The V_H repertoire and clonal diversification of B cells in inflammatory myopathies

The contribution of antigen-driven B-cell adaptive immune responses within the inflamed muscle of inflammatory myopathies (IMs) is largely unknown. In this study, we investigated the immunoglobulin VH gene repertoire, somatic hypermutation, clonal diversification, and selection of infiltrating B cells in muscle biopsies from IM patients (dermatomyositis and polymyositis), to determine whether B cells and/or plasma cells contribute to the associated pathologies of these diseases. The data reveal that Ig V<sub>H</sub> gene repertoires of muscle-infiltrating B cells deviate from the normal VH gene repertoire in individual patients, and differ between different types of IMs. Analysis of somatic mutations revealed clonal diversification of muscle-infiltrating B cells and evidence for a chronic B-cell response within the inflamed muscle. We conclude that muscle-infiltrating B cells undergo selection, somatic hypermutation and clonal diversification in situ during antigen-driven immune responses in patients with IMs, providing insight into the contribution of B cells to the pathological mechanisms of these disorders

An icosahedron-based method for pixelizing the celestial sphere

For power spectrum estimation it's important that the pixelization of a CMB sky map be smooth and regular to high degree. With this criterion in mind the ``COBE sky cube" was defined. This paper has as central theme to further improve on this elegant scheme which uses a cube as projective base -- here an icosahedron is used in its place. Although the sky cube is excellent, a further reduction of 20 percent of the number of pixels can be obtained while the pixel distance is maintained, and without any degradation of accuracy for integration. The pixels are rounder in this scheme, where they are hexagonal rather than square, and the faces are small in this implementation which simplifies area-equalization. The reason distortion is lessened is that the faces are smaller and therefore more flat. To use the method, you can get a FORTRAN code from the Internet.Comment: 13 pages, with 3 figures included. Source code and color figures at http://www.sns.ias.edu/~max/icosahedron.html (faster from the US), from http://www.mpa-garching.mpg.de/~max/icosahedron.html (faster from Europe) or from [email protected]

Constraining the limiting brightness temperature and Doppler factors for the largest sample of radio bright blazars

Relativistic effects dominate the emission of blazar jets complicating our understanding of their intrinsic properties. Although many methods have been proposed to account for them, the variability Doppler factor method has been shown to describe the blazar populations best. We use a Bayesian hierarchical code called {\it Magnetron} to model the light curves of 1029 sources observed by the Owens Valley Radio Observatory's 40-m telescope as a series of flares with an exponential rise and decay, and estimate their variability brightness temperature. Our analysis allows us to place the most stringent constraints on the equipartition brightness temperature i.e., the maximum achieved intrinsic brightness temperature in beamed sources which we found to be $\rm \langle T_{eq}\rangle=2.78\times10^{11}K\pm26\%$. Using our findings we estimated the variability Doppler factor for the largest sample of blazars increasing the number of available estimates in the literature by almost an order of magnitude. Our results clearly show that $\gamma$-ray loud sources have faster and higher amplitude flares than $\gamma$-ray quiet sources. As a consequence they show higher variability brightness temperatures and thus are more relativistically beamed, with all of the above suggesting a strong connection between the radio flaring properties of the jet and $\gamma$-ray emission.Comment: 14 pages, 8 figures, accepted for publication in AP

Lyman-alpha absorption around nearby galaxies

We have used STIS aboard HST to search for Lyman-alpha (Lya) absorption lines in the outer regions of eight nearby galaxies using background QSOs and AGN as probes. Lya lines are detected within a few hundred km/s of the systemic velocity of the galaxy in all cases. We conclude that a background line-of-sight which passes within 26-200 h-1 kpc of a foreground galaxy is likely to intercept low column density neutral hydrogen with log N(HI) >~ 13.0. The ubiquity of detections implies a covering factor of ~ 100% for low N(HI) gas around galaxies within 200 h-1 kpc. We discuss the difficulty in trying to associate individual absorption components with the selected galaxies and their neighbors, but show that by degrading our STIS data to lower resolutions, we are able to reproduce the anti-correlation of Lya equivalent width and impact parameter found at higher redshift. We also show that the equivalent width and column density of Lya complexes (when individual components are summed over ~ 1000 km/s) correlate well with a simple estimate of the volume density of galaxies brighter than M(B) = -17.5 at the same redshift as a Lya complex. We do not reject the hypothesis that the selected galaxies are directly responsible for the observed Lya lines, but our analysis indicates that absorption by clumpy intragroup gas is an equally likely explanation. (Abriged)Comment: Accepted for publication in Nov 20, 2002 issue of ApJ. Paper with all figures can be found at http://www.astro.princeton.edu/~dvb/lyapaper.ps (preferable). Minor typos fixe

