Systems, interactions and macrotheory

A significant proportion of early HCI research was guided by one very clear vision: that the existing theory base in psychology and cognitive science could be developed to yield engineering tools for use in the interdisciplinary context of HCI design. While interface technologies and heuristic methods for behavioral evaluation have rapidly advanced in both capability and breadth of application, progress toward deeper theory has been modest, and some now believe it to be unnecessary. A case is presented for developing new forms of theory, based around generic “systems of interactors.” An overlapping, layered structure of macro- and microtheories could then serve an explanatory role, and could also bind together contributions from the different disciplines. Novel routes to formalizing and applying such theories provide a host of interesting and tractable problems for future basic research in HCI

Quasiparticle transport in the vortex state of YBa_2Cu_3O_6.9

The effect of vortices on quasiparticle transport in cuprate superconductors was investigated by measuring the low temperature thermal conductivity of YBa_2Cu_3O_6.9 in magnetic fields up to 8 T. The residual linear term (as T \to 0) is found to increase with field, directly reflecting the occupation of extended quasiparticle states. A study for different Zn impurity concentrations reveals a good agreement with recent calculations for a d-wave superconductor, thereby shedding light on the nature of scattering by both impurities and vortices. It also provides a quantitative measure of the gap near the nodes.Comment: 4 pages, 2 included eps figures, significant new analysis wrt other experiments, to appear in Phys Rev Lett 29 March 199

Diagnostic accuracy of 3.0-T magnetic resonance T1 and T2 mapping and T2-weighted dark-blood imaging for the infarct-related coronary artery in Non-ST-segment elevation myocardial infarction

Background: Patients with recent non–ST‐segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. Methods and Results: We prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2‐weighted short tau inversion recovery [T2W‐STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non–ST‐segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3.0‐T magnetic resonance imaging within 6.5±3.5 days of invasive management. The infarct‐related territory was identified independently using a combination of angiographic, ECG, and clinical findings. The presence and extent of infarction was assessed with late gadolinium enhancement imaging (gadobutrol, 0.1 mmol/kg). The extent of acutely injured myocardium was independently assessed with native T1, T2, and T2W‐STIR methods. The mean infarct size was 5.9±8.0% of left ventricular mass. The infarct zone T1 and T2 times were 1323±68 and 57±5 ms, respectively. The diagnostic accuracies of T1 and T2 mapping for identification of the infarct‐related artery were similar (P=0.125), and both were superior to T2W‐STIR (P<0.001). The extent of myocardial injury (percentage of left ventricular volume) estimated with T1 (15.8±10.6%) and T2 maps (16.0±11.8%) was similar (P=0.838) and moderately well correlated (r=0.82, P<0.001). Mean extent of acute injury estimated with T2W‐STIR (7.8±11.6%) was lower than that estimated with T1 (P<0.001) or T2 maps (P<0.001). Conclusions: In patients with non–ST‐segment elevation myocardial infarction, T1 and T2 magnetic resonance imaging mapping have higher diagnostic performance than T2W‐STIR for identifying the infarct‐related artery. Compared with conventional STIR, T1 and T2 maps have superior value to inform diagnosis and revascularization planning in non–ST‐segment elevation myocardial infarction. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02073422

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

Functional expression of voltage-gated Na+ channels (VGSCs) has been demonstrated in multiple cancer cell types where channel activity induces invasive activity. The signaling mechanisms by which VGSCs promote oncogenesis remain poorly understood. We explored the signal transduction process critical to VGSC-mediated invasion on the basis of reports linking channel activity to gene expression changes in excitable cells. Coincidentally, many genes transcriptionally regulated by the SCN5A isoform in colon cancer have an over-representation of cis-acting sites for transcription factors phosphorylated by ERK1/2 MAPK. We hypothesized that VGSC activity promotes MAPK activation to induce transcriptional changes in invasion-related genes. Using pharmacological inhibitors/activators and siRNA-mediated gene knockdowns, we correlated channel activity with Rap1-dependent persistent MAPK activation in the SW620 human colon cancer cell line. We further demonstrated that VGSC activity induces downstream changes in invasion-related gene expression via a PKA/ERK/c-JUN/ELK-1/ETS-1 transcriptional pathway. This is the first study illustrating a molecular mechanism linking functional activity of VGSCs to transcriptional activation of invasion-related genes

Low-Energy Quasiparticles in Cuprate Superconductors: A Quantitative Analysis

A residual linear term is observed in the thermal conductivity of optimally-doped Bi-2212 at very low temperatures whose magnitude is in excellent agreement with the value expected from Fermi-liquid theory and the d-wave energy spectrum measured by photoemission spectroscopy, with no adjustable parameters. This solid basis allows us to make a quantitative analysis of thermodynamic properties at low temperature and establish that thermally-excited quasiparticles are a significant, perhaps even the dominant mechanism in suppressing the superfluid density in cuprate superconductors Bi-2212 and YBCO.Comment: Revised version with additional page, figure, table and reference; to appear in Physical Review B (1 August 2000

Quasiparticle-quasiparticle Scattering in High Tc Superconductors

The quasiparticle lifetime and the related transport relaxation times are the fundamental quantities which must be known in order to obtain a description of the transport properties of the high T_c superconductors. Studies of these quantities have been undertaken previously for the d-wave, high T_c superconductors for the case of temperature-independent elastic impurity scattering. However, much less is known about the temperature-dependent inelastic scattering. Here we give a detailed description of the characteristics of the temperature-dependent quasiparticle-quasiparticle scattering in d-wave superconductors, and find that this process gives a natural explanation of the rapid variation with temperature of the electrical transport relaxation rate.Comment: 4 page