ERMES: Design and preliminary simulations for an autonomous docking manoeuvre

In the last decades, small satellites have played an important role in space missions. Due to their reduced dimension and costs, they became affordable to smaller companies and research laboratories to conduct scientific experiments and technological demonstrations in space. In addition, the number of these satellites has considerably increased due to their wide use in technological, scientific and commercial domains. In this scenario, autonomous architectures, as well as miniaturized mechanical subsystems for small satellites, are continuously investigated. Experimental Rendezvous in Microgravity Environment Study (ERMES) is a student project that focuses on the simulation of an autonomous docking manoeuvres between two CubeSats mock-ups equipped with miniaturized Guidance Navigation and Control systems and mechanical docking interfaces. ERMES aims to integrate different subsystems for autonomous docking, to increase the Technology Readiness Level and to study possible applications for in-orbit servicing. This paper deals with the design and development of the tests for autonomous docking manoeuvres between two CubeSats mock-ups to be performed in a reduced-gravity environment during a parabolic flight. A Target-Chaser configuration has been selected, where the Chaser is fully active and the Target is cooperative. The Chaser is equipped with a miniaturized cold gas propulsion system with eight thrusters to control its attitude and position; in contrast, the Target has a set of three reaction wheels to control only its attitude. The tested miniaturized mechanical docking interfaces employs a probe-drogue configuration. The most demanding aspect of the development phase will be the dedicated software for the proximity navigation. The reduced-gravity conditions will be achieved during a campaign of parabolic flights thanks to the participation to the European Space Agency “Fly Your Thesis!” programme 2022

Flexible, digital enhanced reading device

A flexible, digital enhanced reading device (P) comprises at least one label containing encoded information, a spatially structured element placed over the label itself, defined by a material indicating predetermined temperature level and exposure time range, and comprising a material with morphological and/or structural and/or chemical and/or physical state changing properties detectable following a predetermined heat absorption; the mentioned spatially structural element is adapted to at least partially cover determined zones of said label with dimensions between 0.01% and 100% of the surface of the label itself, and comprises molecular materials and/or polymer materials and/or liquid crystals and/or mixtures of said materials in any proportion

Gemcitabine and liposomal doxorubicin in biliary and hepatic carcinoma (HCC) chemotherapy: preliminary results and review of the literature.

Abstract: Background: Advanced biliary tract cancers have a poor prognosis. Gemcitabine (G) as a single agent or in combination represents an active treatment option. Systemic chemotherapy in hepatocellular carcinoma represents a palliative treatment. Gemcitabine in combination with Liposomal Doxorubicin (LD) may represent an active treatment option. Patients and methods: Clinical trials for biliary and hepatic carcinoma have been reviewed. Results: We obtained RC (1 pt), RP (4 pts), SD (8 pts) and seven pts had PD (RR 25% and SD 40%). Our chemotherapy regimen was Gemcitabine 1000 mg/m(2) d 1 and 8, Liposomal Doxorubicin 30 mg d 1, q 28. Patients were 21 (17 M), aged 44 to 78 (median 63 yrs). Only in 8 pts we observed G 3-4 haematological toxicity, thrombocytopenia and neutropenia (7 G3, 1 G4)

Low energy radioactivity BG model in Super-Kamiokande detector from SK-IV data

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Follow-up of GWTC-2 gravitational wave events with neutrinos from the Super-Kamiokande detector

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Combined Pre-Supernova Alert System with Kamland and Super-Kamiokande

International audiencePreceding a core-collapse supernova, various processes produce an increasing amount of neutrinos of all flavors characterized by mounting energies from the interior of massive stars. Among them, the electron antineutrinos are potentially detectable by terrestrial neutrino experiments such as KamLAND and Super-Kamiokande via inverse beta decay interactions. Once these pre-supernova neutrinos are observed, an early warning of the upcoming core-collapse supernova can be provided. In light of this, KamLAND and Super-Kamiokande have been monitoring pre-supernova neutrinos since 2015 and 2021, respectively. Recently, we performed a joint study between KamLAND and Super-Kamiokande on pre-supernova neutrino detection. A pre-supernova alert system combining the KamLAND detector and the Super-Kamiokande detector is developed and put into operation, which can provide a supernova alert to the astrophysics community. Fully leveraging the complementary properties of these two detectors, the combined alert is expected to resolve a pre-supernova neutrino signal from a 15 M$_{\odot}$ star within 510 pc of the Earth, at a significance level corresponding to a false alarm rate of no more than 1 per century. For a Betelgeuse-like model with optimistic parameters, it can provide early warnings up to 12 hours in advance