Dynamics of structural defects and plasticity: models and numerical implementation for dynamical problems

We report the plasticity model with explicit description of kinetics of the material defects (dislocations, grain boundaries). This method becomes especially effective for computation of the dynamical deformation of materials at high strain rates because it allows for a simple accounting of the strain rate effects. The equation system is written out and discussed; its implementation is demonstrated for the problem of the plastic flow localization

Research accomplished at the Knowledge Based Systems Lab: IDEF3, version 1.0

An overview is presented of the foundations and content of the evolving IDEF3 process flow and object state description capture method. This method is currently in beta test. Ongoing efforts in the formulation of formal semantics models for descriptions captured in the outlined form and in the actual application of this method can be expected to cause an evolution in the method language. A language is described for the representation of process and object state centered system description. IDEF3 is a scenario driven process flow modeling methodology created specifically for these types of descriptive activities

On the inspiral of Massive Black Holes in gas-rich galaxy mergers

We present a study on the dynamics of massive BHs in galaxy mergers, obtained from a series of high-resolution N-Body/SPH simulations. The presence of a gaseous component is essential for the rapid formation of an eccentric (Keplerian) BH binary, that resides at the center of a massive (~10^9 Msun) turbulent nuclear disc. Using physically and/or numerically motivated recipes, we follow the accretion history of the BHs during the merger. The mass of the BHs increases as large central inflows of gas occur inside each galaxy, and their mass ratio varies with time. Given the encountered strong degeneracy between numerical resolution and physical assumptions, we suggest here three possible paths followed by the galaxies and the BHs during a merger in order to fulfill the M-sigma relation : Adjustment, Symbiosis, and BH Dominance. In an extremely high resolution run, we resolved the turbulent gas pattern down to parsec scales, and found that BH feedback is expected to be effective near the end of the merger. We then trace the BH binary orbit down to a scale of 0.1 pc modeling the nuclear disc as an equilibrium Mestel disc composed either of gas, gas and stars, or just stars. Under the action of dynamical friction against the rotating gaseous and/or stellar background the orbit circularizes. When this occurs, each BH is endowed with its own small-size (~0.01 pc) accretion disc comprising a few percent of the BH mass. Double AGN activity is expected to occur on an estimated timescale of ~10 Myrs, comparable to the inspiral time. The double nuclear point--like sources that may appear have typical separations of ~10 pc, and are likely to be embedded in the still ongoing starburst.Comment: 10 pages, 5 figures, Proceedings of the Conference "The Multicoloured Landscape of Compact Objects and their Explosive Origins", Cefalu` 200

Regulation of T cell expansion by antigen presentation dynamics

An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology. Recent experiments in mice have demonstrated that the expansion of a specific clone of T cells in response to cognate antigen obeys a striking inverse power law with respect to the initial number of T cells. Here, we show that such a relationship arises naturally from a model in which T cell expansion is limited by decaying levels of presented antigen. The same model also accounts for the observed dependence of T cell expansion on affinity for antigen and on the kinetics of antigen administration. Extending the model to address expansion of multiple T cell clones competing for antigen, we find that higher affinity clones can suppress the proliferation of lower affinity clones, thereby promoting the specificity of the response. Employing the model to derive optimal vaccination protocols, we find that exponentially increasing antigen doses can achieve a nearly optimized response. We thus conclude that the dynamics of presented antigen is a key regulator of both the size and specificity of the adaptive immune response

Multiple H-Rearrangements in 10-Benzylthio-dithranol Radical Cations

10-Alkylthio- and 10-arylthio-derivatives of dithranol (anthralin; 1,8-dihydroxy-9-anthrone) are of interest in search for new anti-psoriatic agents2 , 3 ). By working out ms procedures for unequivocal identification of trace amounts of these compounds4 ) it was established that in case of 10-phenylthio-dithranol putative by-products, especially one giving rise to ions at m/z = 226 (dithranol), are artefacts of thermal reaction in the mass spectrometer1). In the EI-MS of those 10-substituted dithranols containing a S-CH2R chain, however, these ions (m/z = 226) arise from M + * as well. Scope and mechanism of their formation was examined by analyzing compound 1 and its D-labelled derivatives 2 and 3

Birth of massive black hole binaries

If massive black holes (BHs) are ubiquitous in galaxies and galaxies experience multiple mergers during their cosmic assembly, then BH binaries should be common albeit temporary features of most galactic bulges. Observationally, the paucity of active BH pairs points toward binary lifetimes far shorter than the Hubble time, indicating rapid inspiral of the BHs down to the domain where gravitational waves lead to their coalescence. Here, we review a series of studies on the dynamics of massive BHs in gas-rich galaxy mergers that underscore the vital role played by a cool, gaseous component in promoting the rapid formation of the BH binary. The BH binary is found to reside at the center of a massive self-gravitating nuclear disc resulting from the collision of the two gaseous discs present in the mother galaxies. Hardening by gravitational torques against gas in this grand disc is found to continue down to sub-parsec scales. The eccentricity decreases with time to zero and when the binary is circular, accretion sets in around the two BHs. When this occurs, each BH is endowed with it own small-size (< 0.01 pc) accretion disc comprising a few percent of the BH mass. Double AGN activity is expected to occur on an estimated timescale of < 1 Myr. The double nuclear point-like sources that may appear have typical separation of < 10 pc, and are likely to be embedded in the still ongoing starburst. We note that a potential threat of binary stalling, in a gaseous environment, may come from radiation and/or mechanical energy injections by the BHs. Only short-lived or sub-Eddington accretion episodes can guarantee the persistence of a dense cool gas structure around the binary necessary for continuing BH inspiral.Comment: To appear in "2007 STScI Spring Symposium: Black Holes", eds. M. Livio & A. M. Koekemoer, Cambridge University Press, 25 pages, 12 figure