8 research outputs found
Comparison of the performance of Skin Prick, ImmunoCAP, and ISAC tests in the diagnosis of patients with allergy
Background: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively. The immuno-solid phase allergen chip (ISAC) enables testing for specific IgE against multiple allergen components in a multiplex assay. Methods: We retrospectively analysed clinic letters, case notes, and laboratory results of 118 patients attending the National Adult Allergy Service at the University Hospital of Wales who presented diagnostic difficulty, to evaluate which testing strategy (SPT, ImmunoCAP, or ISAC) was the most appropriate to use to confirm the diagnosis in these complex patients, evaluated in a āreal-lifeā clinical service setting. Results: In patients with nut allergy, the detection rates of SPTs (56%) and ISAC (65%) were lower than those of ImmunoCAP (71%). ISAC had a higher detection rate (88%) than ImmunoCAP (69%) or SPT (33%) in the diagnosis of oral allergy syndrome. ImmunoCAP test results identified all 9 patients with anaphylaxis due to wheat allergy (100%), whereas ISAC was positive in only 6 of these 9 (67%). Conclusions: In this difficult diagnostic group, the ImmunoCAP test should be the preferred single test for possible allergy to nuts, wheat, other specific foods, and anaphylaxis of any cause. In these conditions, SPT and ISAC tests give comparable results. The most useful single test for oral allergy syndrome is ISAC, and SPT should be the preferred test for latex allergy
Stimuli Responsive Hybrid Magnets: Tuning the Photoinduced Spin-Crossover in Fe(III) Complexes Inserted into Layered Magnets
The
insertion of a [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complex
cation into a 2D oxalate network in the presence of different solvents
results in a family of hybrid magnets with coexistence of magnetic
ordering and photoinduced spin-crossover (LIESST effect) in compounds
[Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHCl<sub>3</sub> (<b>1Ā·CHCl</b><sub><b>3</b></sub>), [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHBr<sub>3</sub> (<b>1Ā·CHBr</b><sub><b>3</b></sub>), and [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Br<sub>2</sub> (<b>1Ā·CH</b><sub><b>2</b></sub><b>Br</b><sub><b>2</b></sub>). The three compounds crystallize in a 2D honeycomb anionic layer
formed by Mn<sup>II</sup> and Cr<sup>III</sup> ions linked through
oxalate ligands and a layer of [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes and solvent molecules (CHCl<sub>3</sub>, CHBr<sub>3</sub>, or CH<sub>2</sub>Br<sub>2</sub>) intercalated between the 2D oxalate
network. The magnetic properties and MoĢssbauer spectroscopy
indicate that they undergo long-range ferromagnetic ordering at 5.6
K and a spin crossover of the intercalated [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes at different temperatures <i>T</i><sub>1/2</sub>. The three compounds present a LIESST effect with a relaxation
temperature <i>T</i><sub>LIESST</sub> inversely proportional
to <i>T</i><sub>1/2</sub>. The isostructural paramagnetic
compound, [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Zn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>2Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) was also prepared. This compound presents a
partial spin crossover of the inserted Fe<sup>III</sup> complex as
well as a LIESST effect. Finally, spectroscopic characterization of
the Fe<sup>III</sup> doped compound [Ga<sub>0.99</sub>Fe<sub>0.01</sub>(sal<sub>2</sub>trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>3Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) shows a gradual
and complete thermal spin crossover and a LIESST effect on the isolated
Fe<sup>III</sup> complexes. This result confirms that cooperativity
is not a necessary condition to observe the LIESST effect in an Fe<sup>III</sup> compound
Nonanuclear Spin-Crossover Complex Containing Iron(II) and Iron(III) Based on a 2,6-Bis(pyrazol-1-yl)pyridine Ligand Functionalized with a Carboxylate Group
The synthesis and
magnetostructural characterization of [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]Ā(ClO<sub>4</sub>)<sub>13</sub>Ā·(CH<sub>3</sub>)<sub>2</sub>CO)<sub>6</sub>Ā·(solvate) (<b>2</b>) are reported. This compound is obtained as a secondary product
during synthesis of the mononuclear complex [Fe<sup>II</sup>(bppCOOH)<sub>2</sub>]Ā(ClO<sub>4</sub>)<sub>2</sub> (<b>1</b>). The single-crystal
X-ray diffraction structure of <b>2</b> shows that it contains
the nonanuclear cluster of the formula [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]<sup>13+</sup>, which is formed by
a central Fe<sup>III</sup><sub>3</sub>O core coordinated to six partially
deprotonated [Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sup>+</sup> complexes.
