402 research outputs found
Non-detection of previously reported transits of HD 97658b with MOST photometry
The radial velocity-discovered exoplanet HD 97658b was recently announced to
transit, with a derived planetary radius of 2.93 \pm 0.28 R_{Earth}. As a
transiting super-Earth orbiting a bright star, this planet would make an
attractive candidate for additional observations, including studies of its
atmospheric properties. We present and analyze follow-up photometric
observations of the HD 97658 system acquired with the MOST space telescope. Our
results show no transit with the depth and ephemeris reported in the
announcement paper. For the same ephemeris, we rule out transits for a planet
with radius larger than 2.09 R_{Earth}, corresponding to the reported 3\sigma
lower limit. We also report new radial velocity measurements which continue to
support the existence of an exoplanet with a period of 9.5 days, and obtain
improved orbital parameters.Comment: 16 pages, 4 figures; 1 Table; accepted for publication in ApJL,
includes changes made in response to the referee repor
Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ level. The aim of this study was therefore to examine whether there was a correlation between resistance of the intrarenal arteries of the kidney and compliance of the left ventricle, as estimated by measurements of diastolic function, in subjects with type 2 diabetes.</p> <p>Methods</p> <p>We studied 167 unselected clinic patients with type 2 diabetes with a kidney duplex scan to estimate intrarenal vascular resistance, i.e. the resistance index (RI = peak systolic velocity-minimum diastolic velocity/peak systolic velocity) and a transthoracic echocardiogram (TTE) employing tissue doppler studies to document diastolic and systolic ventricular function.</p> <p>Results</p> <p>Renal RI was significantly higher in subjects with diastolic dysfunction (0.72 ± 0.05) when compared with those who had a normal TTE examination (0.66 ± 0.06, p < 0.01). Renal RI values were correlated with markers of diastolic dysfunction including the E/Vp ratio (r = 0.41, p < 0.001), left atrial area (r = 0.36, p < 0.001), the E/A ratio (r = 0.36, p < 0.001) and the E/E' ratio (r = 0.31, p < 0.001). These associations were independent of systolic function, hypertension, the presence and severity of chronic kidney disease, the use of renin-angiotensin inhibitors and other potentially confounding variables.</p> <p>Conclusion</p> <p>Increasing vascular resistance of the intrarenal arteries was associated with markers of diastolic dysfunction in subjects with type 2 diabetes. These findings are consistent with the hypothesis that vascular and cardiac stiffening in diabetes are manifestations of common pathophysiological mechanisms.</p
Momentum flow in black-hole binaries: II. Numerical simulations of equal-mass, head-on mergers with antiparallel spins
Research on extracting science from binary-black-hole (BBH) simulations has
often adopted a "scattering matrix" perspective: given the binary's initial
parameters, what are the final hole's parameters and the emitted gravitational
waveform? In contrast, we are using BBH simulations to explore the nonlinear
dynamics of curved spacetime. Focusing on the head-on plunge, merger, and
ringdown of a BBH with transverse, antiparallel spins, we explore numerically
the momentum flow between the holes and the surrounding spacetime. We use the
Landau-Lifshitz field-theory-in-flat-spacetime formulation of general
relativity to define and compute the density of field energy and field momentum
outside horizons and the energy and momentum contained within horizons, and we
define the effective velocity of each apparent and event horizon as the ratio
of its enclosed momentum to its enclosed mass-energy. We find surprisingly good
agreement between the horizons' effective and coordinate velocities. To
investigate the gauge dependence of our results, we compare pseudospectral and
moving-puncture evolutions of physically similar initial data; although
spectral and puncture simulations use different gauge conditions, we find
remarkably good agreement for our results in these two cases. We also compare
our simulations with the post-Newtonian trajectories and near-field
energy-momentum. [Abstract abbreviated; full abstract also mentions additional
results.]Comment: Submitted to Phys. Rev.
