55 research outputs found
Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems
Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states.
Methods: CORE-OM is a 34-item instrument monitoring clinical outcomes of people with common mental health problems. CORE-OM is characterised by high correlation across its domains. Rasch analysis was used to reduce the number of items and response levels in order to produce a set of unidimensionally-behaving items, and to generate a credible set of health states corresponding to different levels of symptom severity using the Rasch item threshold map.
Results: The proposed methodology resulted in the development of CORE-6D, a 2-dimensional health state description system consisting of a unidimensionally-behaving 5-item emotional component and a physical symptom item. Inspection of the Rasch item threshold map of the emotional component helped identify a set of 11 plausible health states, which, combined with the physical symptom item levels, will be used for the valuation of the instrument, resulting in the development of a preference-based index.
Conclusions: This is a useful new approach to develop preference-based measures where the domains of a measure are characterised by high correlation. The CORE-6D preference-based index will enable calculation of Quality Adjusted Life Years in people with common mental health problems
Estimating a preference-based index from the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM): valuation of CORE-6D
Background: The Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) is used to evaluate the effectiveness of psychological therapies in people with common mental disorders. The objective of this study was to estimate a preference-based index for this population using CORE-6D, a health state classification system derived from CORE-OM consisting of a 5-item emotional component and a physical item, and to demonstrate a novel method for generating states that are not orthogonal.
Methods: Rasch analysis was used to identify 11 plausible âemotionalâ health states from CORE-6D (rather than conventional statistical design that would generate implausible states). By combining these with the 3 response levels of the physical item of CORE-6D, 33 plausible health states can be described, of which 18 were selected for valuation. An interview valuation survey of 220 members of public in South Yorkshire, UK, was undertaken using the time-trade-off method to value the 18 health states; regression analysis was subsequently used to predict values for all possible states described by CORE-6D.
Results: A number of multivariate regression models were built to predict values for the 33 plausible health states of CORE-6D, using the Rasch logit value of the emotional health state and the response level of the physical item as independent variables. A cubic model with high predictive value (adjusted R squared 0.990) was finally selected, which can be used to predict utility values for all 927 states described by CORE-6D.
Conclusion: The CORE-6D preference-based index will enable the assessment of cost-effectiveness of interventions for people with common mental disorders using existing and prospective CORE-OM datasets. The new method for generating states may be useful for other instruments with highly correlated dimensions
Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems
Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states. Methods: CORE-OM is a 34-item instrument monitoring clinical outcomes of people with common mental health problems. CORE-OM is characterised by high correlation across its domains. Rasch analysis was used to reduce the number of items and response levels in order to produce a set of unidimensionally-behaving items, and to generate a credible set of health states corresponding to different levels of symptom severity using the Rasch item threshold map. Results: The proposed methodology resulted in the development of CORE-6D, a 2-dimensional health state description system consisting of a unidimensionally-behaving 5-item emotional component and a physical symptom item. Inspection of the Rasch item threshold map of the emotional component helped identify a set of 11 plausible health states, which, combined with the physical symptom item levels, will be used for the valuation of the instrument, resulting in the development of a preference-based index. Conclusions: This is a useful new approach to develop preference-based measures where the domains of a measure are characterised by high correlation. The CORE-6D preference-based index will enable calculation of quality adjusted life years in people with common mental health problems.Rasch analysis; health-related quality of life; condition-specific measure; preference-based health; health states; CORE-6D; CORE-OM; mental health; quality-adjusted life years
Estimating a preference-based index from the clinical outcomes in routine evaluation-outcome measure (CORE-OM): Valuation of CORE-6D
Background. The Clinical Outcomes in Routine EvaluationâOutcome Measure (CORE-OM) is used to evaluate the effectiveness of psychological therapies in people with common mental disorders. The objective of this study was to estimate a preference-based index for this population using CORE-6D, a health state classification system derived from the CORE-OM consisting of a 5-item emotional component and a physical item, and to demonstrate a novel method for generating states that are not orthogonal. Methods. Rasch analysis was used to identify 11 emotional health states from CORE-6D that were frequently observed in the study population and are, thus, plausible (in contrast, conventional statistical design might generate implausible states). Combined with the 3 response levels of the physical item of CORE-6D, they generate 33 plausible health states, 18 of which were selected for valuation. A valuation survey of 220 members of the public in South Yorkshire, United Kingdom, was undertaken using the time tradeoff (TTO) method. Regression analysis was subsequently used to predict values for all possible states described by CORE-6D. Results. A number of multivariate regression models were built to predict values for the 33 health states of CORE-6D, using the Rasch logit value of the emotional state and the response level of the physical item as independent variables. A cubic model with high predictive value (adjusted R2 = 0.990) was selected to predict TTO values for all 729 CORE-6D health states. Conclusion. The CORE-6D preference-based index will enable the assessment of cost-effectiveness of interventions for people with common mental disorders using existing and prospective CORE-OM data sets. The new method for generating states may be useful for other instruments with highly correlated dimensions
Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems
Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states.
Methods: CORE-OM is a 34-item instrument monitoring clinical outcomes of people with common mental health problems. CORE-OM is characterised by high correlation across its domains. Rasch analysis was used to reduce the number of items and response levels in order to produce a set of unidimensionally-behaving items, and to generate a credible set of health states corresponding to different levels of symptom severity using the Rasch item threshold map.
Results: The proposed methodology resulted in the development of CORE-6D, a 2-dimensional health state description system consisting of a unidimensionally-behaving 5-item emotional component and a physical symptom item. Inspection of the Rasch item threshold map of the emotional component helped identify a set of 11 plausible health states, which, combined with the physical symptom item levels, will be used for the valuation of the instrument, resulting in the development of a preference-based index.
