16 research outputs found
Evaluation of an Automated Analysis Tool for Prostate Cancer Prediction Using Multiparametric Magnetic Resonance Imaging
Objective To evaluate the diagnostic performance of an automated analysis tool for the assessment of prostate cancer based on multiparametric magnetic resonance imaging (mpMRI) of the prostate. Methods A fully automated analysis tool was used for a retrospective analysis of mpMRI sets (T2-weighted, T1-weighted dynamic contrast-enhanced, and diffusion-weighted sequences). The software provided a malignancy prediction value for each image pixel, defined as Malignancy Attention Index (MAI) that can be depicted as a colour map overlay on the original images. The malignancy maps were compared to histopathology derived from a combination of MRI-targeted and systematic transperineal MRI/TRUS-fusion biopsies. Results In total, mpMRI data of 45 patients were evaluated. With a sensitivity of 85.7% (with 95% CI of 65.4-95.0), a specificity of 87.5%(with 95% CI of 69.0-95.7) and a diagnostic accuracy of 86.7% (with 95% CI of 73.8-93.8) for detection of prostate cancer, the automated analysis results corresponded well with the reported diagnostic accuracies by human readers based on the PI-RADS system in the current literature. Conclusion The study revealed comparable diagnostic accuracies for the detection of prostate cancer of a user-independent MAI-based automated analysis tool and PI-RADS-scoring-based human reader analysis of mpMRI. Thus, the analysis tool could serve as a detection support system for less experienced readers. The results of the study also suggest the potential of MAI-based analysis for advanced lesion assessments, such as cancer extent and staging prediction
Examples of MAI profiles.
<p>Confirmed Gleason score 7a (3+4, left) and Gleason score 8 (4+4, right) lesions.</p
Example of a MAI map on a T2W image overlay.
<p>Example of a MAI map on a T2W image overlay.</p
Sensitivity, specificity and Youden index of MAI-based prostate cancer detection at different mean MAI threshold values.
<p>Sensitivity, specificity and Youden index of MAI-based prostate cancer detection at different mean MAI threshold values.</p
Parameter settings of deployed multiparametric MRI sequences.
<p>Parameter settings of deployed multiparametric MRI sequences.</p
Comparison of computed MAI diagnostic accuracy with that of human readers based on PI-RADS scoring.
<p>Comparison of computed MAI diagnostic accuracy with that of human readers based on PI-RADS scoring.</p