A study of incidence and pattern of coronary artery anomalies in Western Rajasthan, India

Background: Coronary artery anomalies (CAAs) are a diverse group of congenital disorders whose manifestations and pathophysiological mechanisms are highly variable. Among patients undergoing coronary angiography, the incidence depends on the population studied and the criteria used to define an anomaly. This is the first ever study conducted in western Rajasthan to detect the incidence and pattern of coronary anomalies.Methods: We retrospectively studied 8500 coronary angiographies (CAG) done in the institution over a period of 12 years from 2004 to 2015 for detection of incidence and pattern of coronary anomalies. Patients with ischemic heart disease and valvular heart disease who underwent CAG were included in the study.Results: Out of the 8500 angiograms screened a total of 108 coronary anomalies were detected (incidence of 1.27%). Anomalies of origin and course was the most common anomaly (106 out of 108 patients) followed by anomalies of  coronary termination (fistulas) which was seen in just two patients. Most common anomaly was absent left main artery with separate origin of the left anterior descending (LAD) artery and left circumflex artery (LCx) (n=36, 33.3%), followed closely by anomalous origin of right coronary artery (RCA) from left sinus (n=34, 31.48%). Anomalous origin of LCx from right sinus/ RCA was the third most common anomaly (n=22, 20.37%). Other rare anomalies include anomalous origin of left coronary artery from right coronary sinus (n=6, 5.55%), RCA from posterior sinus (n=4, 3.7%). Single coronary artery, LAD from RCA and coronary artery fistula were seen in two patients each (n=2, 1.85%).Conclusions: In present study though the total incidence of coronary anomalies was similar to that in other studies, the pattern of coronary anomalies was slightly different from that reported from different parts of the world.

Filgrastim as a Rescue Therapy for Persistent Neutropenia in a Case of Dengue Hemorrhagic Fever with Acute Respiratory Distress Syndrome and Myocarditis

Pathogenesis of dengue involves suppression of immune system leading to development of characteristic presentation of haematological picture of thrombocytopenia and leucopenia. Sometimes, this suppression in immune response is responsible for deterioration in clinical status of the patient in spite of all specific and supportive therapy. Certain drugs like steroids are used for rescue therapy in conditions like sepsis. We present a novel use of filgrastim as a rescue therapy in a patient with dengue hemorrhagic fever (DHF) with acute respiratory distress syndrome (ARDS), myocarditis, and febrile neutropenia and not responding to standard management

Coronary angiographic profile characteristics in young patients with acute coronary syndrome and comparison with older patients with acute coronary syndrome

Background: CAD is a major cause of death worldwide. Indians are prone as a community to CAD at much younger age. This study examined the coronary angiographic profile characteristic in young (60 year).Methods: 192 patients with ACS aged less than 40 year and 200 patients with ACS aged more than 60 year were included in this study. Coronary angiographic profile characteristics were evaluated in young ACS patients and compared with that in older patients.Results: Young ACS patients often had angiographically normal coronary arteries, nonobstructive disease and single vessel disease than older patients (p value<0.05).Conclusions: Angiographically normal coronary arteries, nonobstructive disease, single vessel disease are more frequent in younger patients

Variable fractional power‐least mean square based control algorithm with optimized PI gains for the operation of dynamic voltage restorer

Abstract The operation of Dynamic Voltage Restorer has been studied for the mitigation of supply voltage disturbances like sag, swell, distortions, and unbalances. A Dynamic Voltage Restorer with three single‐phase Voltage Source Converters has been implemented for this purpose. Dynamic Voltage Restorer's compensation capability has been evaluated while introducing the above‐said voltage related disturbances in the supply by different means. A control algorithm named Variable Fractional Power‐Least Mean Square has been proposed for generating the load reference voltage for Dynamic Voltage Restorer. Variable Fractional Power‐Least Mean Square extracts the fundamental active and reactive component out of non‐ideal supply voltage and is thus, used in generating reference load voltage. This algorithm is more robust with respect to disturbance due to variable step size and is computationally less expensive. In addition, an optimization‐based approach has been proposed to estimate the approximate values of PI control gains. For this reason, a population‐based optimization method known as Sine Cosine Optimization has been used. The added feature of the optimization method is the reduction of computational time as compared to conventional PI controller tuning. A model of Dynamic Voltage Restorer using Variable Fractional Power‐Least Mean Square control algorithm with Sine Cosine Optimization tuned PI gains has been built in MATLAB Simulink as well as a reduced scale experimental prototype and their results have been presented with discussion

ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC POTENTIAL OF IPOMOEA BATATAS LEAVES IN VALIDATED DIABETIC ANIMAL MODELS

