Concert recording 2013-11-26a

[Track 01]. Trio in G minor, op. 63. Allegro moderato ; [Track 02]. Scherzo: Allegro vivace ; [Track 03]. Schafers Klage: Andante espressivo ; Finale: Allegro / C.M. von Weber -- [Track 04]. Marchenerzahlungen op. 132. Lebhaft, nicht zu schnell ; [Track 05]. Lebhaft und sehr markirt ; [Track 06]. Ruhiges tempo, mit zartem Ausdruck ; [Track 07]. Lebhaft, sehr markirt / R. Schumann -- [Track 08]. Clarinet sonata in E-flat major, op. 120, no. 2. Allegro amabile ; [Track 09]. Allegro appassionate ; [Track 10]. Andante con moto / J. Brahms

Concert recording 2013-04-14a

[Track 01]. Moving air / Nigel Westlake -- [Track 02]. New York counterpoint / Steve Reich -- [Track 03]. In motion hand covers bruise / Trent Reznor ; Atticus Ross -- [Track 04]. When it rains / Brad Mehldau -- [Track 05]. Born to be wild / David Lang -- [Track 06]. Cheating, lying, stealing / David Lang -- [Track 07]. Two instrumental rounds in snaketime / Moondog -- [Track 08]. Motown metal / Michael Daughterty

Concert recording 2013-11-23b

[Track 01]. Sonata for oboe and piano. Con moto / Edmund Rubbra -- [Track 02]. Solo de concert, op. 35 / Gabriel Pierne -- [Track 03]. Evocations. Peruvienne / Henri Tomasi -- [Track 04]. Six metamorphoses after Ovid. Pan ; Bacchus / Benjamin Britten -- [Track 05]. Concerto for English horn / Gaetano Donizetti -- [Track 06]. Divertimento. Allegro energico ; Maestoso ; Piacevole / Malcolm Arnold -- [Track 07]. Candombe de la Solapa / Jorge Mockert

Concert recording 2013-11-19

[Track 01]. Western fanfare / Eric Ewazen -- [Track 02]. Little sketches / Ivan Elozovic -- [Track 03]. Preludium / Krysztof Penderecki -- [Track 04]. Abime des oiseaux from Quatour pour la fin du temps / Olivier Messiaen -- [Track 05]. Scherzino / Walter Hartley -- [Track 06]. Quintet for winds, no. 2. II ; [Track 07]. III / David Maslanka -- [Track 08]. String quartet, no. 3. III / Dmitri Shostakovich

Validity, Reliability, and Differential Item Functioning of English and French Versions of the 10-Item Connor-Davidson Resilience Scale in Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study

Objective Some individuals with systemic sclerosis (SSc) report positive mental health, despite severe disease manifestations, which may be associated with resilience, but no resilience measure has been validated in SSc. This study was undertaken to assess the validity, reliability, and differential item functioning (DIF) between English- and French-language versions of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) in SSc. Methods Eligible participants were enrolled in the Scleroderma Patient-centered Intervention Network Cohort and completed the CD-RISC-10 between August 2022 and January 2023. We used confirmatory factor analysis (CFA) to evaluate the CD-RISC-10 factor structure and conducted DIF analysis across languages with Multiple Indicators Multiple Causes models. We tested convergent validity with another measure of resilience and measures of self-esteem and depression and anxiety symptoms. We assessed internal consistency and test–retest reliability using Cronbach\u27s alpha and intraclass correlation coefficient (ICC). Results A total of 962 participants were included in this analysis. CFA supported a single-factor structure (Tucker–Lewis index = 0.99, comparative fit index = 0.99, root mean square error of approximation = 0.08 [90% confidence interval (90% CI) 0.07, 0.09]). We found no meaningful DIF. Internal consistency was high (α = 0.93 [95% CI 0.92, 0.94]), and we found that correlations with other measures of psychological functioning were moderate to large (|r| = 0.57–0.78) and confirmed study hypotheses. The scale showed good 1–2-week test–retest reliability (ICC 0.80 [95% CI 0.75, 0.85]) in a subsample of 230 participants. Conclusion The CD-RISC-10 is a valid and reliable measure of resilience in SSc, with score comparability across English and French versions

Concert recording 2014-03-06

[Track 01]. Canzon septimi toni no. 2 / Giovanni Gabrieli -- [Track 02]. Consort for ten winds. Jeux ; [Track 03]. Aubade ; [Track 04]. Sautereau / Robert Spittal -- [Track 05]. Serenade in D minor. Moderato ; [Track 06]. Andante con moto ; [Track 07]. Finale. Allegro molto / Antonin Dvorak

<i>HLA</i> and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined HLA associations in SSc and its autoantibody subsets in a large, newly recruited African American (AA) cohort and among European Americans (EA). In the AA population, the African ancestry-predominant HLA-DRB1*08:04 and HLA-DRB1*11:02 alleles were associated with overall SSc risk, and the HLA-DRB1*08:04 allele was strongly associated with the severe antifibrillarin (AFA) antibody subset of SSc (odds ratio = 7.4). These African ancestry-predominant alleles may help explain the increased frequency and severity of SSc among the AA population. In the EA population, the HLA-DPB1*13:01 and HLA-DRB1*07:01 alleles were more strongly associated with antitopoisomerase (ATA) and anticentromere antibody-positive subsets of SSc, respectively, than with overall SSc risk, emphasizing the importance of HLA in defining autoantibody subtypes. The association of the HLA-DPB1*13:01 allele with the ATA+ subset of SSc in both AA and EA patients demonstrated a transancestry effect. A direct correlation between SSc prevalence and HLA-DPB1*13:01 allele frequency in multiple populations was observed (r = 0.98, P = 3 × 10−6). Conditional analysis in the autoantibody subsets of SSc revealed several associated amino acid residues, mostly in the peptide-binding groove of the class II HLA molecules. Using HLA &#x3B1; / &#x3B2; allelic heterodimers, we bioinformatically predicted immunodominant peptides of topoisomerase 1, fibrillarin, and centromere protein A and discovered that they are homologous to viral protein sequences from the Mimiviridae and Phycodnaviridae families. Taken together, these data suggest a possible link between HLA alleles, autoantibodies, and environmental triggers in the pathogenesis of SSc

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased transcriptomics shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury. Adoptive transfer of macrophages, from either collagen-tagged zebrafish or adult mouse GFPtpz-collagen donors, enhances scar formation via cell autonomous production of collagen. In zebrafish, the majority of tagged collagen localises proximal to the injury, within the overlying epicardial region, suggesting a possible distinction between macrophage-deposited collagen and that predominantly laid-down by myofibroblasts. Macrophage-specific targeting of col4a3bpa and cognate col4a1 in zebrafish significantly reduces scarring in cryoinjured hosts. Our findings contrast with the current model of scarring, whereby collagen deposition is exclusively attributed to myofibroblasts, and implicate macrophages as direct contributors to fibrosis during heart repair

Subject Benchmark Statement Forensic Science

This document is a QAA Subject Benchmark Statement for Forensic Science that defines what can be expected of a graduate in the subject, in terms of what they might know, do and understand at the end of their studies. Subject Benchmark Statements also describe the nature and characteristics of awards in a particular subject or area. Subject Benchmark Statements are published in QAA's capacity as a membership organisation on behalf of the higher education sector. A summary of the Statement is also available on the QAA website