Anharmonic Torsional Stiffness of DNA Revealed under Small External Torques

DNA supercoiling plays an important role in a variety of cellular processes. The torsional stress related with supercoiling may be also involved in gene regulation through the local structure and dynamics of the double helix. To check this possibility steady torsional stress was applied to DNA in the course of all-atom molecular dynamics simulations. It is found that small static untwisting significantly reduces the torsional persistence length ($l_t$) of GC-alternating DNA. For the AT-alternating sequence a smaller effect of the opposite sign is observed. As a result, the measured $l_t$ values are similar under zero stress, but diverge with untwisting. The effect is traced to sequence-specific asymmetry of local torsional fluctuations, and it should be small in long random DNA due to compensation. In contrast, the stiffness of special short sequences can vary significantly, which gives a simple possibility of gene regulation via probabilities of strong fluctuations. These results have important implications for the role of local DNA twisting in complexes with transcription factors.Comment: 8 pages, 5 figures, to appear in Phys. Rev. Let

Are There Topological Black Hole Solitons in String Theory?

We point out that the celebrated Hawking effect of quantum instability of black holes seems to be related to a nonperturbative effect in string theory. Studying quantum dynamics of strings in the gravitational background of black holes we find classical instability due to emission of massless string excitations. The topology of a black hole seems to play a fundamental role in developing the string theory classical instability due to the effect of sigma model instantons. We argue that string theory allows for a qualitative description of black holes with very small masses and it predicts topological solitons with quantized spectrum of masses. These solitons would not decay into string massless excitations but could be pair created and may annihilate also. Semiclassical mass quantization of topological solitons in string theory is based on the argument showing existence of nontrivial zeros of beta function of the renormalization group.Comment: 12 pages, TeX, requires phyzzx.tex, published in Gen. Rel. Grav. 19 (1987) 1173; comment added on December 18, 199

Equilibrium and nonequilibrium thermodynamics of particle-stabilized thin liquid films

Our recent quasi-two-dimensional thermodynamic description of thin-liquid films stabilized by colloidal particles is generalized to describe nonuniform equilibrium states of films in external potentials and nonequilibrium transport processes produced in the film by gradients of thermodynamic forces. Using a Monte--Carlo simulation method, we have determined equilibrium equations of state for a film stabilized by a suspension of hard spheres. Employing a multipolar-expansion method combined with a flow-reflection technique, we have also evaluated the short-time film-viscosity coefficients and collective particle mobility.Comment: 16 pages, 10 figure

A dynamical model for the heavily ram pressure stripped Virgo spiral galaxy NGC 4522

A dynamical model including ram pressure stripping is applied to the strongly HI deficient Virgo spiral galaxy NGC 4522. A carefully chosen model snapshot is compared with existing VLA HI observations. The model successfully reproduces the large-scale gas distribution and the velocity field. However it fails to reproduce the large observed HI linewidths in the extraplanar component, for which we give possible explanations. In a second step, we solve the induction equation on the velocity fields of the dynamical model and calculate the large scale magnetic field. Assuming a Gaussian distribution of relativistic electrons we obtain the distribution of polarized radio continuum emission which is also compared with our VLA observations at 6 cm. The observed maximum of the polarized radio continuum emission is successfully reproduced. Our model suggests that the ram pressure maximum occurred only ~50 Myr ago. Since NGC 4522 is located far away from the cluster center (~1 Mpc) where the intracluster medium density is too low to cause the observed stripping if the intracluster medium is static and smooth, two scenarios are envisaged: (i) the galaxy moves very rapidly within the intracluster medium and is not even bound to the cluster; in this case the galaxy has just passed the region of highest intracluster medium density; (ii) the intracluster medium is not static but moving due to the infall of the M49 group of galaxies. In this case the galaxy has just passed the region of highest intracluster medium velocity. This study shows the strength of combining high resolution HI and polarized radio continuum emission with detailed numerical modeling of the evolution of the gas and the large-scale magnetic field.Comment: 15 pages, 11 figures, accepted for publication in A&