The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study

This observational cohort study by Andrew Edmonds and colleagues reports that treatment with highly active antiretroviral therapy (HAART) markedly improves the survival of HIV-infected children in Kinshasa, DRC, a resource-deprived setting

Quantification of CD4 Responses to Combined Antiretroviral Therapy Over 5 Years Among HIV-Infected Children in Kinshasa, Democratic Republic of Congo

The long-term effects of combined antiretroviral therapy (cART) on CD4 percentage in HIV-infected children are incompletely understood, with evidence from resource-deprived areas particularly scarce even though most children with HIV live in such settings. We sought to describe this relationship

Fertility desires, unmet need for family planning, and unwanted pregnancies among HIV-infected women in care in Kinshasa, DR Congo

Abstract Introduction: we assessed the fertility desires, utilization of family planning (FP) methods, and incidence of pregnancies among HIV-infecte

Estimated effect of HAART on mortality among 790 HIV-infected children initiating HIV care in Kinshasa, DRC, between December 2004 and May 2010.

<p>All estimates are derived from pooled logistic models that include time modeled as a restricted cubic spline with four knots. Comparing HAART to no HAART, the unadjusted mortality rate ratio was 0.54 (95% CI 0.34–0.85), while the unadjusted ratio of 3-y mortality risks was 0.31 (95% CI 0.23–0.43).</p

Number of active children by month of follow-up and HAART status.

<p>The timing of HAART initiation, in addition to the reduction in population size over time due to death, transfer to a different care provider, or loss to follow-up, is illustrated.</p

Characteristics of 790 HIV-infected children initiating HIV care in Kinshasa, DRC, between December 2004 and May 2010.

a<p><i>p</i>-Values are for the comparison of children who received HAART to children who did not receive HAART.</p>b<p>Baseline was date of first CD4 percentage result for 41 of 790 children (5.2%) for whom CD4 percentage at enrollment was not available. For these 41 children, the median number of months from enrollment to first CD4 percentage was 2.3 (IQR 1.1–5.3).</p

Cumulative incidence curves depicting the effect of HAART on survival among 790 HIV-infected children.

<p>In (A), the curves are unweighted. In (B), the curves are weighted by the IPTCV.</p