Letter from Samuel McAdow to James B. Finley

Rev. Samuel J. McAdow sends Finley a detailed description of the last illness and death of his father, Dr. Samuel McAdow (1769??-1844). He died quietly in his 80th year. Samuel asks Finley to write an obituary for the Western Christian Advocate. Abstract Number - 554https://digitalcommons.owu.edu/finley-letters/1850/thumbnail.jp

Letter from James F. McAdow to James B. Finley

James expresses regret (in a teasing way) that Finley has come to so bad an end as to be at the State Penitentiary. McAdow would like Finley to officiate at his wedding in late May. The letter concerns possible arrangements for the ceremony. James asks Finley to keep the wedding a secret. Abstract Number - 1041https://digitalcommons.owu.edu/finley-letters/2025/thumbnail.jp

An Evaluation of Tibia-Level Predictors of Fracture Characteristics in Human Tibiae

Tibia fracture incidence accounts for over 36% of long bone fractures in adults across loading mechanisms. Additionally, the tibia is the most commonly fractured lower extremity bone in pedestrian-motor vehicle impacts. Increased fracture severity, especially in the tibia, causes increases in both the physical and financial burden associated with recovery. Current research encompasses quantification of cross-sectional tibia features, trends of these features across ages and between sexes, and how tibia features are related to fracture risk. Research is lacking, however, in identification of predictors of differences in fracture severity and identification of populations at risk for increased tibia fracture severity. Therefore, the objective of this study was to investigate relationships between individual-level and tibia-level variables with fracture severity, specifically, the number of fractures per tibia. Sixteen human tibiae (8 male, 8 female) were loaded to failure in a 4-point bending scenario at 6 m/s in a lateral-medial direction. Prior to testing, computed tomography (CT) scans of each tibia were obtained and tibia-level variables (cortical area, cortical thickness, percent cortical area, total area, endosteal area, and volumetric bone mineral density) were collected at the 50% site of each tibia. Relationships between individual-level and tibia-level variables and number of fractures per tibia were explored; however, no significant relationships were observed. General trends observed included fewer fracture numbers in females, likely influenced by smaller tibiae and thus smaller ratios of cortical area when compared to male tibiae. Male tibiae facilitated more fractures in this study, as the more robust nature of male tibiae allowed for propagation into multiple fractures when traumatic force was applied. Future research should include a larger sample size, as well as expanded tibia-level and fracture-level variables to further investigate populations at risk for increased fracture severity.No embargoAcademic Major: Anthropological Science

Letter from James F. McAdow and Malinda Kopp to James B. Finley

James F. McAdow and his fiance Malinda Kopp (Ropp, Rupp) reply to Finley\u27s recent letter stating that he cannot officiate at their wedding on May 29th, but is available on May 20th. This doesn\u27t work for James F. because he has school until the 29th. The couple suggests that Finley select any day after the 29th that is convenient for him, and they will be happy. James F. is interested in Finley\u27s work with the prisoners, and would like to visit the prison when he and Malinda come to Columbus for a visit following their wedding. Abstract Number - 1042https://digitalcommons.owu.edu/finley-letters/2026/thumbnail.jp

Penalties Off the Field: Exploring Social Media Policies for Student Athletes at Universities

University student-athletes and their teams rely on social media to communicate with their fans, and these interactions may be beneficial for teams and athletes alike. But social media use also carries risk if an offensive photo or statement goes viral. Using frameworks from social cognitive, privacy, and uses and gratification theories, this article captures the status of university social media policies for athletes through content analysis and interviews. The findings outline strategies for monitoring, penalizing and rewarding athletes for their online interactions

Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila

Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis in Drosophila, also directs cellular morphogenesis after cell cycle exit. In mitotic cells, the Aurora kinases activate Polo to control a cytoskeletal regulatory module that directs cytokinesis. We show that in the post-mitotic mesoderm, the control of Polo activity transitions from the Aurora kinases to the uncharacterized kinase Back Seat Driver (Bsd), where Bsd and Polo cooperate to regulate muscle morphogenesis. Polo and its effectors therefore direct mitosis and cellular morphogenesis, but the transition from growth to morphogenesis is determined by the spatiotemporal expression of upstream activating kinases

Contribution of Coagulases towards <i>Staphylococcus aureus</i> Disease and Protective Immunity

The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules. Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.</p

Preventing <i>Staphylococcus aureus</i> Sepsis through the Inhibition of Its Agglutination in Blood

Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. When suspended in human or animal plasma, staphylococci are known to agglutinate, however the bacterial factors responsible for agglutination and their possible contribution to disease pathogenesis have not yet been revealed. Using a mouse model for S. aureus sepsis, we report here that staphylococcal agglutination in blood was associated with a lethal outcome of this disease. Three secreted products of staphylococci - coagulase (Coa), von Willebrand factor binding protein (vWbp) and clumping factor (ClfA) – were required for agglutination. Coa and vWbp activate prothrombin to cleave fibrinogen, whereas ClfA allowed staphylococci to associate with the resulting fibrin cables. All three virulence genes promoted the formation of thromboembolic lesions in heart tissues. S. aureus agglutination could be disrupted and the lethal outcome of sepsis could be prevented by combining dabigatran-etexilate treatment, which blocked Coa and vWbp activity, with antibodies specific for ClfA. Together these results suggest that the combined administration of direct thrombin inhibitors and ClfA-antibodies that block S. aureus agglutination with fibrin may be useful for the prevention of staphylococcal sepsis in humans.</p