Conclusions: This is a useful new approach to develop preference-based measures where the domains of a measure are characterised by high correlation. The CORE-6D preference-based index will enable calculation of quality adjusted life years in people with common mental health problems
Cost-effectiveness of psychological interventions for children and young people with post-traumatic stress disorder
Background: PTSD in youth may lead to longâlasting psychological implications, educational difficulties and increased healthcare costs. Psychological interventions have been shown to be effective in its management. The objective of this study was to assess the costâeffectiveness of a range of psychological interventions for children and young people with PTSD. /
Methods: A decisionâanalytic model was constructed to compare costs and qualityâadjusted life years (QALYs) of 10 psychological interventions and no treatment for children and young people with PTSD, from the perspective of the National Health Service and personal social services in England. Effectiveness data were derived from a systematic review and network metaâanalysis. Other model input parameters were based on published sources, supplemented by expert opinion. /
Results: Cognitive therapy for PTSD, a form of individual traumaâfocused cognitive behavioural therapy (TFâCBT), appeared to be the most costâeffective intervention for children and young people with PTSD (with a probability of .78 amongst the 11 evaluated options at a costâeffectiveness threshold of ÂŁ20,000/QALY), followed by narrative exposure (another form of individual TFâCBT), play therapy, and other forms of individual TFâCBT. After excluding cognitive therapy from the analysis, narrative exposure appeared to be the most costâeffective option with a .40 probability of being costâeffective amongst the remaining 10 options. EMDR, parent training and group TFâCBT occupied middle costâeffectiveness rankings. Family therapy and supportive counselling were less costâeffective than other active interventions. There was limited evidence for some interventions, in particular cognitive therapy for PTSD and parent training. /
Conclusions: Individual forms of TFâCBT and, to a lesser degree, play therapy appear to be costâeffective in the treatment of children and young people with PTSD. Family therapy and supportive counselling are unlikely to be costâeffective relative to other interventions. There is a need for wellâconducted studies that examine the longâterm clinical and costâeffectiveness of a range of psychological treatments for children and young people with PTSD
The cost-effectiveness of antenatal and postnatal education and support interventions for women aimed at promoting breastfeeding in the UK
Background:
Breastfeeding is associated with health benefits to mothers and babies and cost-savings to the health service. Breastfeeding rates in the UK are low for various reasons including cultural barriers, inadequate support to initiate and sustain breastfeeding, lack of information, or choice not to breastfeed. Education and support interventions have been developed aiming at promoting breastfeeding rates. The objective of this study was to assess the cost-effectiveness of such interventions for women, initiated antenatally or in the first 8âweeks postnatally, aiming at improving breastfeeding rates, in the UK.
Methods:
A decision-analytic model was constructed to compare costs and quality-adjusted life-years (QALYs) of a breastfeeding intervention from the perspective of health and personal social services in England. Data on intervention effectiveness and the benefits of breastfeeding were derived from systematic reviews. Other model input parameters were obtained from published sources, supplemented by expert opinion.
Results:
The incremental cost-effectiveness ratio (ICER) of the modelled intervention added on standard care versus standard care was ÂŁ51,946/QALY, suggesting that the intervention is not cost-effective under National Institute for Health and Care Excellence (NICE) criteria in England. Sensitivity analysis suggested that the cost-effectiveness of the intervention improved as its effectiveness increased and intervention cost decreased. At the base-case effect (increase in breastfeeding rates 16â26âweeks after birth by 19%), the intervention was cost-effective (<ÂŁ20,000/QALY) if its cost per woman receiving the intervention became âÂŁ40âÂŁ45. At the base-case cost (ÂŁ84), the intervention was cost-effective if it increased breastfeeding rates by at least 35â40%.
Conclusions:
Available breastfeeding interventions do not appear to be cost-effective under NICE criteria in England. Future breastfeeding interventions need to have higher effectiveness or lower cost compared with currently available interventions in order to become cost-effective. Public health and other societal interventions that protect, promote and support breastfeeding may be key in improving breastfeeding rates in the UK
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Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance
Social anxiety disorder is one of the most persistent and common of the anxiety disorders, with lifetime prevalence rates in Europe of 6.7% (range 3.9-13.7%).1 It often coexists with depression, substance use disorder, generalised anxiety disorder, panic disorder, and post-traumatic stress disorder.2 It can severely impair a personâs daily functioning by impeding the formation of relationships, reducing quality of life, and negatively affecting performance at work or school. Despite this, and the fact that effective treatments exist, only about half of people with this condition seek treatment, many after waiting 10-15 years.3 Although about 40% of those who develop the condition in childhood or adolescence recover before adulthood,4 for many the disorder persists into adulthood, with the chance of spontaneous recovery then limited compared with other mental health problems.
This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) on recognising, assessing, and treating social anxiety disorder in children, young people, and adults.
Guidelines: Recognition, assessment and treatment of social anxiety disorder: Summary of NICE guidance
Social anxiety disorder is one of the most persistent and common of the anxiety disorders, with lifetime prevalence rates in Europe of 6.7% (range 3.9-13.7%). It often coexists with depression, substance use disorder, generalised anxiety disorder, panic disorder, and post-traumatic stress disorder. It can severely impair a personâs daily functioning by impeding the formation of relationships, reducing quality of life, and negatively affecting performance at work or school. Despite this, and the fact that effective treatments exist, only about half of people with this condition seek treatment, many after waiting 10-15 years. Although about 40% of those who develop the condition in childhood or adolescence recover before adulthood, for many the disorder persists into adulthood, with the chance of spontaneous recovery then limited compared with other mental health problems
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