Clinical characteristics of study population.

†<p>Mann Whitney test.</p>††<p>Chi-square test.</p

Results of the ROC curve analysis for all the studied markers.

<p>Results of the ROC curve analysis for all the studied markers.</p

Predictive accuracy of the combined models in predicting the presence of PCa at initial biopsy.

<p>°Compared with the base model - De Long method.</p

Association of patient and tumor characteristics with unfavorable prognosis: univariate and multivariate analysis.

<p>¹Mantel-Haenszel p-value for trend = <0.0001</p><p>*T test or non parametric two-sample Wilcoxon test for continuous variables, as appropriate; Chi-Square test or Fisher’s Exact Test for categorical variables, as appropriate</p><p>²One-unit increase OR</p><p>³Not entered in the multivariate model because it is a linear combination of other variables.</p><p>Note: significant ORs and p-values are in bold.</p><p>Association of patient and tumor characteristics with unfavorable prognosis: univariate and multivariate analysis.</p

Decision curve analysis of the effect of prediction models on the detection of a) upgrading, b) extra capsular extension, c) unfavorable prognosis, d) tumor volume and e) seminal vesicle invasion.

<p>Model with PIRADS score (red line) is plotted against treat none (violet line), treat all (green line) and model without PIRADS score (blue line).</p

Patient and tumor characteristics of the study population.

<p>^mean (± SD)</p><p>Patient and tumor characteristics of the study population.</p

Sensitivity (SE), specificity (SP), positive predicted values (PPV) and negative predicted values (NPV) with 95%(CI) for 1–2 vs. ≥ 3 PIRADS score.

<p>*Percentage</p><p>Sensitivity (SE), specificity (SP), positive predicted values (PPV) and negative predicted values (NPV) with 95%(CI) for 1–2 vs. ≥ 3 PIRADS score.</p

ROC Curves comparing models with and without inclusion of PIRADS score for a) Gleason score (GS) upgrading, b) extra capsular extension, c) unfavorable prognosis, d) tumor volume and e) seminal vesicle invasion.

<p>ROC Curves comparing models with and without inclusion of PIRADS score for a) Gleason score (GS) upgrading, b) extra capsular extension, c) unfavorable prognosis, d) tumor volume and e) seminal vesicle invasion.</p