Objective: The present study was undertaken to investigate the antidiabetic potential of the leaves of Ipomoea batatas.Methods: The crude powder, 95% ethanolic, 50% ethanolic and aqueous extracts of Ipomoea batatas leaves were administered to normoglycemic and streptozotocin (STZ)-induced diabetic rats in a single dose study. The chloroform, butanol and aqueous fractions of aqueous extract were investigated for their antihyperglycemic on STZ-induced diabetic rats. Multiple dose study of an aqueous fraction was also done in STZ and neonatal STZ-induced diabetic rats. Further, the aqueous fraction was measured against the alpha glucosidase and aldose reductase enzymes, and glucose uptake in L6 myotubes.Results: The aqueous extract showed significant lowering of postprandial hyperglycemia of post sucrose loaded normal rats and significantly declined the blood glucose level of STZ-induced diabetic rats. The aqueous fraction at a single dose of 100 mg/kg b. w in comparison with chloroform and butanol fractions significantly lowered the blood glucose level of STZ-induced diabetic rats. The aqueous fraction in a multiple dose study were found to significantly improved the percent glycated hemoglobin (%HbA1c), fasting blood glucose, oral glucose tolerance (OGTT), serum insulin, lipid profile, liver and kidney parameters in STZ-induced diabetic rats. Marked improvement in OGTT and serum insulin levels was also found in neonatal STZ-induced diabetic rats. In vitro study, the aqueous fraction of I. batatas increased glucose uptake in L6 myotubes and inhibits the α-glucosidase and aldose reductase enzymes.Conclusion: The present study demonstrated the significant antidiabetic activity of the I. batatas leaves by promoting insulin secretion, alpha glucosidase and aldose reductase enzyme inhibition.Â

PERFORMANCE OF VARIOUS RICE (Oryza sativa L.) VARIETIES UNDER VARIABLE NITROGEN LEVELS IN THE EASTERN UTTAR PRADESH

A field experiment was conducted at the Indo Gangetic plain of Varanasi in 2017 during the rainy season. The study was conducted in a split-plot design with three main plots treatments viz. three rice varieties (V1- BPT-5204, V2- Rajendra Kasturi and V3- HUBR 2-1) and four subplots treatments viz. nitrogen levels (N1- 100, N2- 120, N3- 140 and N4- 160 kg ha-1). Each treatment was replicated three times. The results of the study revealed that the BPT-5204 variety had significantly higher growth attributes as compared to the other two varieties, including plant height (104.92 cm), leaf area index (5.26),&nbsp; tiller hill-1 (8.25), and dry matter production &nbsp;(46.59 g hill-1), similarly yield and yield parameters were highest in BPT- 5204 rice variety viz. the number of panicles m-2 (352.50), grains panicle-1 (177.08), panicles weight (3.51g), panicle length (23.67 cm), grain yield (50.73q ha-1), biological yield (112.90 q ha-1) and harvest index (0.45) but HUBR 2-1 variety gave significantly higher straw yields (62.17q ha-1) and test weight (20.91 g). For the subplots treatments, nitrogen (N) level 160 kg ha-1 gave the significantly highest growth parameters, yield and yield parameters

EFFECT OF NITROGEN LEVELS ON GROWTH ATTRIBUTES, YIELD AND NUTRIENT UPTAKE OF DIFFERENT RICE (Oryza sativa L.) VARIETIES UNDER THE TRANSPLANTED CONDITION

Rice is very responsive to nitrogen fertilization under transplanted conditions; however N use efficiency and uptake by different varieties may vary. A field study was conducted during the rainy season of 2017 to assess the effect of four nitrogen levels in three rice varieties under the transplanted condition at Agricultural Research Farm, Banaras Hindu University, Varanasi, Uttar Pradesh. The experiment was carried out in a split-plot design (SPD) with three replications. The total number of treatments was twelve involving three rice varieties (V1- BPT-5204, V2- Rajendra Kasturi and V3- HUBR 2-1) in main plots and four nitrogen levels (N1- 100, N2- 120, N3- 140, and N4- 160 kg ha-1) in sub-plots. Rice variety BPT- 5204&nbsp; recorded significantly higher growth parameters viz. leaf number hill-1(37.17), SPAD value (chlorophyll content 31.83), the higher number of days taken to 50 percent flowering (103 days), maturity (130.17 days), grain yield (50.73 q ha-1), biological yield (112.90 q ha-1) and harvest index (0.45) as well as NPK uptakes by grain (60.96, 13.01 &amp; 10.95 kg ha-1) and straw (29.72, 7.15 &amp; 101.55 kg ha-1) as compared to other varieties. However, straw yield (62.17 q ha-1) was reported higher under HUBR 2-1 as compared to the rest varieties. Among the nitrogen levels, N4-160 kg N ha-1 was recorded significantly higher above the same parameter as compared to other nitrogen levels. Hence, the application of N @ 160 kg ha-1 along with rice variety BPT- 5204 can be recommended for achieving higher rice yield, nutrient uptake, and efficiency in Eastern Uttar Pradesh

Predictors of burnout for immigrant mental health professionals in the United States

Mental health professionals who identify as immigrants encounter personal and professional barriers that can impact overall wellbeing. The current study conducted a survey of 108 licensed mental health professionals who identify as immigrants practicing in the United States. The survey included demographics as well as assessments of burnout, social support, and migratory grief and loss. The results of this study highlighted that a combination of higher migratory grief and lower perceived social support significantly predicted higher levels of burnout in mental health professionals. Implications for mental health programs, supervisors, and mentors and suggestions for future research are provided