Screening for Dementia: An examination of subscale relative importance

Approximately 13 percent of the American population are 65 years of age or older (Vincent & Velkof, 2010). Of these 48 million older adults, roughly 5.3 million have received a clinical diagnosis of Alzheimer’s disease (AD) (Alzheimer’s Association, 2017). As the awareness of AD continues to heighten, so does the push for increased cognitive screening to identify signs of abnormal aging. However, important considerations pertaining to scale development or weighting procedures applied during the test development process remain unclear, as they are often not reported in testing manuals. The current study presents a statistically derived scoring algorithm for a brief screening measure of cognition, the Mattis Dementia Rating Scale 2 (DRS-2) in a sample of 113 older adults (55 Alzheimer’s disease dementia, 58 Mild Cognitive Impairment. Logit weights obtained from logistic regression analysis were utilized to re-weight the subscales of the DRS-2 to reflect the order of relative importance of the five DRS-2 subscales. Sensitivity and specificity rates of the original and logit-weighted DRS-2 scores were compared to examine the impact of weighting on DRS-2 classification accuracy. Results indicated an increase in sensitivity from 78% to 90% and a decrease in specificity utilizing the newly computed logit-weighted scores. These results highlight the importance of scale construction during the instrument development process, suggesting that weighting procedures directly affect measurement utility. Additional implications for future clinical practice and research are discussed

A Rubric for Evaluating and Designing Survey Research in Neuropsychology

The current study presents recommended guidelines for neuropsychologists in accordance with best practices used in survey research design and data reporting. Although there have been improvements in the quality of research design and data reporting of neuropsychological surveys over time, several areas are still in need of improvement. A rubric, created from these recommended guidelines, is intended to provide neuropsychologists with an easily accessible tool to help further improve the quality of of survey research in neuropsychology

Dissociating Statistically Determined Normal Cognitive Abilities and Mild Cognitive Impairment Subtypes with DCTclock.

OBJECTIVE: To determine whether the DCTclock can detect differences across groups of patients seen in the memory clinic for suspected dementia. METHOD: Patients (n = 123) were classified into the following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic cognitive impairment (aMCI), and mixed/dysexecutive cognitive impairment (mx/dysMCI). Nine outcome variables included a combined command/copy total score and four command and four copy indices measuring drawing efficiency, simple/complex motor operations, information processing speed, and spatial reasoning. RESULTS: Total combined command/copy score distinguished between groups in all comparisons with medium to large effects. The mx/dysMCI group had the lowest total combined command/copy scores out of all groups. The mx/dysMCI group scored lower than the CN group on all command indices ( CONCLUSIONS: These results suggest that DCTclock command/copy parameters can dissociate CN, SbCI, and MCI subtypes. The larger effect sizes for command clock indices suggest these metrics are sensitive in detecting early cognitive decline. Additional research with a larger sample is warranted

Visual and Verbal Serial List Learning in Patients with Statistically-Determined Mild Cognitive Impairment.

Background and Objective: Prior research with patients with mild cognitive impairment (MCI) suggests that visual versus verbal episodic memory test performance may be more sensitive to emergent illness. However, little research has examined visual versus verbal episodic memory performance as related to MCI subtypes. Research Design and Methods: Patients were diagnosed with non-MCI, amnestic MCI (aMCI), and combined mixed/dysexecutive MCI (mixed/dys MCI). Visual and verbal episodic memory were assessed with the Brief Visuospatial Memory Test-Revised (BVMT-R) and the 12-word Philadelphia (repeatable) Verbal Learning Test (P[r]VLT), respectively. Results: BVMT-R and P(r)VLT scores yielded similar between-group patterns of performance. Non-MCI patients scored better than other groups on all parameters. aMCI and mixed/dys MCI did not differ on immediate or delayed free recall. Both delayed BVMT-R and P(r)VLT recognition test performance dissociated all three groups. Logistic regression analyses found that BVMT-R delayed free recall and delayed recognition scores correctly classified more patients with MCI (75.40%) than analogous P(r)VLT scores (66.20%). Visual versus verbal memory within-group analyses found no differences among non-MCI patients; P(r)VLT immediate free recall was worse among aMCI patients, but BVMT-R immediate free recall and delayed recognition were worse among mixed/dys MCI patients. Discussion and Implications: Between-group analyses found convergent patterns of performance such that both tests identified elements of amnesia. However, logistic and within-group analyses found differing performance patterns suggesting that impaired visual episodic memory performance may be specific to emergent illness in mixed/dys MCI. Complementary but divergent neurocognitive networks may underlie visual versus verbal episodic memory performance in some patients with MCI

Normative References for Graphomotor and Latency Digital Clock Drawing Metrics for Adults Age 55 and Older: Operationalizing the Production of a Normal Appearing Clock

Background: Relative to the abundance of publications on dementia and clock drawing, there is limited literature operationalizing ‘normal’ clock production. Objective: To operationalize subtle behavioral patterns seen in normal digital clock drawing to command and copy conditions. Methods: From two research cohorts of cognitively-well participants age 55 plus who completed digital clock drawing to command and copy conditions (n = 430), we examined variables operationalizing clock face construction, digit placement, clock hand construction, and a variety of time-based, latency measures. Data are stratified by age, education, handedness, and number anchoring. Results: Normative data are provided in supplementary tables. Typical errors reported in clock research with dementia were largely absent. Adults age 55 plus produce symmetric clock faces with one stroke, with minimal overshoot and digit misplacement, and hands with expected hour hand to minute hand ratio. Data suggest digitally acquired graphomotor and latency differences based on handedness, age, education, and anchoring. Conclusion: Data provide useful benchmarks from which to assess digital clock drawing performance in Alzheimer’s disease and related dementias.</jats:p