Raman spectroscopy studies on single crystals of <b>1</b> and <b>2</b> have been performed to elucidate the spin and oxidation
states of iron in <b>2</b>. These studies and magnetic characterization
indicate that most of the ironĀ(II) complexes of <b>2</b> remain
in the low-spin (LS) state and present a gradual and incomplete spin
crossover above 300 K. On the other hand, the Fe<sup>III</sup> trimer
shows the expected antiferromagnetic behavior. From the structural
point of view, <b>2</b> represents the first example in which
bppCOO<sup>ā</sup> acts as a bridging ligand, thus forming
a polynuclear magnetic complex
Stimuli Responsive Hybrid Magnets: Tuning the Photoinduced Spin-Crossover in Fe(III) Complexes Inserted into Layered Magnets
The
insertion of a [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complex
cation into a 2D oxalate network in the presence of different solvents
results in a family of hybrid magnets with coexistence of magnetic
ordering and photoinduced spin-crossover (LIESST effect) in compounds
[Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHCl<sub>3</sub> (<b>1Ā·CHCl</b><sub><b>3</b></sub>), [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHBr<sub>3</sub> (<b>1Ā·CHBr</b><sub><b>3</b></sub>), and [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Br<sub>2</sub> (<b>1Ā·CH</b><sub><b>2</b></sub><b>Br</b><sub><b>2</b></sub>). The three compounds crystallize in a 2D honeycomb anionic layer
formed by Mn<sup>II</sup> and Cr<sup>III</sup> ions linked through
oxalate ligands and a layer of [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes and solvent molecules (CHCl<sub>3</sub>, CHBr<sub>3</sub>, or CH<sub>2</sub>Br<sub>2</sub>) intercalated between the 2D oxalate
network. The magnetic properties and MoĢssbauer spectroscopy
indicate that they undergo long-range ferromagnetic ordering at 5.6
K and a spin crossover of the intercalated [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes at different temperatures <i>T</i><sub>1/2</sub>. The three compounds present a LIESST effect with a relaxation
temperature <i>T</i><sub>LIESST</sub> inversely proportional
to <i>T</i><sub>1/2</sub>. The isostructural paramagnetic
compound, [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Zn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>2Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) was also prepared. This compound presents a
partial spin crossover of the inserted Fe<sup>III</sup> complex as
well as a LIESST effect. Finally, spectroscopic characterization of
the Fe<sup>III</sup> doped compound [Ga<sub>0.99</sub>Fe<sub>0.01</sub>(sal<sub>2</sub>trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>3Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) shows a gradual
and complete thermal spin crossover and a LIESST effect on the isolated
Fe<sup>III</sup> complexes. This result confirms that cooperativity
is not a necessary condition to observe the LIESST effect in an Fe<sup>III</sup> compound
Nonanuclear Spin-Crossover Complex Containing Iron(II) and Iron(III) Based on a 2,6-Bis(pyrazol-1-yl)pyridine Ligand Functionalized with a Carboxylate Group
The synthesis and
magnetostructural characterization of [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]Ā(ClO<sub>4</sub>)<sub>13</sub>Ā·(CH<sub>3</sub>)<sub>2</sub>CO)<sub>6</sub>Ā·(solvate) (<b>2</b>) are reported. This compound is obtained as a secondary product
during synthesis of the mononuclear complex [Fe<sup>II</sup>(bppCOOH)<sub>2</sub>]Ā(ClO<sub>4</sub>)<sub>2</sub> (<b>1</b>). The single-crystal
X-ray diffraction structure of <b>2</b> shows that it contains
the nonanuclear cluster of the formula [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]<sup>13+</sup>, which is formed by
a central Fe<sup>III</sup><sub>3</sub>O core coordinated to six partially
deprotonated [Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sup>+</sup> complexes.