TADPOL: A 1.3 mm Survey of Dust Polarization in Star-forming Cores and Regions
We present {\lambda}1.3 mm CARMA observations of dust polarization toward 30
star-forming cores and 8 star-forming regions from the TADPOL survey. We show
maps of all sources, and compare the ~2.5" resolution TADPOL maps with ~20"
resolution polarization maps from single-dish submillimeter telescopes. Here we
do not attempt to interpret the detailed B-field morphology of each object.
Rather, we use average B-field orientations to derive conclusions in a
statistical sense from the ensemble of sources, bearing in mind that these
average orientations can be quite uncertain. We discuss three main findings:
(1) A subset of the sources have consistent magnetic field (B-field)
orientations between large (~20") and small (~2.5") scales. Those same sources
also tend to have higher fractional polarizations than the sources with
inconsistent large-to-small-scale fields. We interpret this to mean that in at
least some cases B-fields play a role in regulating the infall of material all
the way down to the ~1000 AU scales of protostellar envelopes. (2) Outflows
appear to be randomly aligned with B-fields; although, in sources with low
polarization fractions there is a hint that outflows are preferentially
perpendicular to small-scale B-fields, which suggests that in these sources the
fields have been wrapped up by envelope rotation. (3) Finally, even at ~2.5"
resolution we see the so-called "polarization hole" effect, where the
fractional polarization drops significantly near the total intensity peak. All
data are publicly available in the electronic edition of this article.Comment: 53 pages, 37 figures -- main body (13 pp., 3 figures), source maps
(32 pp., 34 figures), source descriptions (8 pp.). Accepted by the
Astrophysical Journal Supplemen
Effect of a self-determination theory-based communication skills training program on physiotherapists' psychological support for their patients with chronic low back pain: a randomized controlled trial
Objective: To examine the effects of communication skills training on physiotherapists' supportive behavior during clinical practice. Design: Randomized trial. Setting: Hospital outpatient physiotherapy clinics. Participants: Physiotherapists (N=24) and patients (N=24) with chronic low back pain. Interventions: Two hospital clinics were randomly assigned to the intervention arm. Physiotherapists (n=12) received 8 hours of communication skills training focused on supporting patients' psychological needs. Physiotherapists (n=12) from 2 other hospital clinics formed a waitlist control arm. Main Outcome Measures: Verbal communication between each physiotherapist and a patient was recorded on an audiotape, and independent, blinded raters used the Health Care Climate Questionnaire to assess physiotherapists' needs-supportive behavior (primary outcome). Results: Independent raters' Health Care Climate Questionnaire scores favored the intervention arm (Cohen's d=2.27; P<.01). Conclusions: Compared with controls, independent ratings demonstrated that physiotherapists who completed the Communication style and exercise compliance in physiotherapy training were found to provide greater support for patients' needs in a single assessed session. Long-term maintenance of this needs-supportive behavior should be examined
Viral Hepatitis and Rapid Diagnostic Test Based Screening for HBsAg in HIV-infected Patients in Rural Tanzania.
