Asciminib mitigates DNA damage stress signaling induced by cyclophosphamide in the ovary

Cancer treatments often have adverse effects on the quality of life for young women. One of the most relevant negative impacts is the loss of fertility. Cyclophosphamide is one of the most detrimental chemotherapeutic drugs for the ovary. Cyclophosphamide may induce the destruction of dormant follicles while promoting follicle activation and growth. Herein, we demonstrate the in vivo protective effect of the allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on signalling pathways activated by cyclophosphamide in mouse ovaries. Besides, we provide evidence that Asciminib did not interfere with the cytotoxic effect of cyclophosphamide in MCF7 breast cancer cells. Our data indicate that concomitant administration of Asciminib mitigates the cyclophosphamide-induced ovarian reserve loss without preventing the anticancer potential of cyclophosphamide. Altogether these observations are relevant for the development of effective ferto-protective adjuvants to preserve the ovarian reserve from the damaging effect of cancer therapies

The Origin of Transverse Flow at the SPS

We study the transverse expansion in central Pb+Pb collisions at the CERN SPS. Strong collective motion of hadrons can be created. This flow is mainly due to meson baryon rescattering. It allows to study the angular distribution of intermediate mass meson baryon interactions.Comment: submitted to Phys. Lett.

Three-body problem at finite temperature and density

We derive practical three-body equations for the equal-time three-body Green function in matter. Our equations describe both bosons and fermions at finite density and temperature, and take into account all possible two-body sub-processes allowed by the underlying Hamiltonian.Comment: 24 pages, revtex

QCD equation of state in a virial expansion

We describe recent three-flavor QCD lattice data for the pressure, speed of soun d and interaction measure at nonzero temperature and vanishing chemical potentia l within a virial expansion. For the deconfined phase we use a phenomenological model which includes non-pert urbative effects from dimension two gluon condensates that reproduce the free en ergy of quenched QCD very well. The hadronic phase is parameterized by a generalized resonance-gas model. Furthermore, we extend this approach to finite quark densities introducing an ex plicit $\mu$-dependence of the interaction. We calculate pressure, quark-number density, entropy and energy density and compare to results of lattice calculatio ns. We, additionally, investigate the structure of the phase diagram by calculating the isobaric and isentropic lines as well as the critical endpoint in the ($T, \mu_q$)-plane.Comment: 9 pages, 11 figures. Submitted to Phys. Rev.

Dibaryons with Strangeness: their Weak Nonleptonic Decay using SU(3) Symmetry and how to find them in Relativistic Heavy-Ion Collisions

Weak SU(3) symmetry is successfully applied to the weak hadronic decay amplitudes of octet hyperons. Weak nonmesonic and mesonic decays of various dibaryons with strangeness, their dominant decay modes, and lifetimes are calculated. Production estimates for BNL's Relativistic Heavy-Ion Collider are presented employing wave function coalescence. Signals for detecting strange dibaryon states in heavy-ion collisions and revealing information about the unknown hyperon-hyperon interactions are outlined.Comment: 4 pages, 2 figures, uses RevTeX, discussion about the model of the weak decay and experimental signals extended, references update

A series of new conjugated oligothiophenes for organic electronics

Thiophene oligomers and polymers can be found in a huge number of materials with applications in the field of Organic Electronics. Chemical and electrochemical syntheses along with electrochemical studies and complete characterization of a series of new conjugated oligothiophene derivatives are reported. Two different molecular architectures, D-A (donor-acceptor) and A-D-A (acceptor-donor-acceptor), were taken into account. The results from voltammetric experiments and optical studies confirm the close relationship between the structure of these compounds and their electrochemical behaviour. This series of oligothiophenes shows low bandgaps, a mandatory requirement for their use in Organic Electronics, and, clearly, they are promising candidates for future synthetic studies in order to modify their optical and electrochemical properties to achieve better performances as organic semiconductors

High performance liquid chromatography coupled with mass spectrometry for/and nanomaterials: an overview

The story of mass spectrometry applied to the nanoparticles world is very young but actually it is expected to evolve as one of the most powerful tool for the characterization of the smaller-size nanoparticles in terms of composition, size, shape, surface chemistry, because of its versatility, sensitivity, reliability and the possibility to be coupled with high performance chromatographic separation techniques. A short overview on different fields where liquid chromatography coupled with mass spectrometry, nanomaterials and nanotechnology come together is herein given