Cyclosporin neurotoxicity in cardiac transplant recipient.

Letterinfo:eu-repo/semantics/publishe

Discovering market trends in the biotechnology industry

In this paper we describe our approach to discover trends for the biotechnology and pharmaceutical industry based on temporal text mining. Temporal text mining combines information extraction and data mining techniques upon textual repositories and our main objective is to identify changes of associations among entities of interest over time. It consists of three main phases; the Information Extraction, the ontology driven generalisation of templates and the discovery of associations over time. Treatment of the temporal dimension is essential to our approach since it influences both the annotation part (IE) of the system as well as the mining part. Copyright © 2011 Inderscience Enterprises Ltd

Devic's neuromyelitis optica and Schilder's myelinoclastic diffuse sclerosis.

CommentLetterSCOPUS: le.jinfo:eu-repo/semantics/publishe

The characteristics of patients with bilateral absent evoked potentials after post-anoxic brain damage: A multicentric cohort study.

Patients with bilateral absence of cortical response (N20 <sub>ABS</sub> ) to somatosensory evoked potentials (SSEPs) have poor neurological outcome after cardiac arrest (CA). However, SSEPs are not available in all centers. The aim of this study was to identify predictors of N20 <sub>ABS</sub> . Retrospective analysis of institutional databases (2008-2015) in three ICUs including all adult admitted comatose patients undergoing SSEPs between 48 and 72 h after CA. We collected clinical (i.e. absence of pupillary reflexes, PLR, myoclonus and absent or posturing motor response and myoclonus on day 2-3), electroencephalographic (EEG; i.e. unreactive to painful stimuli; presence of a highly malignant patterns, such as burst-suppression or flat tracings) findings during the first 48 h, and the highest NSE levels on the first 3 days after CA. Unfavorable neurological outcome (UO) was assessed at 3 months using the Cerebral Performance Categories of 3-5. We studied 532 patients with SSEPs, including 143 (27%) without N20 <sub>ABS</sub> ; UO was observed in 334 (63%) patients. Median time to SSEPs was 72 [48-72] h after CA. No patient with absent PLR and myoclonus during the ICU stay had N20 present; similar results were observed with the combination of absent PLR, myoclonus and any EEG pattern (i.e. unreactive or highly malignant). Similar results were observed in the subgroup of patients where NSE was available (n = 303). In a multivariate logistic regression, non-cardiac etiology of arrest, unreactive EEG to painful stimuli, absence of pupillary reflexes and posturing motor response, were independent predictors of N20 <sub>ABS</sub> . When available, the highest NSE was also an independent predictor of N20 <sub>ABS</sub> . Clinical and EEG findings predicting patients with N20 <sub>ABS</sub> , confirm that N20 <sub>ABS</sub> reflects a severe and permanent cerebral damage after CA