6,181 research outputs found
ABJM -Bremsstrahlung at four loops and beyond: non-planar corrections
We consider the Bremsstrahlung function associated to a 1/6-BPS Wilson loop
in ABJM theory, with a cusp in the couplings to scalar fields. We non-trivially
extend its recent four-loop computation at weak coupling to include non-planar
corrections. We have recently proposed a conjecture relating this object to
supersymmetric circular Wilson loops with multiple windings, which can be
computed via localization. We find agreement between this proposal and the
perturbative computation of the Bremsstrahlung function, including color
sub-leading corrections. This supports the conjecture and hints at its validity
beyond the planar approximation.Comment: 22 page
ABJM -Bremsstrahlung at four loops and beyond
In ABJ(M) theory a generalized cusp can be constructed out of the 1/6 BPS
Wilson line by introducing an angle in the spacial contour and/or an
angle in the internal R-symmetry space. The small angles limits of its
anomalous dimension are controlled by corresponding Bremsstrahlung functions.
In this note we compute the internal space -Bremsstrahlung function to
four loops at weak coupling in the planar limit. Based on this result, we
propose an all order conjecture for the -Bremsstrahlung function.Comment: 40 pages; v2: references added, JHEP published extended versio
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
The induction of regulatory T (T reg) cells holds considerable potential as a treatment for autoimmune diseases. We have previously shown that CD4(+)CD25(hi) T reg cells isolated from patients with active rheumatoid arthritis (RA) have a defect in their ability to suppress proinflammatory cytokine production by CD4(+)CD25(-) T cells. This defect, however, was overcome after anti-tumor necrosis factor (TNF)-alpha antibody (infliximab) therapy. Here, we demonstrate that infliximab therapy gives rise to a CD4(+)CD25(hi)FoxP3(+) T reg cell population, which mediates suppression via transforming growth factor (TGF)-beta and interleukin 10, and lacks CD62L expression, thereby distinguishing this T reg cell subset from natural T reg cells present in healthy individuals and patients with active RA. In vitro, infliximab induced the differentiation of CD62L(-) T reg cells from CD4(+)CD25(-) T cells isolated from active RA patients, a process dependent on TGF-alpha. In spite of the potent suppressor capacity displayed by this CD62L(-) T reg cell population, the natural CD62L(+) T reg cells remained defective in infliximab-treated patients. These results suggest that anti-TNF-alpha therapy in RA patients generates a newly differentiated population of T reg cells, which compensates for the defective natural T reg cells. Therefore, manipulation of a proinflammatory environment could represent a therapeutic strategy for the induction of T reg cells and the restoration of tolerance
Star product and the general Leigh-Strassler deformation
We extend the definition of the star product introduced by Lunin and
Maldacena to study marginal deformations of N=4 SYM. The essential difference
from the latter is that instead of considering U(1)xU(1) non-R-symmetry, with
charges in a corresponding diagonal matrix, we consider two Z_3-symmetries
followed by an SU(3) transformation, with resulting off-diagonal elements. From
this procedure we obtain a more general Leigh-Strassler deformation, including
cubic terms with the same index, for specific values of the coupling constants.
We argue that the conformal property of N=4 SYM is preserved, in both beta-
(one-parameter) and gamma_{i}-deformed (three-parameters) theories, since the
deformation for each amplitude can be extracted in a prefactor. We also
conclude that the obtained amplitudes should follow the iterative structure of
MHV amplitudes found by Bern, Dixon and Smirnov.Comment: 21 pages, no figures, JHEP3, v2: references added, v3: appendix A
added, v4: clarification in section 3.
A matrix model for the latitude Wilson loop in ABJM theory
In ABJ(M) theory, we propose a matrix model for the exact evaluation of BPS
Wilson loops on a latitude circular contour, so providing a new weak-strong
interpolation tool. Intriguingly, the matrix model turns out to be a particular
case of that computing torus knot invariants in Chern-Simons
theory. At weak coupling we check our proposal against a three-loop
computation, performed for generic framing, winding number and representation.