A new 1.6-micron map of Titan’s surface

We present a new map of Titan's surface obtained in the spectral 'window' at ∼1.6 μm between strong methane absorption. This pre-Cassini view of Titan's surface was created from images obtained using adaptive optics on the W.M. Keck II telescope and is the highest resolution map yet made of Titan's surface. Numerous surface features down to the limits of the spatial resolution (∼200–300 km) are apparent. No features are easily identifiable in terms of their geologic origin, although several are likely craters

The F-GAMMA program: Multi-frequency study of Active Galactic Nuclei in the Fermi era. Program description and the first 2.5 years of monitoring

To fully exploit the scientific potential of the Fermi mission, we initiated the F-GAMMA program. Between 2007 and 2015 it was the prime provider of complementary multi-frequency monitoring in the radio regime. We quantify the radio variability of gamma-ray blazars. We investigate its dependence on source class and examine whether the radio variability is related to the gamma-ray loudness. Finally, we assess the validity of a putative correlation between the two bands. The F-GAMMA monitored monthly a sample of about 60 sources at up to twelve radio frequencies between 2.64 and 228.39 GHz. We perform a time series analysis on the first 2.5-year dataset to obtain variability parameters. A maximum likelihood analysis is used to assess the significance of a correlation between radio and gamma-ray fluxes. We present light curves and spectra (coherent within ten days) obtained with the Effelsberg 100-m and IRAM 30-m telescopes. All sources are variable across all frequency bands with amplitudes increasing with frequency up to rest frame frequencies of around 60 - 80 GHz as expected by shock-in-jet models. Compared to FSRQs, BL Lacs show systematically lower variability amplitudes, brightness temperatures and Doppler factors at lower frequencies, while the difference vanishes towards higher ones. The time scales appear similar for the two classes. The distribution of spectral indices appears flatter or more inverted at higher frequencies for BL Lacs. Evolving synchrotron self-absorbed components can naturally account for the observed spectral variability. We find that the Fermi-detected sources show larger variability amplitudes as well as brightness temperatures and Doppler factors, than non-detected ones. Flux densities at 86.2 and 142.3 GHz correlate with 1 GeV fluxes at a significance level better than 3sigma, implying that gamma rays are produced very close to the mm-band emission region.Comment: Accepted for publication in section 4. Extragalactic astronomy of Astronomy and Astrophysics (18 pages, 9 figures

A new regime of anomalous penetration of relativistically strong laser radiation into an overdense plasma

It is shown that penetration of relativistically intense laser light into an overdense plasma, accessible by self-induced transparency, occurs over a finite length only. The penetration length depends crucially on the overdense plasma parameter and increases with increasing incident intensity after exceeding the threshold for self-induced transparency. Exact analytical solutions describing the plasma-field distributions are presented.Comment: 6 pages, 2 figures in 2 separate eps files; submitted to JETP Letter

J.S. Bell's Concept of Local Causality

John Stewart Bell's famous 1964 theorem is widely regarded as one of the most important developments in the foundations of physics. It has even been described as "the most profound discovery of science." Yet even as we approach the 50th anniversary of Bell's discovery, its meaning and implications remain controversial. Many textbooks and commentators report that Bell's theorem refutes the possibility (suggested especially by Einstein, Podolsky, and Rosen in 1935) of supplementing ordinary quantum theory with additional ("hidden") variables that might restore determinism and/or some notion of an observer-independent reality. On this view, Bell's theorem supports the orthodox Copenhagen interpretation. Bell's own view of his theorem, however, was quite different. He instead took the theorem as establishing an "essential conflict" between the now well-tested empirical predictions of quantum theory and relativistic \emph{local causality}. The goal of the present paper is, in general, to make Bell's own views more widely known and, in particular, to explain in detail Bell's little-known mathematical formulation of the concept of relativistic local causality on which his theorem rests. We thus collect and organize many of Bell's crucial statements on these topics, which are scattered throughout his writings, into a self-contained, pedagogical discussion including elaborations of the concepts "beable", "completeness", and "causality" which figure in the formulation. We also show how local causality (as formulated by Bell) can be used to derive an empirically testable Bell-type inequality, and how it can be used to recapitulate the EPR argument.Comment: 19 pages, 4 figure