1 research outputs found
Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation,
copper homeostasis and metformin side effects. However, each factor was analyzed
separately, and only in some rare cases copper/amylin or copper/metformin complexes were
considered. We demonstrate for the first time that binary metformin/amylin and tertiary copper
(II)/amylin/metformin complexes of high cellular toxicity are formed and lead to the formation
of aggregated multi-level lamellar structures on the cell membrane. Considering the increased
concentration of amylin, copper (II) and metformin in kidneys of T2DM patients, our findings on the
toxicity of amylin and its adducts may be correlated with diabetic nephropathy development