The matrix model is amenable of a Fermi gas formulation, which we use to
systematically compute the strong coupling and genus expansions. For the
fermionic Wilson loop the leading planar behavior agrees with a previous string
theory prediction. For the bosonic operator our result provides a clue for
finding the corresponding string dual configuration. Our matrix model is
consistent with recent proposals for computing Bremsstrahlung functions exactly
in terms of latitude Wilson loops. As a by-product, we extend the conjecture
for the exact Bremsstrahlung function to generic
representations and test it with a four-loop perturbative computation. Finally,
we propose an exact prediction for at unequal gauge group ranks.Comment: 73 pages; v2: several improvements, JHEP published versio
Parallel Implementation of Efficient Search Schemes for the Inference of Cancer Progression Models
The emergence and development of cancer is a consequence of the accumulation
over time of genomic mutations involving a specific set of genes, which
provides the cancer clones with a functional selective advantage. In this work,
we model the order of accumulation of such mutations during the progression,
which eventually leads to the disease, by means of probabilistic graphic
models, i.e., Bayesian Networks (BNs). We investigate how to perform the task
of learning the structure of such BNs, according to experimental evidence,
adopting a global optimization meta-heuristics. In particular, in this work we
rely on Genetic Algorithms, and to strongly reduce the execution time of the
inference -- which can also involve multiple repetitions to collect
statistically significant assessments of the data -- we distribute the
calculations using both multi-threading and a multi-node architecture. The
results show that our approach is characterized by good accuracy and
specificity; we also demonstrate its feasibility, thanks to a 84x reduction of
the overall execution time with respect to a traditional sequential
implementation
Electronic-enthalpy functional for finite systems under pressure
We introduce the notion of electronic enthalpy for first-principles
structural and dynamical calculations of finite systems under pressure. An
external pressure field is allowed to act directly on the electronic structure
of the system studied via the ground-state minimization of the functional
, where is the quantum volume enclosed by a charge
isosurface. The Hellmann-Feynman theorem applies, and assures that the ionic
equations of motion follow an isoenthalpic dynamics. No pressurizing medium is
explicitly required, while coatings of environmental ions or ligands can be
introduced if chemically relevant. We apply this novel approach to the study of
group-IV nanoparticles during a shock wave, highlighting the significant
differences inthe plastic or elastic response of the diamond cage under load,
and their potential use as novel nanostructured impact-absorbing materials.Comment: 4 pages, 4 figure
Theory of double-resonant Raman spectra in graphene: intensity and line shape of defect-induced and two-phonon bands
We calculate the double resonant (DR) Raman spectrum of graphene, and
determine the lines associated to both phonon-defect processes, and two-phonons
ones. Phonon and electronic dispersions reproduce calculations based on density
functional theory corrected with GW. Electron-light, -phonon, and -defect
scattering matrix elements and the electronic linewidth are explicitly
calculated. Defect-induced processes are simulated by considering different
kind of idealized defects. For an excitation energy of eV, the
agreement with measurements is very good and calculations reproduce: the
relative intensities among phonon-defect or among two-phonon lines; the
measured small widths of the D, , 2D and lines; the line shapes; the
presence of small intensity lines in the 1800, 2000 cm range. We
determine how the spectra depend on the excitation energy, on the light
polarization, on the electronic linewidth, on the kind of defects and on their
concentration. According to the present findings, the intensity ratio between
the and 2D lines can be used to determine experimentally the electronic
linewidth. The intensity ratio between the and lines depends on the
kind of model defect, suggesting that this ratio could possibly be used to
identify the kind of defects present in actual samples. Charged impurities
outside the graphene plane provide an almost undetectable contribution to the
Raman signal
Electron Transport and Hot Phonons in Carbon Nanotubes
We demonstrate the key role of phonon occupation in limiting the high-field
ballistic transport in metallic carbon nanotubes. In particular, we provide a
simple analytic formula for the electron transport scattering length, that we
validate by accurate first principles calculations on (6,6) and (11,11)
nanotubes. The comparison of our results with the scattering lengths fitted
from experimental I-V curves indicates the presence of a non-equilibrium
optical phonon heating induced by electron transport. We predict an effective
temperature for optical phonons of thousands Kelvin.Comment: 4 pages, 1 figur
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