Appendiceal abscess in a giant left-sided inguinoscrotal hernia: a rare case of Amyand hernia

The hernia of Amyand is an inguinal hernia containing the appendix in the sac. It is a rare pathology often diagnosed only intra-operatively. We report a case even more rare of a giant left-sided inguinoscrotal Amyand hernia with appendiceal abscess without clinical findings of incarceration/strangulation, occlusion, perforation, or acute scrotum and with the presence in the sac of the caecum and other anatomical structures (last ileal loops, bladder and omentum). The 68-years-old man patient successfully underwent surgical treatment only through the hernia sac (meshless repair according to Postempski technique)

Occlusione intestinale su briglia in paziente con pregressa diagnosi di sindrome di Ogilv

A case of a 72-year-old man with abdominal pain and ileus is reported. Previous surgery for Ogilvie?s syndrome had been performed. Despite conservative therapy, the occlusive symptoms worsen. Therefore the patient was submitted to surgery. At laparotomy two abdominal adhesions were found and sectioned. The differential diagnosis between mechanical ileus and pseudo-obstruction for neuro-mechanics dissociation (Ogilvie?s syndrome) is difficult, particularly in patients with neurodegenerative diseases

[Gangrene of Meckel's diverticulum in strangulated left inguinal hernia].

We report a case of a 57-year-old woman admitted for abdominal pain and a not reducible mass in left inguino-abdominal region. With a diagnosis of strangulated inguinal hernia, the patient underwent urgent surgery. The surgical exploration showed a gangrenous intestinal loop with a Meckel's necrotic diverticulum. A small bowel resection (20 cm) was performed. The post-operative course was uneventful. This seems the first case reported in the literature of woman with a Meckel's diverticulum involved in a strangulated left inguinal hernia

UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice

Glioblastoma multiforme (GBM) is the most malignant brain tumor, showing high resistance to standard therapeutic approaches that combine surgery, radiotherapy, and chemotherapy. As opposed to healthy tissues, EphA2 has been found highly expressed in specimens of glioblastoma, and increased expression of EphA2 has been shown to correlate with poor survival rates. Accordingly, agents blocking Eph receptor activity could represent a new therapeutic approach. Herein, we demonstrate that UniPR1331, a pan Eph receptor antagonist, possesses significant in vivo anti-angiogenic and anti-vasculogenic properties which lead to a significant anti-tumor activity in xenograft and orthotopic models of GBM. UniPR1331 halved the final volume of tumors when tested in xenografts (p<0.01) and enhanced the disease-free survival of treated animals in the orthotopic models of GBM both by using U87MG cells (40 vs 24 days of control, p<0.05) or TPC8 cells (52 vs 16 days, p<0.01). Further, the association of UniPR1331 with the anti-VEGF antibody Bevacizumab significantly increased the efficacy of both monotherapies in all tested models. Overall, our data promote UniPR1331 as a novel tool for tackling GBM

Cancro ereditario. Il counseling nelle donne a rischio

Alcune specifiche sindromi genetiche comportano un rischio elevato di cancro della mammella e dell’ovaio, per cui sono indicati in queste pazienti una accurata valutazione genetica mirata e il relativo counseling.Specific genetic syndromes convey a high risk for breast and ovarian cancer, as well as reasons to refer a patient for comprehensive cancer genetics evaluation and counseling

Nuovi biomarcatori per la diagnosi di carcinoma ovarico: OVA1 e ROMA

L’utilizzo mirato di questi nuovi test può migliorare i risultati nelle donne con masse annessiali o carcinoma ovarico epiteliale.Selective use of these new tests may lead to better outcomes for women with adnexal masses or epithelial ovarian cancer

L’isterectomia addominale è un intervento obsoleto?

L’isterectomia addominale è obsoleta? Non ancora. Persistono scenari in cui essa è appropriata come, ad esempio, un utero notevolmente aumentato di volume per patologia maligna, ovvero una situazione in cui la morcellazione non è indicata. Inoltre, se un chirurgo si trova ad operare in aree remote senza disponibilità di competenze e consulenze, l’approccio addominale può essere la scelta più sicura

Diabete gestazionale. Si possono usare gli ipoglicemizzanti orali?

Gli ipoglicemizzanti orali in commercio sono generalmente sicuri ed efficaci anche in gravidanza e comportano per il feto rischi di gran lunga inferiori a quelli di un diabete gestazionale non trattato