マウス胎仔下顎のメッケル軟骨の発生成長と変性消失における25kDa熱ショック蛋白質の発現局在の変化と他の軟骨との比較

http://www.ncbi.nlm.nih.gov/pubmed/12592567取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1577号, 学位授与年月日 : 平成15年3月25日, 学位授与大学 : 金沢大

The Use of an Intermaxillary Fixation Screw for Mandibular Setback Surgery

金沢大学医学部附属病院歯科口腔外科Purpose: To assess skeletal stability after mandibular setback surgery with and without an intermaxillary fixation (IMF) screw. Patients and Methods: The subjects were 40 patients with mandibular prognathism. The subjects underwent sagittal split ramus osteotomy with titanium plate fixation and were divided into 2 groups, 1 with and 1 without an IMF screw. A lateral cephalogram was done preoperatively, immediately after surgery, and 1 month, 3 months, and 6 months postoperatively. The 2 groups were then compared statistically. Results: In the comparison of the time-course change between the 2 groups with repeated measure analysis of variance, there were significant differences in occlusal plane (between subjects, F = 2.517; df = 4; P = .0437) and convexity (between subjects, F = 4.048; df = 4; P = .0038). However, there was no significant difference in the other measurements. Conclusion: This study suggested that in most measurements, there was no significant difference between 2 groups with and without an IMF screw in time-course skeletal change. However, use of IMF screws was helpful for orthognathic surgery as a rigid anchor of IMF. © 2007 American Association of Oral and Maxillofacial Surgeons

Changes in occlusal force after mandibular ramus osteotomy with and without Le Fort I osteotomy

金沢大学医学部附属病院歯科口腔外科金沢大学大学院医学系研究科がん細胞学The purpose of this study was to evaluate the differences in bite force changes and occlusal contacts after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO) with and without Le Fort I osteotomy. Sixty female patients with diagnosed mandibular prognathism with or without asymmetry were divided into four groups (SSRO, IVRO, SSRO with Le Fort I osteotomy and IVRO with Le Fort I osteotomy). Bite force and occlusal contacts were measured preoperatively and at 1, 3, 6 and 12 months after surgery with pressure-sensitive sheets. The differences among surgical procedures were examined statistically. Maximum bite force and occlusal contacts returned to preoperative levels after between 3 and 6 months. Regarding time-dependent changes in bite force and occlusal contact area, there were no significant differences among the groups. In conclusion, this study suggests that the combination of IVRO or SSRO and Le Fort I osteotomy does not affect postoperative time-dependent changes. © 2006 International Association of Oral and Maxillofacial surgeons

Use of the Sonopet ultrasonic curettage device in intraoral vertical ramus osteotomy

金沢大学医学部附属病院歯科口腔外科This study was designed to evaluate the usefulness of the Sonopet UST-2001 (Miwatec Co., Ltd., Kawasaki, Kanagawa, Japan) ultrasonic curettage device, and to assess the outcome after intraoral vertical ramus osteotomy (IVRO). Thirteen Japanese adults (age range 20-41 years, mean age 29.6 years) presented with jaw deformities diagnosed as mandibular prognathism and asymmetry; they all underwent IVRO of the mandible. This procedure was followed by ultrasonic bone curettage using the Sonopet to make a guiding notch or groove in the lateral cortex of the ramus without damaging the vessels and nerves. After surgery, the osteotomy line was evaluated by three-dimensional computed tomography. In all patients, osteotomy with the Sonopet device was achieved safely, with minimal bleeding and no major complications. The distal segment could be moved into its ideal position and all patients achieved their ideal profiles. Ultrasonic bone curettage is a safe method for making a guiding groove, without damage to surrounding tissue, prior to complete IVRO. © 2007 International Association of Oral and Maxillofacial Surgeons

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

Shimada, M., Goshima, T., Matsuo, H. et al. Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nat Commun 7, 12059 (2016). https://doi.org/10.1038/ncomms1205

Condylar and disc positions after sagittal split ramus osteotomy with and without Le Fort I osteotomy

