Advanced composite elevator for Boeing 727 aircraft. Volume 1: Technical summary

The design, development, analysis, and testing activities and results that were required to produce five and one-half shipsets of advanced composite elevators for Boeing 727 aircraft are summarized. During the preliminary design period, alternative concepts were developed. After selection of the best design, detail design and basic configuration improvements were evaluated. Five and one-half shipsets were manufactured. All program goals (except competitive cost demonstration) were accomplished when our design met or exceeded all requirements, criteria, and objectives

C-axis electronic Raman scattering in Bi_2Sr_2CaCu_2O_{8+\delta}

We report a c-axis-polarized electronic Raman scattering study of Bi_2Sr_2CaCu_2O_{8+\delta} single crystals. In the normal state, a resonant electronic continuum extends to 1.5 eV and gains significant intensity as the incoming photon energy increases. In the superconducting state, a coherence 2\Delta peak appears around 50 meV, with a suppression of the scattering intensity at frequencies below the peak position. The peak energy, which is higher than that seen with in-plane polarizations, signifies distinctly different dynamics of quasiparticle excitations created with out-of-plane polarization.Comment: 12 pages, REVTEX, 3 postscript figure

Mathematical and computer modeling of electro-optic systems using a generic modeling approach

The conventional approach to modelling electro-optic sensor systems is to develop separate models for individual systems or classes of system, depending on the detector technology employed in the sensor and the application. However, this ignores commonality in design and in components of these systems. A generic approach is presented for modelling a variety of sensor systems operating in the infrared waveband that also allows systems to be modelled with different levels of detail and at different stages of the product lifecycle. The provision of different model types (parametric and image-flow descriptions) within the generic framework can allow valuable insights to be gained

Biodiversity of the Colorado State University lands

Prepared for: Colorado State University Facilities Management.June 2022.Includes bibliographical references.During the academic year of 2021-2022, the Colorado Natural Heritage Program (CNHP) was contracted by CSU Facilities Management to complete a biodiversity survey of the CSU lands. This assessment will be used by Facilities Management to self-report on the Biodiversity component of the Operations category in the STARS (Sustainability, Tracking, Assessment, & Ratings System) report. This report assesses endangered and vulnerable species (including migratory species) on CSU-owned and managed lands and areas of biodiversity importance on CSU-owned and managed lands. An additional aim of this project was to include students in the geospatial analysis, research, and field data collection efforts, thereby lowering project costs and providing mentorship and experience to the students. Biodiversity was assessed through a geospatial environmental review of the properties which includes documented and potential occurrences of regulatory species and other species of concern within the property and a 1-mile buffer, assessment of the conservation areas adjacent to the property and within a buffer, and the diversity and acreage of wetlands and other ecosystem types. The conservation value of each property, based on a Return-on-Investment report, is presented. Geospatial data area used to evaluate climate resiliency and landscape disturbance. Further research into species on the largest and most well-studied properties is presented, along with results of field work. Colorado State University holds 32 individual properties, spanning 14 counties across Colorado, covering a total of 3,943 hectares. Properties held by CSU had 303 documented occurrences of regulatory species and other species of concern within 1 mile returned in the environmental review; additionally, potential habitat was returned for another 2210 regulatory and other species of concern from a combination of range maps, general precision CNHP element occurrence records, and models. Through the many metrics of biodiversity assessed, several properties stood out; these included the Eastern Colorado Research Center, the Mountain Campus, Foothills, Horsetooth, and the Environmental Learning Center. At the Eastern Colorado Research Center, a combination of research field work recorded 187 species as visual observations and/or within a modeled area. At the Mountain Campus, student research and field work recorded a total of 1,044 species as visual observations and/or within a modeled area, with 754 Animalia species, 273 Plantae species and 17 Fungi species. Along with providing information on the biodiversity on the CSU lands, this project provided educational value to CSU students and facilitated the creation of a storymap to showcase the biodiversity of CSU lands to the public and stakeholders. The biodiversity assessment suggests several actions which could be taken to protect, enhance, or restore the biodiversity found on CSU lands and identified properties with possible conservation gains through enhancement and restoration.June 2022

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer

Elevated c-Src protein expression has been shown in breast cancer and <i>in vitro</i> evidence suggests a role in endocrine resistance. To investigate whether c-Src is involved in endocrine resistance, we examined the expression of both total and activated c-Src in human breast cancer specimens from a cohort of oestrogen receptor (ER)-positive tamoxifen-treated breast cancer patients. Tissue microarray technology was employed to analyse 262 tumour specimens taken before tamoxifen treatment. Immunohistochemistry using total c-Src and activated c-Src antibodies was performed. Kaplan–Meier survival curves were constructed and log-rank test were performed. High level of nuclear activated Src was significantly associated with improved overall survival (<i>P</i>=0.047) and lower recurrence rates on tamoxifen (<i>P</i>=0.02). Improved patient outcome was only seen with activated Src in the nucleus. Nuclear activated Src expression was significantly associated with node-negative disease and a lower NPI (<i>P</i><0.05). On subgroup analysis, only ER-positive/progesterone receptor (PgR)-positive tumours were associated with improved survival (<i>P</i>=0.004). This shows that c-Src activity is increased in breast cancer and that activated Src within the nucleus of ER-positive tumours predicts an improved outcome. In ER/PgR-positive disease, activated Src kinase does not appear to be involved in <i>de novo</i> endocrine resistance. Further study is required in ER-negative breast cancer as this may represent a cohort in which it is associated with poor outcome

Effective Soft-Core Potentials and Mesoscopic Simulations of Binary Polymer Mixtures

Mesoscopic molecular dynamics simulations are used to determine the large scale structure of several binary polymer mixtures of various chemical architecture, concentration, and thermodynamic conditions. By implementing an analytical formalism, which is based on the solution to the Ornstein-Zernike equation, each polymer chain is mapped onto the level of a single soft colloid. From the appropriate closure relation, the effective, soft-core potential between coarse-grained units is obtained and used as input to our mesoscale simulations. The potential derived in this manner is analytical and explicitly parameter dependent, making it general and transferable to numerous systems of interest. From computer simulations performed under various thermodynamic conditions the structure of the polymer mixture, through pair correlation functions, is determined over the entire miscible region of the phase diagram. In the athermal regime mesoscale simulations exhibit quantitative agreement with united atom simulations. Furthermore, they also provide information at larger scales than can be attained by united atom simulations and in the thermal regime approaching the phase transition.Comment: 19 pages, 11 figures, 3 table

Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

We report on the first measurement of 39Ar in argon from underground natural gas reservoirs. The gas stored in the US National Helium Reserve was found to contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be <=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon (39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most important backgrounds in argon detectors for WIMP dark matter searches. The findings reported demonstrate the possibility of constructing large multi-ton argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table

Concept of operations for data fusion visualization

Situational awareness in the operations and supervision of a industrial system means that decision making entity, whether machine or human, have the important data presented in a timely manner. An optimal presentation of information such that the operator has the best opportunity accurately interpret and react to anomalies due to system degradation, failures or adversaries. Anticipated problems are a matter for system design; however, the paper will focus on concepts for situational awareness enhancement for a human operator when the unanticipated or unaddressed event types occur. Methodology for human machine interface development and refinement strategy is described for a synthetic fuels plant model. A novel concept for adaptively highlighting the most interesting information in the system and a plan for testing the methodology is described