A Luminous Companion to SGR 1806-20

We have obtained infrared spectra of the star suggested to be the counterpart of the soft gamma-ray repeater (SGR) 1806-20. We found strong emission lines similar to those seen in the spectra of the rare Luminous Blue Variables and B[e] stars. A He I absorption line is also seen, from which we infer a spectral type O9--B2. This classification, in combination with the minimum distance of \simgt6 kpc inferred from its extinction, makes the star one of the most luminous in the Galaxy. We infer that it is a companion to SGR 1806-20, and suggest that the presence of a companion is somehow related to the SGR phenomenon.Comment: 5 pages, AASTEX text+table and 2 PostScript figures (needs LaTeX style files aaspptwo.sty, epsf.sty and rotate.sty). In case of problems, contact [email protected]. Postscript file of complete article available on request. (Replaced because first version had one wrong reference in it

Multiprotein DNA looping

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.Comment: 11 pages, 4 figure

The 2013 February 17 sunquake in the context of the active region's magnetic field configuration

© 2017. The American Astronomical Society. All rights reserved. Sunquakes are created by the hydrodynamic response of the lower atmosphere to a sudden deposition of energy and momentum. In this study, we investigate a sunquake that occurred in NOAA active region 11675 on 2013 February 17. Observations of the corona, chromosphere, and photosphere are brought together for the first time with a nonlinear force-free model of the active region's magnetic field in order to probe the magnetic environment in which the sunquake was initiated. We find that the sunquake was associated with the destabilization of a flux rope and an associated M-class GOES flare. Active region 11675 was in its emergence phase at the time of the sunquake and photospheric motions caused by the emergence heavily modified the flux rope and its associated quasi-separatrix layers, eventually triggering the flux rope's instability. The flux rope was surrounded by an extended envelope of field lines rooted in a small area at the approximate position of the sunquake. We argue that the configuration of the envelope, by interacting with the expanding flux rope, created a “magnetic lens” that may have focussed energy on one particular location of the photosphere, creating the necessary conditions for the initiation of the sunquake

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen

The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus. In rare cases, babies of mothers with MG, or even of asymptomatic mothers, develop a severe developmental condition, arthrogryposis multiplex congenita, caused by antibodies that inhibit the ion channel function of the fetal AChR while not affecting the adult AChR. Here we show that these fetal AChR inhibitory antibodies are significantly more common in females sampled after pregnancy than in those who present before pregnancy, suggesting that they may be induced by the fetus. Moreover, we were able to clone high-affinity combinatorial Fab antibodies from thymic cells of two mothers with MG who had babies with arthrogryposis multiplex congenita. These Fabs were highly specific for fetal AChR and did not bind the main immunogenic region that is common to fetal and adult AChR. The Fabs show strong biases to VH3 heavy chains and to a single Vk1 light chain in one mother. Nevertheless, they each show extensive intraclonal diversification from a highly mutated consensus sequence, consistent with antigen-driven selection in successive steps. Collectively, our results suggest that, in some cases of MG, initial immunization against fetal AChR is followed by diversification and expansion of B cells in the thymus; maternal autoimmunity will result if the immune response spreads to the main immunogenic region and other epitopes common to fetal and adult AChR

Controlling Link Congestion on Complex Network

We studied the impact of bandwidth utilization factor on converged network of Zain Contact Centre which is a complex network environment in Nigeria. Some congestion control techniques were reviewed. Experiments were carried out on the real network, a legacy network and an integrated converged network considering the same number of users. The corresponding packets were compared. As a result, higher throughput and minimal packet loss were achieved at lower bandwidth utilization and better than what was obtained at higher utilization using the same parameters

Diffraction-Limited Imaging and Photometry of NGC 1068

The nearby Seyfert 2 Galaxy NGC 1068 was observed with speckle imaging techniques in the near-infrared H-band (1.6 microns) at the Hale 200-inch Telescope and K-band (2.2 microns) at the 10 m Keck I Telescope. Images with diffraction limited or near-diffraction limited resolutions of 0.''05 - 0.''1 were obtained and used to search for structure in the nuclear region. Images of the nucleus of NGC 1068 reveal an extended region of emission which accounts for nearly 50% of the nuclear flux at K-band. This region extends 10 pc on either side of an unresolved point source nucleus which is at most, 0.''02 or 1.4 pc in size. Both the point source and the newly imaged extended emission are very red, with identical H-K colors corresponding to a color temperature of 800 K. While the point source is of a size to be consistent with grains in thermal equilibrium with the nuclear source, the extended emission is not. It must consist either of nuclear emission which has been reflected off an extended dusty disk or of small grains raised to transiently high temperatures by reflected UV photons.Comment: accepted to AJ, AAS LaTeX and epsfig, 22 pages incl. 5 ps figure