1,464 research outputs found
PrEP in Scotland: Report by the Scottish HIV Pre-Exposure Prophylaxis Short Life Working Group
Positron-molecule interactions: resonant attachment, annihilation, and bound states
This article presents an overview of current understanding of the interaction
of low-energy positrons with molecules with emphasis on resonances, positron
attachment and annihilation. Annihilation rates measured as a function of
positron energy reveal the presence of vibrational Feshbach resonances (VFR)
for many polyatomic molecules. These resonances lead to strong enhancement of
the annihilation rates. They also provide evidence that positrons bind to many
molecular species. A quantitative theory of VFR-mediated attachment to small
molecules is presented. It is tested successfully for selected molecules (e.g.,
methyl halides and methanol) where all modes couple to the positron continuum.
Combination and overtone resonances are observed and their role is elucidated.
In larger molecules, annihilation rates from VFR far exceed those explicable on
the basis of single-mode resonances. These enhancements increase rapidly with
the number of vibrational degrees of freedom. While the details are as yet
unclear, intramolecular vibrational energy redistribution to states that do not
couple directly to the positron continuum appears to be responsible for these
enhanced annihilation rates. Downshifts of the VFR from the vibrational mode
energies have provided binding energies for thirty species. Their dependence
upon molecular parameters and their relationship to positron-atom and
positron-molecule binding energy calculations are discussed. Feshbach
resonances and positron binding to molecules are compared with the analogous
electron-molecule (negative ion) cases. The relationship of VFR-mediated
annihilation to other phenomena such as Doppler-broadening of the gamma-ray
annihilation spectra, annihilation of thermalized positrons in gases, and
annihilation-induced fragmentation of molecules is discussed.Comment: 50 pages, 40 figure
Good practices for a literature survey are not followed by authors while preparing scientific manuscripts
The number of citations received by authors in scientific journals has become
a major parameter to assess individual researchers and the journals themselves
through the impact factor. A fair assessment therefore requires that the
criteria for selecting references in a given manuscript should be unbiased with
respect to the authors or the journals cited. In this paper, we advocate that
authors should follow two mandatory principles to select papers (later
reflected in the list of references) while studying the literature for a given
research: i) consider similarity of content with the topics investigated, lest
very related work should be reproduced or ignored; ii) perform a systematic
search over the network of citations including seminal or very related papers.
We use formalisms of complex networks for two datasets of papers from the arXiv
repository to show that neither of these two criteria is fulfilled in practice
Shadowing in the nuclear photoabsorption above the resonance region
A model based on the hadronic fluctuations of the real photon is developed to
describe the total photonucleon and photonuclear cross sections in the energy
region above the nucleon resonances. The hadronic spectral function of the
photon is derived including the finite width of vector-meson resonances and the
quark-antiquark continuum. The shadowing effect is evaluated considering the
effective interaction of the hadronic component with the bound nucleons within
a Glauber-Gribov multiple scattering theory. The low energy onset of the
shadowing effect is interpreted as a possible signature of a modification of
the hadronic spectral function in the nuclear medium. A decrease of the
-meson mass in nuclei is suggested for a better explanation of the
experimental data.Comment: 8 pages, 7 figure
Itinerant spin excitations near the hidden order transition in URu2Si2
By means of neutron scattering we show that the high-temperature precursor to
the hidden order state of the heavy fermion superconductor URuSi
exhibits heavily damped incommensurate paramagnons whose strong energy
dispersion is very similar to that of the long-lived longitudinal f-spin
excitations that appear below T. Since the underlying local f-exchange is
preserved we expect only the f-d interactions to change across the phase
transition and to cause the paramagnetic damping. The damping exhibits
single-ion behavior independent of wave vector and vanishes below the hidden
order transition. We suggest that this arises from a transition from valence
fluctuations to a hybridized f-d state below T. Here we present evidence
that the itinerant excitations, like those in chromium, are due to Fermi
surface nesting of hole and electron pockets so that the hidden order phase
likely originates from a Fermi-surface instability. We identify wave vectors
that span nested regions of a band calculation and that match the neutron spin
crossover from incommensurate to commensurate on approach to the hidden order
phase.Comment: 4 pages, 4 figures, to be submitted to PR
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs through unknown mechanisms. Comparing human genome binding by these viral transcription factors, we discovered that 25% of binding sites were shared by EBNA 2 and the EBNA 3s and were located predominantly in enhancers. Moreover, 80% of potential EBNA 3A, 3B or 3C target genes were also targeted by EBNA 2, implicating extensive interplay between EBNA 2 and 3 proteins in cellular reprogramming. Investigating shared enhancer sites neighbouring two new targets (WEE1 and CTBP2) we discovered that EBNA 3 proteins repress transcription by modulating enhancer-promoter loop formation to establish repressive chromatin hubs or prevent assembly of active hubs. Re-ChIP analysis revealed that EBNA 2 and 3 proteins do not bind simultaneously at shared sites but compete for binding thereby modulating enhancer-promoter interactions. At an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular basis for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors
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Properties of Ni-Al under shock loading
New models for the dynamic response of materials will be based increasingly on better understanding and representation of processes occurring at the microstructural level. These developments require advances in diagnostics and models which can be applied explicitly to microstructural response. Various phenomena occur at the microstructural level which are generally ignored or averaged out in continuum-level models. One example of such 'irregular hydrodynamics' is the roughness imparted to a shock wave as it propagates through a polycrystalline material. We have developed imaging techniques to study spatial variations in shock propagation through polycrystalline materials. In order to interpret spatially-resolved data from polycrystal samples, we need to compare with simulations which represent the microstructure. Here we describe work undertaken to develop a model of the dynamic response of individual grains. The material chosen was Ni-Al alloy, because it exhibits a relatively large degree of elastic anisotropy, and it is relatively easy to manufacture
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