18 research outputs found

    Personal Papers (MS 80-0002)

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    Letter from S. M. McAshan, Jr. to Harris L. Kempner inviting him and Ruth to a dinner he and Susan are hosting

    Design and Measurements of a Deflecting Mode Cavity for an RF Separator

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    The Fermilab Main Injector can produce intense 120 GeV/c proton beams for fixed target experimentation. Two deflecting mode RF systems can be used to separate charged kaons from a momentum selected secondary beam, consisting of pions, kaons and protons, using a time of flight method. We present the RF design of a 3.9 GHz superconducting cavity which operates in the deflecting (TM110) pi-mode and the dependence of the RF parameters on the cavity shape, as determined with finite difference calculations. End cell compensation has been treated, providing cell-to-cell field flatness. First results from measurements on a prototype cavity are shown. We demonstrated that it is possible to tune the deflecting mode of a five cell cavity with bead pull measurements. Effects relating to the polarization of the modes are discussed

    Design and Performance of Cryogenic Enclosures for Long Duration Testing of Large Samples

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    We have designed a large helium dewar as part of an experiment to investigate gravitational radiation. Two such dewars have been constructed. Our use requires a nonmagnetic dewar to cool an aluminium antenna of approximately 5000 kg to below helium temperatures and to keep the antenna in a stable low temperature environment for extended time. This requires a low temperature volume of 1.5 m inner diameter and 3.1 m length and a cooling system capable of efficiently removing the room temperature enthalpy of 8.5 Ă— 108 J. Our solution to this problem is of wider application than simply gravity wave detection so we have discussed the design philosophy in some detail. As constructed, the apparatus uses less than 1 l of helium per hour when cold

    Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits

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    The Enterococcus faecalis pathogenicity island (PAI) encodes known virulence traits and >100 additional genes with unknown roles in enterococcal biology. Phage-related integration and excision genes, and direct repeats flanking the island, suggest it moves as an integrative conjugative element (ICE). However, transfer was observed not to require these genes. Transfer only occurred from donors possessing a pheromone responsive-type of conjugative plasmid, and was invariably accompanied by transfer of flanking donor chromosome sequences. Deletion of plasmid transfer functions, including the cis-acting origin of transfer (oriT), abolished movement. In addition to demonstrating PAI movement by a mechanism involving plasmid integration, we observed transfer of a selectable marker placed virtually anywhere on the chromosome. Transfer of this selectable marker was observed to be accompanied by chromosome-chromosome transfer of vancomycin resistance, MLST markers, and capsule genes as well. Plasmid mobilization therefore appears to be a major mechanism for horizontal gene transfer in the evolution of antibiotic resistant E. faecalis strains capable of causing human infection
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