Additional file 1: of Human osteochondritis dissecans fragment-derived chondrocyte characteristics ex vivo, after monolayer expansion-induced de-differentiation, and after re-differentiation in alginate bead culture

mRNA expression values for collagen types I, II, and X (Col I, Col II, and Col X, respectively) and aggrecan as well as cell viability. (DOC 40 kb

Prognostic relevance of elevated pulmonary arterial pressure assessed non-invasively: Analysis in a large patient cohort with invasive measurements in near temporal proximity - Fig 4

<p><b>Outcome differentiated by PAP for subgroup of patients:</b> left ventricular cardiomyopathy (CMP):A,B; valvular heart disease: C,D; ischemic heart disease (IHD): E,F and rare cardiac diseases: G;H. Invasive measurements by RHC (A,C,E,G) are compared to non-invasively assessment by DE (B,D,F,G). <b>Abbreviations:</b> m/sPAP mean/systolic pulmonary arterial pressure, HR hazard ratio, 95%CI 95% confidence interval, ns not significant.</p

Multivariate analysis for independent predictive parameters.

<p>Multivariate analysis for independent predictive parameters.</p

Univariate survival analysis by Cox proportional regression.

<p>Univariate survival analysis by Cox proportional regression.</p

Incremental predictive information for survival of multimodal clinical settings based on complete-case data (n = 395).

<p><b>Abbreviations:</b> Clin: clinical assessment (age, sex, NYHA functional class), Clin+Echo: clinical assessment and transthoracic (Doppler) echocardiography (LV-EF, RV dysfunction, sPAP, RAP), Clin+Sero: clinical assessment and cardiac serological parameters (NT-proBNP, cTnT); Clin+Sero+Echo: clinical assessment, cardiac serological parameters and transthoracic echocardiography combined; Clin+Sero+Echo+RHC: Non-invasive diagnostics and RHC (CI, mPAP, RAP) combined; Clin+RHC: clinical assessment and RHC (CI, mPAP, RAP) combined. <b>**</b>p<0.001. NYHA New York Heart Association, LV-EF left ventricular ejection fraction, sPAP systolic pulmonary arterial pressure, RAP right atrial pressure, NT-proBNP N-terminal pro brain natriuretic peptide, cTnT cardiac troponin T, CI cardiac index, mPAP mean pulmonary arterial pressure, RHC right heart catheterization.</p

Survival of patients with or without PH as suggested by Doppler echocardiography visualized by Kaplan-Meier curves.

<p><b>Abbreviations:</b> PH pulmonary hypertension, sPAP systolic pulmonary arterial pressure, HR hazard ratio, 95%CI 95% confidence interval.</p

Hemodynamic characteristics of the study population.

<p>Hemodynamic characteristics of the study population.</p

Study protocol.

<p>Flow chart with inclusion criteria from catheter and echocardiography databases, identification of individual patients, and exclusion due to loss of clinical follow-up. <b>Abbreviation:</b> RHC right heart catheterization.</p