Randomized phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced soft-tissue sarcoma

JX-594 is an oncolytic vaccinia virus genetically modified to replicate selectively in tumor cells. Metronomic chemotherapy has shown preclinical synergy with oncolytic viruses. We report here the results of the METROMAJX which is a randomized phase II clinical trial investigating the combination of JX-594 combined with metronomic cyclophosphamide (arm 1) or metronomic cyclophosphamide (arm 2) in patients with advanced STS. A two-stage Simon design was used. JX-594 was administered intra-venously at the dose 1.109 every 2 weeks for the first 3 injections and then every 3 weeks. Cyclophosphamide was given orally at the dose of 50 mg BID 1 week on 1 week off. The primary endpoint was the 6-month non progression rate. 20 patients were included (arm 1:15, arm 2:5). The two most frequent toxicities were grade 1 fatigue and fever and grade 2 fatigue and grade 2 lymphopenia in arms 1 and 2, respectively. In arm 1, 12 patients were assessable for the efficacy analysis. None of them were progression-free at 6 months indicating that the first stage of the Simon's design was not satisfied. One patient out 4 assessable for efficacy was progression-free at 6 months in arm 2. High throughput analysis of sequential plasma samples revealed an upregulation of protein biomarkers reflecting immune induction such as CXCL10 and soluble CD8 antigen in arm 1. Systemic treatment with JX-594 is safe in patients with advanced STS. Further investigations are needed to improve immune response to oncolytic viruses and define their therapeutic potential in patients with STS

Projet ESPOL. Synthèse des travaux menés par l'URSOLS

Projet ESPOL. Synthèse des travaux menés par l'URSOL

Rôle des récepteurs de type 2 de la Bradykinine et de l'Angiotensine II dans le remodelage induit par des variations de débit sanguin

ANGERS-BU Médecine-Pharmacie (490072105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Milieux poreux et transferts hydriques

Bulletin du GFHNNational audienc

Using proximal electromagnetic/electrical resistivity sensors to assess soil health

International audienceSoil health assessment can be understood as a synthetic approach using complex indicators including a variety of soil physical and biological characteristics. The electrical/electromagnetic properties, whilst limited in number, are directly linked with some of the most relevant soil parameters characterizing soil health. Their measurement can be implemented through non-invasive techniques allowing to map with a fine mesh the whole surface in question and to recognize the vertical distribution of layers. They offer thus a 3D holistic approach. After a short summary of the soil health concern, the chapter recalls the definitions of the three relevant properties (conductivity, permittivity, magnetic susceptibility), and details the different electrical and electromagnetic techniques used in the soil domain. Two case studies in temperate and arid climates illustrate what can be obtained when using these techniques. A short discussion underlines the perspectives offered by a holistic approach to evaluate soil health characteristics from geophysical measurements

Using proximal electromagnetic/electrical resistivity (ER)/electrical impedance spectroscopy sensors to assesssoil health and water status

International audienceSoil Health assessment can be understood as a synthetic approach using complex indicators including a variety of soil physical and biological characteristics. The electrical/electromagnetic properties, whilst limited in number, are directly linked with some of the most relevant soil parameters characterizing Soil Health. Their measurement can be implemented through non-invasive techniques allowing to map with a fine mesh the whole surface in question and to recognize the vertical distribution of layers. They offer thus a 3D holistic approach. After a short summary to the Soil Health concern, the chapter recalls the definitions of the three relevant properties (conductivity, permittivity, magnetic susceptibility), and details the different electrical and electromagnetic techniques used in the soil domain. Two case studies in temperate and arid climates illustrate what can be obtained when using these techniques. A short discussion underlines the perspectives offered by a holistic approach to evaluate Soil Health characteristics from geophysical measurements

Identifying the characteristic scales of soil structural recovery after compaction from three in-field methods of monitoring

International audienceHighlights • Soil structural changes were assessed in-field from one-year soil monitoring. • Methods of description were invasive (coring, visual) and geophysical (ERT). • The study shows a characteristic time-scale of soil structural recovery longer than 1year. • Some regenerative processes were identified at seasonal scale from temporal ERT. • Cracking occurred in the topsoil, abruptly in the dry period, still visible in the wet and cool. Abstract The impact of compaction by traffic on agricultural soils is not strict and irreversible. After compaction by machine traffic, soil structure changes both spatially and temporally as different generative processes occur. These are generally well-described in the literature. However, the preferential periods of occurrence and the soil depths affected by changes – thus, the characteristic scales of soil structural recovery – remain hypothetical. Further investigation through precise spatial and temporal monitoring under real in-field soil conditions is needed. In this paper, the structural changes of a locally trafficked silt–loam soil were assessed under both cropped and bare areas conventionally tilled from one-year soil monitoring. The monitoring was performed in-field by three methods at a low temporal resolution with the standard methods of visual description and soil coring in pits, and at a high temporal resolution with the non-destructive Electrical Resistivity Tomography (ERT) method. The specific use of ERT for this purpose is discussed. Compaction by traffic affected the overall tilled soil layer and was shown to be time-persistent. This suggested a characteristic time-scale of a complete structural recovery longer than one year, regardless of soil management. At the finest temporal scale, the results also highlighted some seasonal processes that potentially affect the long-term recovery, such as bio-drilling and soil cracking. The processes were related to the soil management, the wetting/drying cycles and the freeze/thaw effect. They likewise induced the start of structure fragmentation in the first centimetres of the soil and acted abruptly in the dry period, preferentially under the area initially cropped, with persistent effects on the soil structure in the rainy and cool season