Introduction

On a night like this I remember the childwho came with fifteen summers to her name,and she lay down alone at my feetwithout midwife or doctor or friend to hold her handand she pushed her secret out into the night,far from the town tucked up in little scandals,bargains struck, words broken, prayers, promises,and though she cried out to me in extremisI did not move It is a confusing feeling – somewhere between diarrhoea and sex – this grief that is almost genital. This issue of Études irlandais..

Dan Wylie and Craig MacKenzie, eds. “No Other World”: Essays on the Life-Work of Don Maclennan

This collection brings together intimate reflections and academic articles on a lesser-known and, the contributors argue, to date underrated South African academic, playwright, fiction writer, and poet, Don Maclennan (1929-2009). Born in England, Maclennan moved to South Africa when he was still a boy, and although he subsequently studied for a short while at Edinburgh University, and lived and taught for a couple of years in the United States, his home became South Africa. He held temporary ..

Between the Shadows

The essays contained in John Wilson Foster’s latest publication, most of which are slightly revised versions of papers, talks and previously published articles, cover a period of almost fifteen years. This time span is not unproblematic, especially given the significant political evolution which has taken place in the north over that period. In the preface, however, Foster pre-empts any criticism of his decision to let the articles stand in their original form by claiming that despite their p..

« Irish Culture and Colonial Modernity 1800-2000: The Transformation of Oral Space », David Lloyd

In his latest monograph, David Lloyd offers a stimulating analysis of the ways in which, as the subtitle of his work indicates, the oral space in Ireland has been profoundly and radically altered over the last two hundred years or so. Extremely erudite, Lloyd’s work retraces the transformation of Irish oral spaces from the clachan to the H-Blocks, via the public house, situating this metamorphosis within the context of capitalist expansion and colonial control and exploring the multifarious e..

Introduction

On a night like this I remember the childwho came with fifteen summers to her name,and she lay down alone at my feetwithout midwife or doctor or friend to hold her handand she pushed her secret out into the night,far from the town tucked up in little scandals,bargains struck, words broken, prayers, promises,and though she cried out to me in extremisI did not move It is a confusing feeling – somewhere between diarrhoea and sex – this grief that is almost genital. This issue of Études irlandais..

Introduction

“The Blessed Virgin and Cathleen Ní Houlihan were probably the two most dominant female icons in my thinking – the one being religious and the other poetic and romantic”, Edna O’Brien “a new languageis a kind of scar and heals after a while into a passable imitation of what went before”, Eavan Boland The decline of second-wave feminism in Western societies, the legacy of neo-liberal capitalism in general and of the Celtic Tiger in particular, and the emergence of a more liberal Irish society ..

Nadine Gordimer: De-Linking, Interrupting, Severing. Introduction

In a reflection about her own positionality, seen against the provisional and uncertain background of the “breaches and interstices that the ravelling-out of apartheid colonialism produced” (Writing 128), Nadine Gordimer recounts how her artistic calling preceded her political activism. In this essay, entitled “That Other World that Was the World,” she explains that before she committed herself to the anti-apartheid struggle per se, she had mingled with black writers, painters, and actors, an..

Revolution(s)

In 2018, the theme for the annual conference of the SAES (Société des Anglicistes de l’Enseignement Supérieur), held at Nanterre University, itself a site of student revolution in the past, was “Revolution(s),” a notion which has particular resonance for the New Literatures panel which provided the genesis of many of the articles included in this issue. Previously colonised countries, as diverse and geographically disparate as India, South Africa, Nigeria, Canada, and Australia (to name but t..

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The aim of this study was to assess the impact of TNF inhibition on IL-17 production in collagen-induced arthritis, a model of RA. TNF blockade using TNFR-Fc fusion protein or anti-TNF monoclonal antibody reduced arthritis severity but, unexpectedly, expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be pathogenic. Th1 and Th17 cell populations were also expanded in collagen-immunized TNFR p55−/− but not p75−/− mice. The expression of IL-12/IL-23 p40 was up-regulated in lymph nodes (LN) from p55−/− mice, and the expansion of Th1/Th17 cells was abrogated by blockade of p40. Treatment of macrophages with rTNF also inhibited p40 production in vitro. These findings indicate that at least one of the ways in which TNF regulates Th1/Th17 responses in arthritis is by down-regulating the expression of p40. Finally, although TNF blockade increased numbers of Th1 and Th17 cells in LN, it inhibited their accumulation in the joint, thereby providing an explanation for the paradox that anti-TNF therapy ameliorates arthritis despite increasing numbers of pathogenic T cells

Service Provision for Children and Young People with Complex Needs in a Community Setting from The Perspectives of Nursing and Allied Health Professionals - RF 82/2009

EdinburghThis report provides a picture of the key issues facing nurses and allied health professionals in the provision of services for children with complex needs across Scotland. It draws on data from four health board areas and links together information from workforce development plans, a survey practitioners and interviews with practitioners and managers.CIHRpub76