1,248 research outputs found

    Ejectives in Scottish English: a social perspective

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    This paper presents the results of an analysis of the realization of word-final /k/ in a sample of read and casual speech by 28 female pupils from a single-sex Glaswegian high school. Girls differed in age, socioeconomic background, and ethnicity. Ejectives were the most usual variant for /k/ in both speech styles, occurring in the speech of every pupil in our sample. Our narrow auditory analysis revealed a continuum of ejective production, from weak to intense stops. Results from multinomial logistic regression show that ejective production is promoted by phonetic, linguistic and interactional factors: ejectives were used more in read speech, when /k/ occurred in the /-Ƌk/ cluster (e.g. tank), and when the relevant word was either at the end of a clause or sentence, or in turn-final position. At the same time, significant interactions between style, and position in turn, and the social factors of age and ethnicity, show that the use of ejectives by these girls is subject to a fine degree of sociolinguistic control, alongside interactional factors. Finally, cautious comparison of these data with recordings made in 1997 suggests that these results may also reflect a sound change in progress, given the very substantial real-time increase in ejective realizations of /k/ in Glasgow over the past fourteen years

    Key Concepts in Family Studies

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    Taken from the book to be published by Sage in December 2010, this document provides the Introduction to the book, in which the authors discuss issues in Family Studies as a contemporary field of academic and professional work. Their discussion includes: some of the different positions adopted by researchers towards the use of the language of 'family'; the broad themes generally included in this field of study; and dilemmas in evaluations of, and interventions in, family lives

    Apoptosis induced by cancer chemotherapeutic drugs and its genetic suppression

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    Apoptosis can be distinguished from necrosis, the classical form of cell death, by several morphological and biochemical criteria. Apoptotic cells, but not necrotic cells, show early condensation of chromatin as well as endonuclease activation resulting in cleavage of the nuclear DNA into oligonucleosomal fragments. Both physiological and low level cytotoxic stimuli have been shown to induce apoptosis, which in some cell models can be suppressed by inhibitors of protein and RNA synthesis. The concept of the cell being actively involved in its own death, combined with the demonstration that factors which alter the rate of cell death, such as the proto-oncogene bcl-2, can directly affect the number of cells within a population, has resulted in the identification of cell death alongside proliferation and differentiation as a means for controlling celi population growth. The purpose of this study was to determine if bcl-2 and the Epstein-Barr virus gene BHRF1, which share 25% primary amino acid sequence homology, could suppress apoptosis in response to a variety of anti-cancer treatments. After demonstrating apoptotic cell death on treatment with chemotherapeutic agents in an IL-3 dependent cell line (FDCP-1) and three different EBV genome-positive Burkitt's lymphoma cell lines, the survival of EBV-BL cell lines expressing either exogenous bcl-2 or BHRF1 was examined. Suppression of apoptosis in response to treatment with chemotherapeutic drugs or y radiation was clearly shown in EBVBL cells expressing bcl-2 or BHRF1 when compared to control transfectants. This study has further confirmed that BHRF1 is functionally homologous to bcl-2, suggesting that BHRF1 may act to prevent apoptosis during EBV infection. Suppression of chemotherapeutic drug induced cell death by either bcl-2 or BHRF1 also represents a novel form of drug resistance and may form an alternative mechanism by which multidrug resistance may arise during chemotherapy. The identification and investigation of other genes which produce suppression of apoptosis is also important in order to determine the extent of involvement of apoptotic suppression in the transformation to the malignant state and in the acquisition of multidrug resistance. A protocol to screen for 'apoptosis-suppressed cells' in the FDCP-1 E -3 dependent cell line was developed to identify new genes involved in the pathway(s) of apoptosis

    Embodied relationality and caring after death

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    We explore contested meanings around care and relationality through the underexplored case of caring after death, throwing the relational significance of ‘bodies’ into sharp relief. While the dominant social imaginary and forms of knowledge production in many affluent western societies take death to signify an absolute loss of the other in the demise of their physical body, important implications follow from recognising that embodied relational experience can continue after death. Drawing on a model of embodied relational care encompassing a ‘me’, a ‘you’ and an ‘us’, we argue that after death ‘me’ and ‘us’ remain (though changed) while crucial dimensions of ‘you’ persist too. In unravelling the binary divide between living and dead bodies, other related dichotomies of mind/body, self/other, internal/external, and nature/social are also called into question, extending debates concerning relationality and openness between living bodies. Through an exploration of autobiographical accounts and empirical research, we argue that embodied relationality expresses how connectedness is lived out after death in material practices and felt experiences

    “Why can’t they be in the community?” A policy and practice analysis of transforming care for offenders with intellectual disability

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    Purpose – The purpose of this paper is to describe key policy and practice issues regarding a significant subgroup of people with intellectual disability – those with offending behaviour being treated in forensic hospitals. Design/methodology/approach – The reasons why psychiatrists continue to be involved in the treatment of people with intellectual disability and mental health or behavioural problems and the factors that may lead to patients needing hospital admission are examined. Using two illustrative examples, three key questions – containment vs treatment, hospital care vs conditional discharge and hospital treatment vs using deprivation of liberty safeguards usage in the community are explored. Findings – Patients with intellectual disability, mental health problems and offending behaviours who are treated within forensic inpatient units tend to have long lengths of stay. The key variable that mediates this length of stay is the risk that they pose to themselves or others. Clinicians work within the framework of mental health law and have to be mindful that pragmatic solutions to hasten discharge into the community may not fall within the law. Originality/value – This paper makes practical suggestions for the future on how to best integrate hospital and community care for people with intellectual disability, mental health and offending behaviours. </jats:sec
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