Crop Farmers' Willingness to Use Manure

Replaced with revised version of paper 07/30/04.Crop Production/Industries,

Delayed-Onset Malignant Hyperthermia in Association with Rocuronium Use

Purpose Two cases of malignant hyperthermia suspected to be related to the use of a nondepolarizing neuromuscular blocker are reported. Summary A pharmacogenetic disorder that may occur in as many as 1 in 3000 anesthesia procedures, malignant hyperthermia has been linked to the use of certain anesthetic gases and depolarizing neuromuscular blocking agents (e.g., succinylcholine). Although nondepolarizing neuromuscular blockers were cited as contributing to the development of malignant hyperthermia in a small number of published reports, the agents are generally considered safe for use in at-risk patients. Here investigators report two cases in which the nondepolarizing agent rocuronium is thought to have triggered malignant hyperthermia in patients with no known history of the disorder. In one case, a critically ill 27-year-old man undergoing an induced-hypothermia protocol developed a fever about 4 days after receiving rocuronium infusions, with temperatures rising over 11 days to a maximum of 105.2 °F. In the other case, a 63-year-old man being treated for serious complications of elective surgery developed extreme fever (maximum temperature of 107.1 °F) about 4 days after receiving two bolus doses and a continuous infusion of rocuronium. In both cases, the discontinuation of rocuronium therapy was followed by the rapid diminution of fever over 12–36 hours. After consultations with medical staff and consideration of other potential causal and contributory factors (e.g., neurologic injury, antimicrobial-induced fever), rocuronium was deemed the most likely trigger of the severe febrile response experienced by these two patients. Conclusion A 27-year-old man and a 63-year-old man received rocuronium and subsequently developed delayed-onset malignant hyperthermia, which resolved after the rocuronium was discontinued

Rocky Mountain Trefoil Beef

This fact sheet describes Rocky Mountain trefoil beef and how researchers at USU are exploring the use of tannin-containing legumes as a method fr finishing cattle to address environmental and efficiency concerns associated with the most common current beef production systems

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

SummaryThe transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II. A fraction of P-TEFb is recruited as part of the inhibitory 7SK small nuclear ribonucleoprotein particle (snRNP), which inactivates the kinase and prevents elongation. However, it is unclear how P-TEFb is captured from the promoter-bound 7SK snRNP to activate elongation. Here, we describe a mechanism by which transcription factors mediate the enzymatic release of P-TEFb from the 7SK snRNP at promoters to trigger activation in a gene-specific manner. We demonstrate that Tat recruits PPM1G/PP2Cγ to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop. Similar to Tat, nuclear factor (NF)-κB recruits PPM1G in a stimulus-dependent manner to activate elongation at inflammatory-responsive genes. Recruitment of PPM1G to promoter-assembled 7SK snRNP provides a paradigm for rapid gene activation through transcriptional pause release

Examining the role of integration in marine spatial planning: towards an analytical framework to understand challenges in diverse settings

Marine spatial planning (MSP) as a means of marine governance has been given more prominence recently in response to the problems of fragmentation of marine regulation, environmental protection from increasing pressures upon the seas and the emergence of new maritime industries (Douvere and Ehler, 2009). Therefore enhancing multiple aspects of the way that marine authorities, sectors and stakeholders interact and engage with each other is integral to MSP's role and function and seen as a key means to address fragmented and isolated decision-making in marine space (Portman, 2016). While the function and processes of enhancing integration should not be seen as ends in themselves, they aim to create institutionalised platforms that support multi-level and multi-sectoral governance interaction to achieve 'sustainable use' of marine space (Gilek et al., 2016; Ritchie and Ellis, 2010; Varjopuro et al., 2015). Here, integration mostly plays an instrumental role in realising multiple and divergent political ends (e.g. blue growth, sustainable use, legitimate decision-making) related to ‘integrated spatialized outcomes' that seek to reflect a balance of competing goals (Flannery et al., 2016; Flannery et al., 2018; Jones et al., 2016; Olsen et al., 2014a). Integration is also seen to be important to foster greater connectivity over borders, beneficial for conservation, shipping and fishing (Jay et al., 2016). While claims of the benefits of more integration are intuitively appealing, whether and how these are actually delivered through integration practices remains under-examined in MSP practice; as are empirical insights on the multiplicity of roles that integration plays in MSP. So, while integration has been universally adopted as a policy principle where it is believed that more integration is seen to be closely related to successful planning in numerous ways, there is confusion about what it means, how to do it and what it implies in different MSP contexts. In response, the key aim of this article is to develop an analytical framework useful for examining integration in MSP across a diversity of contexts and processes. Given the central role of integration in MSP, it is vitally important to better understand the linkages between ideas of integration and their practical application in MSP. To examine the role of integration across multiple MSP contexts, we first describe the approach taken in this study. This is followed by a review of relevant MSP and integration related literature to develop an analytical framework. We draw on this framework to illustrate important expressions of integration challenges and responses in our cases. The experiences from the multiple cases are then discussed to generate insights into the various roles that integration plays in MSP and how problems arise and have been addressed. In closing, we underline key findings and reflect on the usefulness and adaptability of the integration approach developed in this article

Rocuronium and Malignant Hyperthermia

Authors response to a comment on: Beggs A, McCann J, Powers J. “Delayed-onset malignant hyperthermia in association with rocuronium use ” Am J Health-Syst Pharm 2012; 69:1128-34