金沢大学医学部附属病院歯科口腔外科金沢大学大学院医学系研究科がん細胞学Purpose: The purpose of this study is to examine the changes in temporomandibular joint (TMJ) morphology and clinical symptoms after sagittal split ramus osteotomy (SSRO) with and without a Le Fort I osteotomy. Subjects and Methods: Of 45 Japanese patients with mandibular prognathism, 23 underwent SSRO and 22 underwent SSRO in combination with a Le Fort I osteotomy. The TMJ symptoms and joint morphology, including disc tissue, were assessed preoperatively and postoperatively by magnetic resonance imaging (MRI) and axial cephalography. Results: There were significant differences between pre- and postoperative horizontal changes in the condylar long axis on the right side in the group undergoing SSRO (sagittal split ramus osteotomy) alone. However, there were no other significant differences in pre- and postoperative measurements in this group as compared with the group receiving SSRO plus Le Fort I osteotomy, and the preoperative disc position could not be changed in either group. Conclusion: These results suggest that SSRO, either with or without Le Fort I osteotomy, could not change the preoperative disc position or correct anterior disc displacement, although these procedures did improve the symptoms associated with TMJ dysfunction. © 2007 Mosby, Inc. All rights reserved

The Prevention of Periodontal Bone Loss at the Osteotomy Site After Anterior Segmental and Dento-Osseous Osteotomy

金沢大学医学部附属病院歯科口腔外科Purpose: Degeneration of the gingival margin and periodontal bone loss between segments can occur in various segmental osteotomies. However, treatment and management of these problems have not yet been resolved; improvement of the conventional method is necessary. The purpose of this retrospective study is to evaluate the usefulness and advantage of orthodontic devices in osteotomies. Patients and Methods: Forty Japanese adults presented with jaw deformities diagnosed as mandibular prognathism with maxillary protrusion, bimaxillary protrusion, and anterior crowding. Of these 40 patients, 20 (group 1) underwent anterior segmental osteotomy or dento-osseous osteotomy along with our original orthodontic periodontal management. The remaining 20 (group 2) patients underwent conventional procedures. After surgery, pocket depth and periodontal bone loss at the osteotomy site were evaluated. Results: In all cases of patients who underwent our original technique, degeneration of the gingival marginal and periodontal defects at the osteotomy site were not found. The rate of alveolar bone height in group 1 significantly increased and that in group 2 significantly decreased after maxillary osteotomy (P < .05). Conclusion: This technique may prevent periodontal defects from occurring at the interdental osteotomy site. © 2006 American Association of Oral and Maxillofacial Surgeons

Relationship Between the Morphologies of the Masseter Muscle and the Ramus and Occlusal Force in Patients With Mandibular Prognathism

金沢大学医学部附属病院歯科口腔外科Purpose: The purpose of this study was to examine the relationship between the morphologies of the masseter muscle and the ramus and occlusal force in patients with mandibular prognathism. Patients and Methods: The study group consisted of 71 patients with mandibular prognathism. They were divided into 2 groups, consisting of prognathism with or without symmetry, determined by frontal cephalogram analysis. All patients underwent 3-dimensional (3D) computed tomography (CT) and occlusal force was recorded with pressure-sensitive sheets. Results: In the cross-sectional area of masseter muscle, there were no significant differences between the right and left sides in the symmetry and asymmetry groups. In occlusal force, there was no significant difference between the symmetry and asymmetry groups. Occlusal force was not significantly correlated to the cross-sectional area of the ramus, but it was significantly positively correlated to the cross-sectional area of the masseter muscle (P < .05). Conclusion: Occlusal force was associated with the ipsilateral cross-sectional area of masseter muscle in patients with prognathism; however, it was not associated significantly with the degree of mandibular deviation. © 2006 American Association of Oral and Maxillofacial Surgeons

A comparison of postoperative hypoesthesia between two types of sagittal split ramus osteotomy and intraoral vertical ramus osteotomy, using the trigeminal somatosensory-evoked potential method

金沢大学医学部附属病院歯科口腔外科The purpose of this study was to evaluate hypoesthesia of the lower lip using trigeminal somatosensory-evoked potential following 2 types of sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO). There were 30 patients with mandibular prognathism, with and without asymmetry, who were divided into three groups: the Obwegeser method (Ob) group, the Obwegeser-Dal Pont method (ODP) group and the intraoral vertical ramus osteotomy (IVRO) group. The trigeminal somatosensory-evoked potential was recorded in the region of the lower lip and evaluated preoperatively and postoperatively. The average recovery periods from lower lip hypoesthesia in the IVRO and the Ob group were significantly shorter than in the ODP group (P < 0.05). In conclusion, IVRO showed the earliest recovery from hypoesthesia or an absence of hypoesthesia, and lower lip hypoesthesia was less with the Ob method than the ODP method.© 2006 International Association of Oral and Maxillofacial Surgeons

Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population

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