Association of ECG findings with low ejection fraction and elevated right ventricular systolic pressure on echocardiogram.

<p>Association of ECG findings with low ejection fraction and elevated right ventricular systolic pressure on echocardiogram.</p

Frequencies of different ECG findings and their impact on mortality in the GENISOS cohort.

<p>Frequencies of different ECG findings and their impact on mortality in the GENISOS cohort.</p

Characteristics of patients with and without ECG abnormalities in the GENISOS Study Population.

<p>Characteristics of patients with and without ECG abnormalities in the GENISOS Study Population.</p

Clinical correlates of monospecific anti-PM75 and anti-PM100 antibodies in a tri-nation cohort of 1574 systemic sclerosis subjects

<div><p></p><p><i>Objective</i>: Autoantibodies directed against the two principal antigens of the human exosome complex, PM75 and PM100, are present in systemic sclerosis (SSc) sera and have been associated with myositis and calcinosis. However, there is a paucity of data on the clinical correlates of these autoantibodies separately and in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of monospecific anti-PM75 and anti-PM100 in SSc. <i>Methods</i>: A tri-nation cohort of 1574 SSc subjects was formed, clinical variables were harmonized and sera were tested for anti-PM75 and anti-PM100 antibodies using a line immunoassay. <i>Results</i>: Forty-eight (3.0%) subjects had antibodies against PM75 and 18 (1.1%) against PM100. However, only 16 (1%) had monospecific anti-PM75 antibodies and 11 (0.7%) monospecific anti-PM100 antibodies (i.e. in isolation of each other and other SSc-specific antibodies). Monospecific profiles of each autoantibody included more calcinosis. An increased frequency of myositis was only seen in subjects positive for both anti-PM75 and anti-PM100 antibodies. Lung disease was only associated with anti-PM75 and subjects with anti-PM100 antibodies had better survival compared to other antibody subsets. <i>Conclusion</i>: The prevalence of monospecific anti-PM75 and anti-PM100 antibodies in this large SSc cohort was low. Disease features associated with anti-PM/Scl antibodies may depend on particular and possibly multiple antigen specificities. However, due to the small samples, these results need to be interpreted with caution. International collaborations are key to understanding the clinical correlates of uncommon serological profiles in SSc.</p></div

Comparisons between controls and SSc subsets.

*<p>PF =  pulmonary fibrosis; nominal significance <i>p</i> value <0.05; Bonferroni correction for significance was calculated as <i>p</i><0.0013.</p

Distribution of major HLA-DPB1 alleles in Chinese controls and SSc patients.

<p>OR = odds ratio; CI =  confidence interval; nominal significance <i>p</i> value<0.05; Bonferroni correction for significance was calculated as <i>p</i><0.0013.</p

Differentiation of SSc subsets and clinical outcomes with specific HLA-DPB1 alleles.

<p>Notes: DPB1*04 only occurred in heterozygotes, heterozygous DPB1*05:01 did not show any association with SSc subsets.</p

Comparisons between SSc subsets and controls.

<p>*nominal significance level: P<0.05; Bonferroni correction for significance was calculated as P<0.0025.</p><p>Comparisons between SSc subsets and controls.</p

toutan

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Two-digit allele frequencies of HLA-DRB1 between SSc subsets and controls.

<p>*nominal significance level: P<0.05; Bonferroni correction for significance was calculated as P<0.0038. For DRB1*15, two major subtypes also were displayed.</p><p>Two-digit allele frequencies of HLA-DRB1 between SSc subsets and controls.</p