Raman spectroscopy studies on single crystals of <b>1</b> and <b>2</b> have been performed to elucidate the spin and oxidation
states of iron in <b>2</b>. These studies and magnetic characterization
indicate that most of the ironĀ(II) complexes of <b>2</b> remain
in the low-spin (LS) state and present a gradual and incomplete spin
crossover above 300 K. On the other hand, the Fe<sup>III</sup> trimer
shows the expected antiferromagnetic behavior. From the structural
point of view, <b>2</b> represents the first example in which
bppCOO<sup>ā</sup> acts as a bridging ligand, thus forming
a polynuclear magnetic complex
Stimuli Responsive Hybrid Magnets: Tuning the Photoinduced Spin-Crossover in Fe(III) Complexes Inserted into Layered Magnets
The
insertion of a [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complex
cation into a 2D oxalate network in the presence of different solvents
results in a family of hybrid magnets with coexistence of magnetic
ordering and photoinduced spin-crossover (LIESST effect) in compounds
[Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHCl<sub>3</sub> (<b>1Ā·CHCl</b><sub><b>3</b></sub>), [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHBr<sub>3</sub> (<b>1Ā·CHBr</b><sub><b>3</b></sub>), and [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Br<sub>2</sub> (<b>1Ā·CH</b><sub><b>2</b></sub><b>Br</b><sub><b>2</b></sub>). The three compounds crystallize in a 2D honeycomb anionic layer
formed by Mn<sup>II</sup> and Cr<sup>III</sup> ions linked through
oxalate ligands and a layer of [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes and solvent molecules (CHCl<sub>3</sub>, CHBr<sub>3</sub>, or CH<sub>2</sub>Br<sub>2</sub>) intercalated between the 2D oxalate
network. The magnetic properties and MoĢssbauer spectroscopy
indicate that they undergo long-range ferromagnetic ordering at 5.6
K and a spin crossover of the intercalated [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes at different temperatures <i>T</i><sub>1/2</sub>. The three compounds present a LIESST effect with a relaxation
temperature <i>T</i><sub>LIESST</sub> inversely proportional
to <i>T</i><sub>1/2</sub>. The isostructural paramagnetic
compound, [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Zn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>2Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) was also prepared. This compound presents a
partial spin crossover of the inserted Fe<sup>III</sup> complex as
well as a LIESST effect. Finally, spectroscopic characterization of
the Fe<sup>III</sup> doped compound [Ga<sub>0.99</sub>Fe<sub>0.01</sub>(sal<sub>2</sub>trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>3Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) shows a gradual
and complete thermal spin crossover and a LIESST effect on the isolated
Fe<sup>III</sup> complexes. This result confirms that cooperativity
is not a necessary condition to observe the LIESST effect in an Fe<sup>III</sup> compound
Nonanuclear Spin-Crossover Complex Containing Iron(II) and Iron(III) Based on a 2,6-Bis(pyrazol-1-yl)pyridine Ligand Functionalized with a Carboxylate Group
The synthesis and
magnetostructural characterization of [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]Ā(ClO<sub>4</sub>)<sub>13</sub>Ā·(CH<sub>3</sub>)<sub>2</sub>CO)<sub>6</sub>Ā·(solvate) (<b>2</b>) are reported. This compound is obtained as a secondary product
during synthesis of the mononuclear complex [Fe<sup>II</sup>(bppCOOH)<sub>2</sub>]Ā(ClO<sub>4</sub>)<sub>2</sub> (<b>1</b>). The single-crystal
X-ray diffraction structure of <b>2</b> shows that it contains
the nonanuclear cluster of the formula [Fe<sup>III</sup><sub>3</sub>(Ī¼<sub>3</sub>-O)Ā(H<sub>2</sub>O)<sub>3</sub>[Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sub>6</sub>]<sup>13+</sup>, which is formed by
a central Fe<sup>III</sup><sub>3</sub>O core coordinated to six partially
deprotonated [Fe<sup>II</sup>(bppCOOH)Ā(bppCOO)]<sup>+</sup> complexes.
