American Political Parties

American Political Parties is a core textbook on political parties in the United States that places the US party system into a framework designed around the disagreements between Alexander Hamilton and Thomas Jefferson. White and Kerbel argue that the two-party system in the United States began with a common agreement on the key values of freedom, individual rights, and equality of opportunity but that Hamilton and Jefferson disagreed—often vehemently—over how to translate these ideals into an acceptable form of governance. This text develops a unique historical perspective of US party development using the disagreements between Alexander Hamilton and Thomas Jefferson as a framework for analysis. While Hamilton wanted to marry freedom to a strong, active federal government with an energetic president who would act on behalf of all citizens, Jefferson believed that freedom should be allied to local civic virtue, with governmental responsibilities placed primarily at the local level. Today, Hamiltonian nationalism finds its home in the Democratic Party, while Republicans have espoused Jeffersonian localism since 1964. Using this historical framework, American Political Parties examines a range of topics including marketing and social media, campaign finance, reforms in the presidential nominating process, political demography, and third parties. In this new edition (previously published as Party On!), the authors describe four possible futures in the wake of the 2020 election and why Americans believed it was “the most important” election in their lifetimes. The unique history of US political parties as set forth by the disagreements between Alexander Hamilton and Thomas Jefferson is at an inflection point. Republicans have become an insurgent party fully under the control of Donald Trump while Democrats have an opportunity to create a new majority coalition. This juncture poses unique challenges to our democracy and constitutional framework, and the book describes four possible outcomes, postulating where American political parties are headed in this decade. This book is published as part of the Sustainable History Monograph Pilot, with the generous support of the Andrew W. Mellon Foundation

Lenalidomide and metronomic melphalan for CMML and higher risk MDS: A phase 2 clinical study with biomarkers of angiogenesis

AbstractMetronomic, low dose chemotherapy may have anti-angiogenic effects and augment the effects of lenalidomide in MDS and CMML. We evaluated the clinical efficacy, tolerability and anti-angiogenic effects of melphalan 2mg and lenalidomide 10mg for 21 days/28 in CMML (n=12) and higher risk MDS (n=8) patients in a prospective phase II study. The primary endpoint was overall response and secondary endpoints included survival, progression-free survival, toxicity and biomarkers of angiogenesis. The median age was 73 years, 55% were pretreated and transfusion dependent. The overall response rate was 3(15%) of 19 evaluable patients but 25% in CMML and 33% in pCMML. Dose reductions and/or delays were common due to myelosuppression. Transient spikes in circulating endothelial cells that declined below baseline were seen in responders and patients with CMML, suggesting anti-angiogenic activity. In conclusion, lenalidomide and metronomic low dose melphalan demonstrate signals of clinical and possible anti-angiogenic activity in patients with pCMML that require future validation. This trial was registered at clinicaltrial.gov under # NCT00744536

Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

While there is significant interest in combining anti-angiogenesis therapy with conventional anti-cancer treatment, clinical trials have as of yet yielded limited therapeutic gain, mainly because mechanisms of anti-angiogenic therapy remain to a large extent unknown. Currently, anti-angiogenic tumor therapy is conceptualized to either "normalize" dysfunctional tumor vasculature, or to prevent recruitment of circulating endothelial precursors into the tumor. An alternative biology, restricted to delivery of anti-angiogenics immediately prior to single dose radiotherapy (radiosurgery), is provided in the present study.Genetic data indicate an acute wave of ceramide-mediated endothelial apoptosis, initiated by acid sphingomyelinase (ASMase), regulates tumor stem cell response to single dose radiotherapy, obligatory for tumor cure. Here we show VEGF prevented radiation-induced ASMase activation in cultured endothelium, occurring within minutes after radiation exposure, consequently repressing apoptosis, an event reversible with exogenous C(16)-ceramide. Anti-VEGFR2 acts conversely, enhancing ceramide generation and apoptosis. In vivo, MCA/129 fibrosarcoma tumors were implanted in asmase(+/+) mice or asmase(-/-) littermates and irradiated in the presence or absence of anti-VEGFR2 DC101 or anti-VEGF G6-31 antibodies. These anti-angiogenic agents, only if delivered immediately prior to single dose radiotherapy, de-repressed radiation-induced ASMase activation, synergistically increasing the endothelial apoptotic component of tumor response and tumor cure. Anti-angiogenic radiosensitization was abrogated in tumors implanted in asmase(-/-) mice that provide apoptosis-resistant vasculature, or in wild-type littermates pre-treated with anti-ceramide antibody, indicating that ceramide is necessary for this effect.These studies show that angiogenic factors fail to suppress apoptosis if ceramide remains elevated while anti-angiogenic therapies fail without ceramide elevation, defining a ceramide rheostat that determines outcome of single dose radiotherapy. Understanding the temporal sequencing of anti-angiogenic drugs and radiation enables optimized radiosensitization and design of innovative radiosurgery clinical trials

