7 research outputs found
Additional file 1: of Fluid loading in abdominal surgery - saline versus hydroxyethyl starch (FLASH Trial): study protocol for a randomized controlled trial
Acute kidney injury (AKI) risk index. (PDF 50Â kb
Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy - Fig 3
<p><b>Representative western blot and densitometric data reflecting protein expressions of β1-adrenoceptor (Panel A) and β3-adrenoceptor (Panel B) in left ventricles homogenates of healthy or diabetic rats, treated or not by atorvastatin (50 mg kg-1.day-1) during 15 days.</b> Western blot experiments were normalized using proteins using Ponceau S solution. Data are means ± SD (n = 4 to 9). *: <i>p</i><0.05 versus healthy untreated rats; †: <i>p</i><0.05 diabetic statin versus diabetic untreated rats.</p
General characteristics of healthy and diabetic treated (<i>atorvastatin</i>, 50 mg. kg<sup>-1</sup>.day<sup>-1</sup>) and control rats.
<p>General characteristics of healthy and diabetic treated (<i>atorvastatin</i>, 50 mg. kg<sup>-1</sup>.day<sup>-1</sup>) and control rats.</p
Active force (% of baseline value) variation of left ventricle papillary muscle exposed to isoproterenol in diabetic rats pretreated with statin (atorvastatin, 50 mg kg-1 day-1) during 15 days (8 rats per group) with or without L-NAME administration.
<p>Control refers to diabetic rats not receiving statin. AF/s = active force normalized per cross-sectional area during isometric contraction. Data are expressed as mean ± SD. NS: non-significant.</p
Effects of atorvastatin on the transcriptome of left ventricles of healthy or diabetic rats.
<p>Panel A-B Heat Map of RNA expression profiles in diabetic versus healthy left ventricles (Panel A) or in statin diabetic versus untreated diabetic left ventricles (Panel B); Color scale indicate relative expression ratio for each gene in diabetic versus healthy left ventricle (Panel A) or in statin versus untreated diabetic left ventricle. Panel C-D Volcano Plot for the modification of genes expression by diabetes in heart ventricle (Panel C) and by atorvastatin in diabetic left ventricle (Panel D). The vertical axis represents the <i>p</i> value (-log<sup>10</sup> <i>p</i> value) and the horizontal axis range the fold change (log<sup>2</sup> ratio) between diabetic and healthy left ventricles (Panel C) or statin diabetic versus untreated diabetic left ventricles (Panel D) (by t-test). Genes in the area delimited in red have a fold change greater than 1.5 with a <i>p</i> value < 0.05. Genes in the area delimited in green have a fold change greater than -1.5 (ratio <0.67) with a <i>p</i> value < 0.05. Panel E Venn diagram representing the differently expressed genes in diabetic versus healthy left ventricles in blue and in statin diabetic versus untreated diabetic left ventricles in red (<i>p</i><0.05). D is for down-regulation in diabetic versus healthy left ventricles, U for up-regulation. The overlapping part represents the genes modified by diabetes as well as statin, with up- or down-regulation for each comparison.</p
Representative Western Blot and densitometric data reflecting protein expressions of multidrug resistance protein 4 (MRP4) in left ventricles homogenates of healthy or diabetic rats, treated or not by atorvastatin (50 mg kg-1.day-1) during 15 days.
<p>Western blot experiments were normalized using GAPDH (37kDa). Data are means ± SD (n = 6). *: <i>p</i><0.05 versus healthy untreated rats; †: <i>p</i><0.05 diabetic statin versus diabetic untreated rats.</p