) over 10 years in 6810 adults without preexisting cardiovascular disease. Mean CAC progression was 23.9 Agatston units/year. An innovative application of mixed-effects models investigated associations between cardiovascular disease risk factors and CAC progression. This approach adjusted for time-varying factors, was flexible with respect to follow-up time and number of observations per participant, and allowed simultaneous control of factors associated with both baseline CAC and CAC progression. Models included age, sex, study site, scanner type, and race/ethnicity. Associations were observed between CAC progression and age (14.2 Agatston units/year per 10 years [95% CI 13.0 to 15.5]), male sex (17.8 Agatston units/year [95% CI 15.3 to 20.3]), hypertension (13.8 Agatston units/year [95% CI 11.2 to 16.5]), diabetes (31.3 Agatston units/year [95% CI 27.4 to 35.3]), and other factors.ConclusionsCAC progression analyzed over 10 years of follow-up, with a novel analytical approach, demonstrated strong relationships with risk factors for incident cardiovascular events. Longitudinal CAC progression analyzed in this framework can be used to evaluate novel cardiovascular risk factors
Atom lithography using MRI-type feature placement
We demonstrate the use of frequency-encoded light masks in neutral atom
lithography. We demonstrate that multiple features can be patterned across a
monotonic potential gradient. Features as narrow as 0.9 microns are fabricated
on silicon substrates with a metastable argon beam. Internal state manipulation
with such a mask enables continuously adjustable feature positions and feature
densities not limited by the optical wavelength, unlike previous light masks.Comment: 4 pages, 4 figure
Narrow-line magneto-optical cooling and trapping of strongly magnetic atoms
Laser cooling on weak transitions is a useful technique for reaching
ultracold temperatures in atoms with multiple valence electrons. However, for
strongly magnetic atoms a conventional narrow-line magneto-optical trap (MOT)
is destabilized by competition between optical and magnetic forces. We overcome
this difficulty in Er by developing an unusual narrow-line MOT that balances
optical and magnetic forces using laser light tuned to the blue side of a
narrow (8 kHz) transition. The trap population is spin-polarized with
temperatures reaching below 2 microkelvin. Our results constitute an
alternative method for laser cooling on weak transitions, applicable to
rare-earth-metal and metastable alkaline earth elements.Comment: To appear in Phys. Rev. Lett. 4 pages, 5 figure
The ACIGA Data Analysis programme
The Data Analysis programme of the Australian Consortium for Interferometric
Gravitational Astronomy (ACIGA) was set up in 1998 by the first author to
complement the then existing ACIGA programmes working on suspension systems,
lasers and optics, and detector configurations. The ACIGA Data Analysis
programme continues to contribute significantly in the field; we present an
overview of our activities.Comment: 10 pages, 0 figures, accepted, Classical and Quantum Gravity,
(Proceedings of the 5th Edoardo Amaldi Conference on Gravitational Waves,
Tirrenia, Pisa, Italy, 6-11 July 2003
Bod1, a novel kinetochore protein required for chromosome biorientation
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule–kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles
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