Relato de caso: Paraganglioma retroperitoneal ocasionando dor abdominal e níveis de pressão arterial dentro da normalidade: Relato de caso: Paraganglioma retroperitoneal ocasionando dor abdominal e níveis de pressão arterial dentro da normalidade

Paragangliomas são neoplasias neuroendócrinas com origem na paraganglia do sistema nervoso simpático e parassimpático. O diagnóstico é um desafio, quando os sintomas e os aspectos de imagem são inespecíficos. Apresentamos uma paciente do sexo feminino, 34 anos, com dor abdominal e níveis normais de pressão arterial sistêmica. Uma massa abdominal hipervascular foi visualizada no retroperitônio através dos exames de imagem, sendo submetida à biópsia percutânea guiada por ultrassonografia. O diagnóstico final foi paraganglioma retroperitoneal, não funcionante, estabelecido por meio da análise histopatológica e imuno-histoquímica dos fragmentos. Nosso objetivo é alertar os médicos sobre a possibilidade do paraganglioma em cenário clínico atípico

Intravenous human umbilical cord-derived mesenchymal stromal cell administration in models of moderate and severe intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is as a life-threatening condition that can occur in young adults, often causing long-term disability. Recent preclinical data suggests mesenchymal stromal cell (MSC)-based therapies as promising options to minimize brain damage after ICH. However, therapeutic evidence and mechanistic insights are still limited, particularly when compared to other disorders such as ischemic stroke. Herein, we employed a model of collagenase-induced ICH in young adult rats to investigate the potential therapeutic effects of an intravenous injection of human umbilical cord Wharton's jelly-derived MSCs (hUC-MSCs). Two doses of collagenase were used to cause moderate or severe hemorrhages. Magnetic resonance imaging showed that animals treated with hUC-MSCs after moderate ICH had smaller residual hematoma volumes than vehicle-treated rats, whereas the cell therapy failed to decrease the hematoma volume in animals with a severe ICH. Functional assessments (rotarod and elevated body swing tests) were performed for up to 21 days after ICH. Enduring neurological impairments were seen only in animals subjected to severe ICH, but the cell therapy did not induce statistically significant improvements in the functional recovery. The biodistribution of Technetium-99m-labeled hUC-MSCs was also evaluated, showing that most cells were found in organs such as the spleen and lungs 24 h after transplantation. Nevertheless, it was possible to detect a weak signal in the brain, which was higher in the ipsilateral hemisphere of rats subjected to a severe ICH. These data indicate that hUC-MSCs have moderately beneficial effects in cases of less severe brain hemorrhages in rats by decreasing the residual hematoma volume, and that optimization of the therapy is still necessary