Dephasing in disordered systems at low temperatures

The transition from quantum to classical behavior of complex systems, known as dephasing, has fascinated physicists during the last decades. Disordered systems provide an insightful environment to study the dephasing time \tau_\varphi, since electron interference leads to quantum corrections to classical quantities, such as the weak- localization correction \Delta g to the conductance, whose magnitude is governed by \tau_\varphi. In this thesis, we study one of the fundamental questions in this field: How does Pauli blocking influence the interaction-induced dephasing time at low temperatures? In general, Pauli blocking limits the energy transfer \omega of electron interactions to \omega \ll T, which leads to an increase of \tau_\varphi. However, the so-called 0D regime of dephasing, reached at T \ll E_{Th}, is practically the only relevant regime, in which Pauli blocking significantly influences the temperature dependence of \tau_\varphi. Despite of its fundamental physical importance, 0D dephasing has not been observed experimentally in the past. We investigate several possible scenarios for verifying its existence: (1) We analyze the temperature dependence of \Delta g in open and confined systems and give detailed instructions on how the crossover to 0D dephasing can be reliably detected. Two concrete examples are studied: an almost isolated ring and a new quantum dot model. However, we conclude that in transport experiments, 0D dephasing unavoidably occurs in the universal regime, in which all quantum corrections to the conductance depend only weakly on \tau_\varphi, and hence carry only weak signatures of 0D dephasing. (2) We study the quantum corrections to the polarizability \Delta \alpha of isolated systems, and derive their dependence on \tau_\varphi and temperature. We show that \tZeroD dephasing occurs in a temperature range, in which \Delta \alpha depends strongly (as a power-law) on \tau_\varphi, making the quantum corrections to the polarizability an ideal candidate to study dephasing at low temperatures and the influence of Pauli blocking

Case report: Hyperactive delirium after a single dose of zolpidem administered additionally to psychopharmacotherapy including clozapine

The non-benzodiazepine hypnotic zolpidem is frequently administered as a short term psychopharmacotherapy for insomnia. Although it is well-established in a broad clinical routine and often well-tolerated, severe delirium and complex sleep behavior were reported in rare cases. Hereby, it remains unclear whether zolpidem's potential for delirium might be enhanced when combined with further psychopharmacotherapeutics. The present case report portrays a young male Caucasian inpatient with schizoaffective disorder, who was admitted due to severe hyperactive delirium after a single dose of zolpidem 10 mg that was administered in addition to already established psychopharmacotherapy including clozapine 200 mg/day, aripiprazole 15 mg/day and cariprazine 4.5 mg/day. In detail, disorientation, agitation, confabulations, bizarre behavior, and anterograde amnesia occurred shortly after ingestion of zolpidem and gained in intensity within a couple of hours. Once zolpidem was discontinued, the abovementioned symptoms subsided completely and did not reoccur. Since a clear temporal association could be drawn between the intake of zolpidem and the onset of hyperactive delirium, the present clinical experience should serve as a cautionary note for combining potent sedative-hypnotics and substances with anticholinergic properties, even in young adults in a good general condition. Moreover, our case argues for the necessity of further research into the pathomechanism of the interaction potential of non-benzodiazepines as zolpidem, especially with substances exerting anticholinergic properties, which are known for their potential to precipitate delirium. Therefore, the metabolic pathways of the concurrently administered substances should be further taken into account

vorgelegt von

Dephasing in disordered system

Digital Agriculture Infrastructure in the USA and Germany

The USA and Germany have compared the issues that surround the adoption of digital technology on the farm that will foster more environmentally sustainable food production/processing systems. Both countries lack robust broadband internet pathways to foster the adoption of these technologies. The problem is currently relevant to making this data technology available on every farm and field. The implementation of this infrastructure is even more important as society demands more and more information on the product and production process of agriculture and industry

Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing

Purpose!#!To evaluate the diagnostic reliability and practicability of self-collected oropharyngeal swab samples for the detection of SARS-CoV-2 infection as self-sampling could enable broader testing availability and reduce both personal protective equipment and potential exposure.!##!Methods!#!Hospitalized SARS-CoV-2-infected patients were asked to collect two oropharyngeal swabs (SC-OPS1/2), and an additional oropharyngeal swab was collected by a health care professional (HCP-OPS). SARS-CoV-2 PCR testing for samples from 58 participants was performed, with a 48-h delay in half of the self-collected samples (SC-OPS2). The sensitivity, probability of concordance, and interrater reliability were calculated. Univariate and multivariate analyses were performed to assess predictive factors. Practicability was evaluated through a questionnaire.!##!Results!#!The test sensitivity for HCP-OPS, SC-OPS1, and SC-OPS2 was 88%, 78%, and 77%, respectively. Combining both SC-OPS results increased the estimated sensitivity to 88%. The concordance probability between HCP-OPS and SC-OPS1 was 77.6% and 82.5% between SC-OPS1 and SC-OPS2, respectively. Of the participants, 69% affirmed performing future self-sampling at home, and 34% preferred self-sampling over HCP-guided testing. Participants with both positive HCP-OPS1 and SC-OPS1 indicating no challenges during self-sampling had more differences in viral load levels between HCP-OPS1 and SC-OPS1 than those who indicated challenges. Increasing disease duration and the presence of anti-SARS-CoV-2-IgG correlated with negative test results in self-collected samples of previously confirmed SARS-CoV-2 positive individuals.!##!Conclusion!#!Oropharyngeal self-sampling is an applicable testing approach for SARS-CoV-2 diagnostics. Self-sampling tends to be more effective in early versus late infection and symptom onset, and the collection of two distinct samples is recommended to maintain high test sensitivity

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)