Loss and Termination in the Development of a Resident Group

Separation and loss experiences are major issues in psychotherapy, but role identity and intimacy are considered the tasks of therapists in training. Experiential groups are advocated during training to enhance coping skills and to teach group process. Focusing on separations in a group setting can highlight that loss is inevitable at any stage of life. The group experience also adds personal meaning to the importance of loss as a training issue. If the group has sufficient time to develop, the members will be able to observe the wide range of responses possible in their peers. We describe the effects of loss, separation, and termination as experienced in a group of psychiatric residents during various stages of group development

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

C2H2 zinc fingers are found in several key transcriptional regulators in the immune system. However, these proteins usually contain more fingers than are needed for sequence-specific DNA binding, which suggests that different fingers regulate different genes and functions. Here we found that mice lacking finger 1 or finger 4 of Ikaros exhibited distinct subsets of the hematological defects of Ikaros-null mice. Most notably, the two fingers controlled different stages of lymphopoiesis, and finger 4 was selectively required for tumor suppression. The distinct defects support the hypothesis that only a small number of genes that are targets of Ikaros are critical for each of its biological functions. The subcategorization of functions and target genes by mutagenesis of individual zinc fingers will facilitate efforts to understand how zinc-finger transcription factors regulate development, immunity and disease