Odds ratios (ORs) and 95% confidence intervals for the associations of energy-related indicators with breast cancer by race and menopausal status, the Nashville Breast Health Study.

<p>^aOdds ratio (OR) and 95% confidence interval (CI) adjusted for age, education, history of breast cancer in first degree relatives, OC use, and age at menarche.</p><p>^bAdditionally adjusted for HRT use.</p><p>^cAdditionally adjusted for weight at age 18.</p><p>Odds ratios (ORs) and 95% confidence intervals for the associations of energy-related indicators with breast cancer by race and menopausal status, the Nashville Breast Health Study.</p

Comparison of cases and controls for demographic characteristics and breast cancer risk factors by race, the Nashville Breast Health Study.

<p>Comparison of cases and controls for demographic characteristics and breast cancer risk factors by race, the Nashville Breast Health Study.</p

Race-gender specific geographic distribution of the Common Factor.

<p>USA. 1999–2006.</p

Factor loading and alpha-reliability from principal components analysis.

<p>Factor loading and alpha-reliability from principal components analysis.</p

Race-gender-specific correlations between age-adjusted (25 to 64 years) mortality from selected causes of death and race-specific infant mortality (zero order) for non-Hispanics in 416 US Central and Fringe Metropolitan Counties, 1999–2010.

<p>*** = p<0.001; * = p<0.05.</p><p>Race-gender-specific correlations between age-adjusted (25 to 64 years) mortality from selected causes of death and race-specific infant mortality (zero order) for non-Hispanics in 416 US Central and Fringe Metropolitan Counties, 1999–2010.</p

Additional file 1: of Pragmatic trial of an intervention to increase human papillomavirus vaccination in safety-net clinics

Supplementary Material. (DOC 1220 kb

Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women

<div><p>Genome-wide association studies (GWAS), conducted mostly in European or Asian descendants, have identified approximately 67 genetic susceptibility loci for breast cancer. Given the large differences in genetic architecture between the African-ancestry genome and genomes of Asians and Europeans, it is important to investigate these loci in African-ancestry populations. We evaluated index SNPs in all 67 breast cancer susceptibility loci identified to date in our study including up to 3,300 African-American women (1,231 cases and 2,069 controls), recruited in the Southern Community Cohort Study (SCCS) and the Nashville Breast Health Study (NBHS). Seven SNPs were statistically significant (<i>P</i>≤0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/<i>TERT</i>), rs999737 (14q24/<i>RAD51L1</i>), rs13387042 (2q35/<i>TNP1</i>), rs1219648 (10q26/<i>FGFR2</i>), rs8170 (19p13/<i>BABAM1</i>), rs17817449 (16q12/<i>FTO</i>), and rs13329835 (16q23/<i>DYL2</i>). A marginally significant association (<i>P</i><0.10) was found for three additional SNPs: rs1045485 (2q33/<i>CASP8</i>), rs4849887 (2q14/<i>INHBB</i>), and rs4808801 (19p13/<i>ELL</i>). Three additional SNPs, including rs1011970 (9p21/<i>CDKN2A/2B</i>), rs941764 (14q32/<i>CCDC88C</i>), and rs17529111 (6q14/<i>FAM46A</i>), showed a significant association in analyses conducted by breast cancer subtype. The risk of breast cancer was elevated with an increasing number of risk variants, as measured by quintile of the genetic risk score, from 1.00 (reference), to 1.75 (1.30–2.37), 1.56 (1.15–2.11), 2.02 (1.50–2.74) and 2.63 (1.96–3.52), respectively, (<i>P</i> = 7.8×10^–10). Results from this study highlight the need for large genetic studies in AAs to identify risk variants impacting this population.</p></div

Association of genetic risk score (GRS) with breast cancer risk in African Americans.

a<p>GRS was constructed based on 8 SNPs, including rs1045485, rs10069690, rs999737, rs8170, rs4849887, rs17817449, rs13329835 and rs4808801.</p>b<p>Adjusted for age, study, and the first ten principal components.</p

Characteristics of study participants.

a<p>The Nashville Breast Health Study.</p>b<p>The Southern Community Cohort Study.</p>c<p>Among parous women.</p

Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.

<p>Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.</p