Raman spectroscopy studies on single crystals of <b>1</b> and <b>2</b> have been performed to elucidate the spin and oxidation
states of iron in <b>2</b>. These studies and magnetic characterization
indicate that most of the ironĀ(II) complexes of <b>2</b> remain
in the low-spin (LS) state and present a gradual and incomplete spin
crossover above 300 K. On the other hand, the Fe<sup>III</sup> trimer
shows the expected antiferromagnetic behavior. From the structural
point of view, <b>2</b> represents the first example in which
bppCOO<sup>ā</sup> acts as a bridging ligand, thus forming
a polynuclear magnetic complex
Stimuli Responsive Hybrid Magnets: Tuning the Photoinduced Spin-Crossover in Fe(III) Complexes Inserted into Layered Magnets
The
insertion of a [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complex
cation into a 2D oxalate network in the presence of different solvents
results in a family of hybrid magnets with coexistence of magnetic
ordering and photoinduced spin-crossover (LIESST effect) in compounds
[Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHCl<sub>3</sub> (<b>1Ā·CHCl</b><sub><b>3</b></sub>), [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CHBr<sub>3</sub> (<b>1Ā·CHBr</b><sub><b>3</b></sub>), and [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Br<sub>2</sub> (<b>1Ā·CH</b><sub><b>2</b></sub><b>Br</b><sub><b>2</b></sub>). The three compounds crystallize in a 2D honeycomb anionic layer
formed by Mn<sup>II</sup> and Cr<sup>III</sup> ions linked through
oxalate ligands and a layer of [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes and solvent molecules (CHCl<sub>3</sub>, CHBr<sub>3</sub>, or CH<sub>2</sub>Br<sub>2</sub>) intercalated between the 2D oxalate
network. The magnetic properties and MoĢssbauer spectroscopy
indicate that they undergo long-range ferromagnetic ordering at 5.6
K and a spin crossover of the intercalated [FeĀ(sal<sub>2</sub>-trien)]<sup>+</sup> complexes at different temperatures <i>T</i><sub>1/2</sub>. The three compounds present a LIESST effect with a relaxation
temperature <i>T</i><sub>LIESST</sub> inversely proportional
to <i>T</i><sub>1/2</sub>. The isostructural paramagnetic
compound, [Fe<sup>III</sup>(sal<sub>2</sub>-trien)]Ā[Zn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>2Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) was also prepared. This compound presents a
partial spin crossover of the inserted Fe<sup>III</sup> complex as
well as a LIESST effect. Finally, spectroscopic characterization of
the Fe<sup>III</sup> doped compound [Ga<sub>0.99</sub>Fe<sub>0.01</sub>(sal<sub>2</sub>trien)]Ā[Mn<sup>II</sup>Cr<sup>III</sup>(ox)<sub>3</sub>]Ā·CH<sub>2</sub>Cl<sub>2</sub> (<b>3Ā·CH</b><sub><b>2</b></sub><b>Cl</b><sub><b>2</b></sub>) shows a gradual
and complete thermal spin crossover and a LIESST effect on the isolated
Fe<sup>III</sup> complexes. This result confirms that cooperativity
is not a necessary condition to observe the LIESST effect in an Fe<sup>III</sup> compound