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Co-infection with hepatitis B virus (HBV) is highly prevalent in people living with HIV in Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg) before initiation of combination antiretroviral therapy (cART) is recommended. However, it is not part of diagnostic routines in HIV programs in many resource-limited countries although patients could benefit from optimized antiretroviral therapy covering both infections. Screening could be facilitated by rapid diagnostic tests for HBsAg. Operating experience with these point of care devices in HIV-positive patients in Sub-Saharan Africa is largely lacking. We determined the prevalence of HBV and Hepatitis C virus (HCV) infection as well as the diagnostic accuracy of the rapid test device Determine HBsAg in an HIV cohort in rural Tanzania. Prospectively collected blood samples from adult, HIV-1 positive and antiretroviral treatment-naïve patients in the Kilombero and Ulanga antiretroviral cohort (KIULARCO) in rural Tanzania were analyzed at the point of care with Determine HBsAg, a reference HBsAg EIA and an anti-HCV EIA. Samples of 272 patients were included. Median age was 38 years (interquartile range [IQR] 32-47), 169/272 (63%) subjects were females and median CD4+ count was 250 cells/µL (IQR 97-439). HBsAg was detected in 25/272 (9.2%, 95% confidence interval [CI] 6.2-13.0%) subjects. Of these, 7/25 (28%) were positive for HBeAg. Sensitivity of Determine HBsAg was rated at 96% (95% CI 82.8-99.6%) and specificity at 100% (95% CI, 98.9-100%). Antibodies to HCV (anti-HCV) were found in 10/272 (3.7%, 95% CI 2.0-6.4%) of patients. This study reports a high prevalence of HBV in HIV-positive patients in a rural Tanzanian setting. The rapid diagnostic test Determine HBsAg is an accurate assay for screening for HBsAg in HIV-1 infected patients at the point of care and may further help to guide cART in Sub-Saharan Africa
Heritage Quay: What Will You Discover? Transforming the Archives of the University of Huddersfield, Yorkshire, UK
The Heritage Quay project is changing how archive services at the University of Huddersfield are delivered. This article examines how the Staff/Space/Collections dependency model and Customer Service Excellence framework have been used, and what lessons can be drawn for other archives
The promise and the reality: a mental health workforce perspective on technology-enhanced youth mental health service delivery
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Digital technologies show promise for reversing poor engagement of youth (16–24 years) with mental health services. In particular, mobile and internet based applications with communication capabilities can augment face-to-face mental health service provision. The literature in this field, however, fails to adequately capture the perspectives of the youth mental health workforce regarding utility and acceptability of technology for this purpose.
Methods: This paper describes results of in-depth qualitative data drawn from various stakeholders involved in provision of youth mental health services in one Australian rural region. Data were obtained using focus groups and semi-structured interviews with regional youth mental health clinicians, youth workers and support/management staff (n = 4 focus groups; n = 8 interviews) and analysed via inductive thematic analysis.
Results: Results question the acceptability of technology to engage clients within youth mental health services. Six main themes were identified: young people in a digital age, personal connection, power and vulnerability, professional identity, individual factors and organisational legitimacy.
Conclusions:These findings deepen the understanding of risks and challenges faced when adopting new technologies in mental healthcare. Recommendations for technology design and implementation in mental health services are made
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.We acknowledge the following
funding agencies: Leukaemia Foundation of Australia, Arrow Bone Marrow Transplant
Foundation, National Health and Medical Research Council Australia, Cancer Council
Victoria, Victorian Cancer Agency, Australian Cancer Research Foundation, Peter
MacCallum Cancer Centre Foundation, National Institutes of Health
Recreating the OSIRIS-REx Slingshot Manoeuvre from a Network of Ground-Based Sensors
Optical tracking systems typically trade-off between astrometric precision
and field-of-view. In this work, we showcase a networked approach to optical
tracking using very wide field-of-view imagers that have relatively low
astrometric precision on the scheduled OSIRIS-REx slingshot manoeuvre around
Earth on September 22nd, 2017. As part of a trajectory designed to get
OSIRIS-REx to NEO 101955 Bennu, this flyby event was viewed from 13 remote
sensors spread across Australia and New Zealand to promote triangulatable
observations. Each observatory in this portable network was constructed to be
as lightweight and portable as possible, with hardware based off the successful
design of the Desert Fireball Network.
Over a 4 hour collection window, we gathered 15,439 images of the night sky
in the predicted direction of the OSIRIS-REx spacecraft. Using a specially
developed streak detection and orbit determination data pipeline, we detected
2,090 line-of-sight observations. Our fitted orbit was determined to be within
about 10~km of orbital telemetry along the observed 109,262~km length of
OSIRIS-REx trajectory, and thus demonstrating the impressive capability of a
networked approach to SSA
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