Eye of the Beholder: Identifying Underlying Characteristics of Policy Success Across Presidential Administrations.

Presidential power is approached in a systematic fashion in order to (1) facilitate the study of power across administrations; (2) identify the elements of power under ordinary circumstances not involving comm and ; (3) connect the exercise of power with its ends; and (4) determine the relative importance of personal and institutional factors in the exercise of power. Perceptions of the President's utilization of fifteen resources were measured for four cases of policy success and four cases of policy failure during the Carter and Reagan administrations. Power was hypothesized to be a function of the response of policy actors to a specific array of resources, present during all instances of success despite idiosyncratic characteristics of the two administrations. The data support this contention for a variety of resources targeted by the President in dealings with Congress, and for a smaller number of resources directed to dealings with the executive branch and the public. These findings provide the basis for the development of a deductive model of presidential power in the domestic policy arena, centering on five domains of effective resource use: executive branch efficiency, executive branch-congressional relations, presidential-congressional relations, pressure on Congress, and access to the public. The personal model of presidential power is found to be overstated, based on the prominent role of institutionally-derived resources in all cases of policy success. The use of this approach for the study of power in foreign policy matters is considered, and implications for the exercise of power are discussed.Ph.D.Political scienceUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/161668/1/8801342.pd

American Political Parties: Why They Formed, How They Function, and Where They're Headed

John Kenneth White is professor of politics at the Catholic University of America in Washington, DC. He is the author of What Happened to the Republican Party? and Barack Obama’s America: How New Conceptions of Race, Family, and Religion Ended the Reagan Era. Matthew R. Kerbel is professor of political science at Villanova University in Villanova, Pennsylvania. He is the author of nine books, including Netroots and Next Generation Netroots, both about the emergence of internet politics and political engagement.This book is published as part of the Sustainable History Monograph Pilot. With the generous support of the Andrew W. Mellon Foundation, the Pilot uses cutting-edge publishing technology to produce open access digital editions of high-quality, peer-reviewed monographs from leading university presses. Free digital editions can be downloaded from: Books at JSTOR, EBSCO, Internet Archive, OAPEN, Project MUSE, ScienceOpen, and many other open repositories.American Political Parties is a core textbook on political parties in the United States that places the US party system into a framework designed around the disagreements between Alexander Hamilton and Thomas Jefferson. White and Kerbel argue that the two-party system in the United States began with a common agreement on the key values of freedom, individual rights, and equality of opportunity but that Hamilton and Jefferson disagreed—often vehemently—over how to translate these ideals into an acceptable form of governance. This text develops a unique historical perspective of US party development using the disagreements between Alexander Hamilton and Thomas Jefferson as a framework for analysis. While Hamilton wanted to marry freedom to a strong, active federal government with an energetic president who would act on behalf of all citizens, Jefferson believed that freedom should be allied to local civic virtue, with governmental responsibilities placed primarily at the local level. Today, Hamiltonian nationalism finds its home in the Democratic Party, while Republicans have espoused Jeffersonian localism since 1964. Using this historical framework, American Political Parties examines a range of topics including marketing and social media, campaign finance, reforms in the presidential nominating process, political demography, and third parties. In this new edition (previously published as Party On!), the authors describe four possible futures in the wake of the 2020 election and why Americans believed it was “the most important” election in their lifetimes. The unique history of US political parties as set forth by the disagreements between Alexander Hamilton and Thomas Jefferson is at an inflection point. Republicans have become an insurgent party fully under the control of Donald Trump while Democrats have an opportunity to create a new majority coalition. This juncture poses unique challenges to our democracy and constitutional framework, and the book describes four possible outcomes, postulating where American political parties are headed in this decade