1 research outputs found
The Impact of Sugars on Kidney Stone Formation
Various studies have found a trend connecting diabetes
mellitus
or carbohydrate malabsorption syndromes to kidney stone formation.
However, the underlying mechanism causing this impact is unclear.
This study aimed to investigate whether some of this correlation is
due to the underlying chemistry of sugars as crystal growth modifiers.
Thus, the impact of major dietary monosaccharides (glucose, fructose,
and galactose) and disaccharides (lactose and sucrose) on the formation
of calcium oxalate was investigated from a crystallization perspective.
The nucleation rate of calcium oxalate generally showed a promotion
when monosaccharides were present. An analysis of the crystals with
Raman spectroscopy found that signals for the monosaccharides are
present within the crystal, showing an association between the sugars
and calcium oxalate. When lactose was present, there was an obvious
promotion of nucleation. When sucrose was present, an interaction
with both the crystal and the solution ions was observed. The presence
of galactose had the most influence on the zeta potential of calcium
oxalate when zinc ions were present, resulting in the smallest zeta
potential value. These results suggest that the sugars in urine may
promote calcium oxalate formation and agglomeration, and this may
suggest a chemical connection to the higher prevalence of stones in
diabetic patients