2 research outputs found
When the source of false memory helps to differentiate mild cognitive impairment (MCI) from Alzheimer’s Disease (AD)
<p><b>Background</b>.
Episodic memory impairment is at the core of amnestic Mild Cognitive
Impairment (aMCI) and Alzheimer’s Disease (AD). Notably, they both
commit more memory errors than control participants. Nonetheless,
these two groups of patients exhibit the same kinds of memory errors
in recognition. The present study aims at exploring whether the
source of the memory errors might help to distinguish aMCI from AD.</p>
<p><b>Method</b>.
Three groups of participants, 25 healthy elderly adults (HE), 20 aMCI
patients and 9 AD patients, selectively learn 15 words (underlined)
always presented with a distractor (not underlined). Few minutes
after, they complete a yes/no recognition task in which the targets
are mixed with distractors. Half of the distractors comes from the
learning phase (old condition) and the other half are new words (new
condition). Old and new distractors could belong to the same category
(close condition: kettle-coffe maker), or to a related category
(kettle-herbal tea), or to a unrelated category (kettle-spinning top)
as the target.</p>
<p><b>Results</b>.
As expected, HE show the best memory performance followed by the aMCI
patients and finally the AD patients. The same pattern of results is
observed for the memory errors in the new condition. However, aMCI
and AD patients exhibit similar performance in the close condition.
Reversely, the biggest gap in performance between these groups is
reported in the old close distractor condition, whereas similar
performance is shown in the other conditions.</p>
<p><b>Discussion</b>.
The results suggest that both quantity and quality of memories should
be taken into account in the evaluation of memory performance. AD
patients present a more qualitatively impaired memory representation
than aMCI patients (Vallet, Rouleau et al., 2016). This study
highlights the usefulness of a selective learning procedure to
distinguish between aMCI and AD as proposed in the binding memory
test (Buschke, 2014).</p>
<p>
</p
Additional file 3: of SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment
Table S3. Members and affiliations of the Canadian Gait and Cognition Network. (DOCX 16 kb